Current Breast Cancer Reports

, Volume 10, Issue 2, pp 110–121 | Cite as

Local-Regional Evaluation and Therapy: Maximizing Margin-Negative Breast Cancer Resection Rates on the First Try

  • Lacey Stelle
  • Jennifer Wellington
  • Wen Liang
  • Robert Buras
  • Lorraine Tafra
Local-Regional Evaluation and Therapy (DM Euhus, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Local-Regional Evaluation and Therapy


Purpose of the review

Numerous strategies and technologies have been historically used, with new ones being rapidly introduced, to maximize the chance of obtaining clear margins at the first lumpectomy. The goal of this review was to summarize the data on each, illustrate their strengths and weaknesses, and equip the surgeon to determine which best fits into their center or practice.

Recent Findings

There is no technology or device currently that always results in negative margins. Many of the studies reviewed (including frozen sections, shave margins, specimen radiography, intraoperative ultrasound, imprint cytology, and new devices) show excellent negative margin rates, but many of the comparison studies have conflicting results and reasons for this are discussed. Newer emerging technologies hold great promise but there is a tendency to overinflate positive results.


It is important for surgeons to review their own re-excision rates to determine the need for further technology and strategies. Most of the investigative technologies are still years away from widespread acceptance.


Breast cancer Local-regional evaluation Margins Technology Margin devices 



The authors thank Stephanie Parlacoski, BS, for clerical assistance.

Compliance With Ethical Standards

Conflict of Interest

The authors declare that they have no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Lacey Stelle
    • 1
  • Jennifer Wellington
    • 1
  • Wen Liang
    • 1
  • Robert Buras
    • 1
  • Lorraine Tafra
    • 1
  1. 1.Rebecca Fortney Breast Center, Anne Arundel Medical CenterAnnapolisUSA

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