Abstract
Purpose of Review
Image-guided percutaneous breast biopsy of both palpable and non-palpable findings has become standard of care. These minimally invasive breast procedures can avoid a surgical procedure for patients who have benign findings and can also guide pre-surgical management for malignant pathology. Establishing radiology-pathologic concordance is critical to guide appropriate management and is often performed between the radiologist and pathologist. However, the role of a multidisciplinary team and understanding the overall clinical context can better guide clinical care, particularly when imaging and pathologic findings may be uncertain.
Recent Findings
This article presents a series of difficult cases where multidisciplinary input is needed to help guide subspecialty decision-making.
Summary
A multidisciplinary team that has an understanding of what information is needed to guide subspecialty decision making and recommendations can improve patient management, particularly in uncertain radiology-pathology situations.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as:•• Of major importance
Prakash S, Venkataraman S, Slanetz PJ, Dialani V, Fein-Zachary V, Littlehale N, et al. Improving patient care by incorporation of multidisciplinary breast radiology-pathology correlation conference. Can Assoc Radiol J. 2016;67(2):122–9.
•• D’Orsi CJ SE, Mendelson EB, Morris EA et al. ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System. 5th ed. Reston, VA: American College of Radiology. 2013. This manual provides standardized breast imaging terminology and guidance for all imaging modalities and follow-up and outcomes monitoring. Although not recently published, it is the source for breast imaging reporting guidelines.
Rakha EA, Ellis IO. Diagnostic challenges in papillary lesions of the breast. Pathology. 2018;50(1):100–10.
Wen X, Cheng W. Nonmalignant breast papillary lesions at core-needle biopsy: a meta-analysis of underestimation and influencing factors. Ann Surg Oncol. 2013;20(1):94–101.
Jung SY, Kang HS, Kwon Y, Min SY, Kim EA, Ko KL, et al. Risk factors for malignancy in benign papillomas of the breast on core needle biopsy. World J Surg. 2010;34(2):261–5.
Nakhlis F, Ahmadiyeh N, Lester S, Raza S, Lotfi P, Golshan M. Papilloma on core biopsy: excision vs. observation. Ann Surg Oncol. 2015;22(5):1479–82.
Rizzo M, Linebarger J, Lowe MC, Pan L, Gabram SG, Vasquez L, et al. Management of papillary breast lesions diagnosed on core-needle biopsy: clinical pathologic and radiologic analysis of 276 cases with surgical follow-up. J Am Coll Surg. 2012;214(3):280–7.
Armes JE, Galbraith C, Gray J, Taylor K. The outcome of papillary lesions of the breast diagnosed by standard core needle biopsy within a Breast Screen Australia service. Pathology. 2017;49(3):267–70.
Shoker BS, Jarvis C, Sibson DR, Walker C, Sloane JP. Oestrogen receptor expression in the normal and pre-cancerous breast. J Pathol. 1999;188(3):237–44.
Costarelli L, Campagna D, Mauri M, Fortunato L. Intraductal proliferative lesions of the breast-terminology and biology matter: premalignant lesions or preinvasive cancer? Int J Surg Oncol. 2012;2012:501904.
Asirvatham JR, Falcone MM, Kleer CG. Atypical apocrine adenosis: diagnostic challenges and pitfalls. Arch Pathol Lab Med. 2016;140(10):1045–51.
Calhoun BC, Booth CN. Atypical apocrine adenosis diagnosed on breast core biopsy: implications for management. Hum Pathol. 2014;45(10):2130–5.
Carter DJ, Rosen PP. Atypical apocrine metaplasia in sclerosing lesions of the breast: a study of 51 patients. Mod Pathol. 1991;4(1):1–5.
Fuehrer N, Hartmann L, Degnim A, Allers T, Vierkant R, Frost M, et al. Atypical apocrine adenosis of the breast: long-term follow-up in 37 patients. Arch Pathol Lab Med. 2012;136(2):179–82.
Seidman JD, Ashton M, Lefkowitz M. Atypical apocrine adenosis of the breast: a clinicopathologic study of 37 patients with 8.7-year follow-up. Cancer. 1996;77(12):2529–37.
Jackman RJ, Marzoni FA, Rosenberg J. False-negative diagnoses at stereotactic vacuum-assisted needle breast biopsy: long-term follow-up of 1,280 lesions and review of the literature. Am J Roentgenol. 2009;192(2):341–51.
Liberman L, Benton CL, Dershaw DD, Abramson AF, LaTrenta LR, Morris EA. Learning curve for stereotactic breast biopsy: how many cases are enough? AJR Am J Roentgenol. 2001;176(3):721–7.
Boba M, Kołtun U, Bobek-Billewicz B, Chmielik E, Eksner B, Olejnik T. False-negative results of breast core needle biopsies - retrospective analysis of 988 biopsies. Pol J Radiol. 2011;76(1):25–9.
Lee CH, Philpotts LE, Horvath LJ, Tocino I. Follow-up of breast lesions diagnosed as benign with stereotactic core-needle biopsy: frequency of mammographic change and false-negative rate. Radiology. 1999;212(1):189–94.
Heller SL, Jaglan S, Babb JS, Melsaether A, Toth HB, Moy L. Frequency of discordant lesions and false-negative cancers at stereotactic vacuum-assisted biopsy. Acad Radiol. 2016;23(8):994–9.
Morgan C, Shah ZA, Hamilton R, Wang J, Spigel J, Deleon W, et al. The radial scar of the breast diagnosed at core needle biopsy. Proc (Bayl Univ Med Cent). 2012;25(1):3–5.
Cohen MA, Newell MS. Radial scars of the breast encountered at core biopsy: review of histologic, imaging, and management considerations. AJR Am J Roentgenol. 2017;209(5):1168–77.
Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol. 2010;34(6):896–900.
Conlon N, D’Arcy C, Kaplan JB, Bowser ZL, Cordero A, Brogi E, et al. Radial scar at image-guided needle biopsy: is excision necessary? Am J Surg Pathol. 2015;39(6):779–85.
Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, et al. The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions. Breast Cancer Res Treat. 2012;136(3):627–33.
Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, et al. Stratification of breast cancer risk in women with atypia: a Mayo cohort study. J Clin Oncol. 2007;25(19):2671–7.
Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K. Atypical hyperplasia of the breast — risk assessment and management options. N Engl J Med. 2014;372(1):78–89.
Choi AH, Blount S, Perez MN, de Paz Chavez CE, Rodriguez SA, Surrusco M, et al. Size of extranodal extension on sentinel lymph node dissection in the American College of Surgeons Oncology Group Z0011 Trial Era. JAMA Surg. 2015;150(12):1141–8.
•• Giuliano AE, Ballman KV, McCall L, Beitsch PD, Brennan MB, Kelemen PR, et al. Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial. JAMA. 2017;318(10):918–26. This paper described long-term outcome follow-up of women enrolled in the ACOSOG Z0011 trial which showed similar survival outcomes in women with T1 or T2 invasive primary cancer with non-palpable axillary lymphadanotphy treated with sentinal lymph node dissection alone versus axillary lymph node dissection.
Gooch J, King TA, Eaton A, Dengel L, Stempel M, Corben AD, et al. The extent of extracapsular extension may influence the need for axillary lymph node dissection in patients with T1–T2 breast cancer. Ann Surg Oncol. 2014;21(9):2897–903.
Katz A, Strom EA, Buchholz TA, Thames HD, Smith CD, Jhingran A, et al. Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. J Clin Oncol. 2000;18(15):2817–27.
Geng W, Zhang B, Li D, Liang X, Cao X. The effects of ECE on the benefits of PMRT for breast cancer patients with positive axillary nodes. J Radiat Res. 2013;54(4):712–8.
Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981–22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014;15(12):1303–10.
Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA. 2011;305(6):569–75.
Cardoso F, van’t Veer LJ, Bogaerts J, Slaets L, Viale G, Delaloge S, et al. 70-gene signature as an aid to treatment decisions in early-stage breast cancer. N Engl J Med. 2016;375(8):717–29.
National Cancer Institute. Tamoxifen citrate, letrozole, anastrozole, or exemestane with or without chemotherapy in treating patients with invasive RxPONDER breast cancer. Available from: https://www.clinicaltrials.gov/ct2/show/NCT01272037. ClinicalTrials.gov Identifier: NCT01272037. Accessed January 14, 2021.
NSABP Foundation Inc. Standard or comprehensive radiation therapy in treating patients with early-stage breast cancer previously treated with chemotherapy and surgery. Available from: https://clinicaltrials.gov/ct2/show/NCT01872975. ClinicalTrials.gov Identifier: NCT01872975. Accessed January 18, 2021.
von Minckwitz G, Huang CS, Mano MS, Loibl S, Mamounas EP, Untch M, et al. Trastuzumab emtansine for residual invasive HER2-positive breast cancer. N Engl J Med. 2019;380(7):617–28.
Symmans WF, Wei C, Gould R, Yu X, Zhang Y, Liu M, et al. Long-term prognostic risk after neoadjuvant chemotherapy associated with residual cancer burden and breast cancer subtype. J Clin Oncol. 2017;35(10):1049–60.
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This article is part of the Topical Collection on Best Practice Approaches Breast Radiology-Pathology Correlation and Management
Rights and permissions
About this article
Cite this article
Lam, D.L., Parker, E.U., Kim, J.N. et al. A Multidisciplinary Approach to Managing Uncertainty. Curr Breast Cancer Rep 13, 365–380 (2021). https://doi.org/10.1007/s12609-021-00437-9
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12609-021-00437-9