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Mammographic Density: Intersection of Advocacy, Science, and Clinical Practice

  • Risk and Prevention (ME Wood, Section Editor)
  • Published:
Current Breast Cancer Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Here we aim to review the association between mammographic density, collagen structure, and breast cancer risk.

Recent Findings

While mammographic density is a strong predictor of breast cancer risk in populations, studies by Boyd show that mammographic density does not predict breast cancer risk in individuals. Mammographic density is affected by age, parity, menopausal status, race/ethnicity, and body mass index (BMI). New studies normalize mammographic density to BMI and this may provide a more accurate way to compare mammographic density in women of diverse race and ethnicity. Preclinical and tissue-based studies have investigated the role collagen composition and structure in predicting breast cancer risk. There is emerging evidence that collagen structure may activate signaling pathways associated with aggressive breast cancer biology.

Summary

Measurement of film mammographic density does not adequately capture the complex signaling that occurs in women with at-risk collagen. New ways to measure at-risk collagen potentially can provide a more accurate view of risk.

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Funding

This work was financially supported by the National Institutes of Health/National Cancer Institute (NIH/NCI) grants R01CA155664, R01CA158668, R01CA170851, R01CA192914, and U01CA189283 (all to VLS) and P30CA033572.

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Authors and Affiliations

  1. Chicago Cancer Center, University of Illinois, Chicago, IL, USA

    Katherine Tossas-Milligan & Robert Winn

  2. Department of Population Sciences, City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd., Duarte, CA, 91010, USA

    Sundus Shalabi, Veronica Jones, Christopher Sistrunk, Joseph Geradts, Eric C. Dietze, Lisa D. Yee & Victoria L. Seewaldt

  3. West Bank, Al Quds University, Jerusalem, Israel

    Sundus Shalabi

  4. University of Wisconsin, Madison, Madison, WI, USA

    Patricia J. Keely, Matthew W. Conklin & Kevin W. Eliceiri

  5. University of Tennessee Health Science Center, Memphis, TN, USA

    Gustavo A. Miranda-Carboni

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Katherine Tossas-Milligan and Sundus Shalabi are co-first authors.

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Tossas-Milligan, K., Shalabi, S., Jones, V. et al. Mammographic Density: Intersection of Advocacy, Science, and Clinical Practice. Curr Breast Cancer Rep 11, 100–110 (2019). https://doi.org/10.1007/s12609-019-00316-4

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