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Association between Dietary Protein Intake and Cognitive Function in Adults Aged 60 Years and Older

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The journal of nutrition, health & aging

Abstract

Objectives

The aim of this study was to examine the association of dietary protein intake and protein sources with cognitive function in population aged 60 years and older.

Design

Cross-sectional study.

Setting

The National Health and Nutrition Examination Survey (NHANES) 2011–2014.

Participants

Non-institutionalized US adults aged 60 years and older.

Measurements

Cognitive functions were assessed by a series of cognitive tests. Dietary protein intake was assessed by two 24-hour dietary recall interviews. Linear regression analyses were used to assess the associations between quartiles of dietary protein intake and cognitive function.

Results

Protein intake was positively associated with cognitive function. In full-adjusted model, the significant association between dietary protein intake and Recall Test score was observed (quartile (Q) 2 versus Q1, β=0.24, 95%CI: 0.01 to 0.47); the association between protein intake and Animal Fluency test was significant (Q2 versus Q1, β=1.40, 95%CI: 0.51 to 2.29; Q4 versus Q1, β=1.42, 95%CI: 0.37 to 2.48); the positive associations with DSST score and Composite z-score were observed both in Q2 versus Q1 and Q3 versus Q1 of protein intake. Protein intake from total animal, total meat, eggs and legumes were associated with a better performance on certain cognitive tests. However, an adverse association between higher protein intake from milk and milk products and cognitive function was observed.

Conclusions

We found the positive associations of dietary protein intake and protein intake from total animal, total meat, eggs and legumes with cognitive function in adults aged 60 years and older, while higher milk and milk products were negatively associated with cognitive function.

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References

  1. Nations U Ageing http://www.un.org/en/sections/issues-depth/ageing/index.html Accessed 27 February

  2. Hebert LE, Weuve J, Scherr PA, et al. Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology 2013;80: 1778.

    Article  Google Scholar 

  3. Gaugler JE, Duval S, Anderson KA, et al. Predicting nursing home admission in the U.S: a meta-analysis. BMC geriatrics 2007;7: 13.

    Article  Google Scholar 

  4. Wimo A, Jonsson L, Bond J, et al. The worldwide economic impact of dementia 2010. Alzheimer’s & dementia: the journal of the Alzheimer’s Association 2013;9: 1–11.e3.

    Article  Google Scholar 

  5. Xu C, Sun J, Duan H, et al. Gene, environment and cognitive function: a Chinese twin ageing study. Age and ageing 2015;44: 452–7.

    Article  Google Scholar 

  6. Selhub J, Bagley LC, Miller J, et al. B vitamins, homocysteine, and neurocognitive function in the elderly. The American journal of clinical nutrition 2000;71: 614s–620s.

    Article  CAS  Google Scholar 

  7. Yaffe K, Fiocco AJ, Lindquist K, et al. Predictors of maintaining cognitive function in older adults: the Health ABC study. Neurology 2009;72: 2029–35.

    Article  CAS  Google Scholar 

  8. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial. Archives of neurology 2006;63: 1402–8.

    Article  Google Scholar 

  9. Psaltopoulou T, Kyrozis A, Stathopoulos P, et al. Diet, physical activity and cognitive impairment among elders: the EPIC-Greece cohort (European Prospective Investigation into Cancer and Nutrition). Public health nutrition 2008;11: 1054–62.

    Article  CAS  Google Scholar 

  10. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary intake of antioxidants and risk of Alzheimer disease. Jama 2002;287: 3223–9.

    Article  CAS  Google Scholar 

  11. Roberts RO, Geda YE, Cerhan JR, et al. Vegetables, unsaturated fats, moderate alcohol intake, and mild cognitive impairment. Dementia and geriatric cognitive disorders 2010;29: 413–23.

    Article  CAS  Google Scholar 

  12. LaRue A, Koehler KM, Wayne SJ, et al. Nutritional status and cognitive functioning in a normally aging sample: A 6-y reassessment. American Journal of Clinical Nutrition 1997;65: 20–29.

    Article  CAS  Google Scholar 

  13. Lee L, Kang SA, Lee HO, et al. Relationships between dietary intake and cognitive function level in Korean elderly people. Public Health 2001;115: 133–8.

    Article  CAS  Google Scholar 

  14. Nes M, Sem SW, Rousseau B, et al. Dietary intakes and nutritional status of old people with dementia living at home in Oslo. Eur J Clin Nutr 1988;42: 581–93.

    CAS  PubMed  Google Scholar 

  15. Roberts RO, Roberts LA, Geda YE, et al. Relative intake of macronutrients impacts risk of mild cognitive impairment or dementia. J Alzheimers Dis 2012;32: 329–39.

    Article  CAS  Google Scholar 

  16. van der Zwaluw NL, van de Rest O, Tieland M, et al. The impact of protein supplementation on cognitive performance in frail elderly. Eur J Nutr 2014;53: 803–12.

    Article  Google Scholar 

  17. Deschamps V, Astier X, Ferry M, et al. Nutritional status of healthy elderly persons living in Dordogne, France, and relation with mortality and cognitive or functional decline. Eur J Clin Nutr 2002;56: 305–12.

    Article  CAS  Google Scholar 

  18. Katsiardanis K, Diamantaras AA, Dessypris N, et al. Cognitive impairment and dietary habits among elders: the Velestino Study. J Med Food 2013;16: 343–50.

    Article  Google Scholar 

  19. Ortega RM, Requejo AM, Andres P, et al. Dietary intake and cognitive function in a group of elderly people. Am J Clin Nutr 1997;66: 803–9.

    Article  CAS  Google Scholar 

  20. Velho S, Marques-Vidal P, Baptista F, et al. Dietary intake adequacy and cognitive function in free-living active elderly: a cross-sectional and short-term prospective study. Clin Nutr 2008;27: 77–86.

    Article  Google Scholar 

  21. Vercambre MN, Boutron-Ruault MC, Ritchie K, et al. Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women. British Journal of Nutrition 2009;102: 419–427.

    Article  CAS  Google Scholar 

  22. Prevention CfDCa National Health and Nutrition Examination Survey https://wwwn.cdc.gov/nchs/nhanes/default.aspx Accessed 27 February 2019

  23. Centers for Disease C, and Prevention National Health and Nutrition Examination Survey 2011–2012 https://wwwn.cdc.gov/Nchs/Nhanes/2011-2012/CFQ_G.htm Accessed 27 February

  24. Nooyens AC, Bueno-de-Mesquita HB, van Boxtel MP, et al. Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. The British journal of nutrition 2011;106: 752–61.

    Article  CAS  Google Scholar 

  25. Association AD (2015) (2) Classification and diagnosis of diabetes. Diabetes Care 38Suppl: S8–s16.

    Article  Google Scholar 

  26. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal of the American College of Cardiology 2018;71: e127–e248.

    Article  Google Scholar 

  27. Centers for Disease C, and Prevention. National Health and Nutrition Examination Survey: Analytic Guidelines, 2011–2014 and 2015–2016 https://wwwn.cdc.gov/nchs/data/nhanes/2011-2012/analyticguidelines/analytic_guidelines_11_16.pdf Accessed 27 February

  28. Fernstrom JD, Fernstrom MH. Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. The Journal of nutrition 2007;137: 1539S–1547S; discussion 1548S.

    Article  CAS  Google Scholar 

  29. Bourre JM. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients. The journal of nutrition, health & aging 2006;10: 386–99.

    CAS  Google Scholar 

  30. Fernstrom JD. Large neutral amino acids: dietary effects on brain neurochemistry and function. Amino acids 2013;45: 419–30.

    Article  CAS  Google Scholar 

  31. Young VR. Amino acids and proteins in relation to the nutrition of elderly people. Age and ageing 1990;19: S10–24.

    Article  CAS  Google Scholar 

  32. Requejo AM, Ortega RM, Robles F, et al. Influence of nutrition on cognitive function in a group of elderly, independently living people. Eur J Clin Nutr 2003;57Suppl 1: S54–7.

    Article  CAS  Google Scholar 

  33. Petruski-Ivleva N, Kucharska-Newton A, Palta P, et al. Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study. Nutrients 2017;9.

  34. Almeida OP, Norman P, Hankey G, et al. Successful mental health aging: results from a longitudinal study of older Australian men. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry 2006;14: 27–35.

    Article  Google Scholar 

  35. Kesse-Guyot E, Assmann KE, Andreeva VA, et al. Consumption of Dairy Products and Cognitive Functioning: Findings from the SU.VI.MAX 2 Study. J Nutr Health Aging 2016;20: 128–37.

    Article  CAS  Google Scholar 

  36. Pilleron S, Desport JC, Jesus P, et al. Diet, Alcohol Consumption and Cognitive Disorders in Central Africa: A Study from the EPIDEMCA Program. J Nutr Health Aging 2015;19: 657–67.

    Article  CAS  Google Scholar 

  37. Vercambre MN, Boutron-Ruault MC, Ritchie K, et al. Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women. The British journal of nutrition 2009;102: 419–27.

    Article  CAS  Google Scholar 

  38. Araki A, Yoshimura Y, Sakurai T, et al. Low intakes of carotene, vitamin B2, pantothenate and calcium predict cognitive decline among elderly patients with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int 2017;17: 1168–1175.

    Article  Google Scholar 

  39. Ozawa M, Ohara T, Ninomiya T, et al. Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. J Am Geriatr Soc 2014;62: 1224–30.

    Article  Google Scholar 

  40. Park KM, Fulgoni VL, 3rd. The association between dairy product consumption and cognitive function in the National Health and Nutrition Examination Survey. The British journal of nutrition 2013;109: 1135–42.

    Article  CAS  Google Scholar 

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Acknowledgement

We thank all individuals at the National Center for Health Statistics of the Centers for Disease Control and Prevention who were responsible for the planning and administering of NHANES and making the datasets of NHANES available on their website.

Author information

Authors and Affiliations

  1. Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, Shandong, China

    Y. Li, S. Li, W. Wang & Dongfeng Zhang

Authors
  1. Y. Li
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  2. S. Li
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  3. W. Wang
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  4. Dongfeng Zhang
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Contributions

Author Contributions: D.Z. had full access to all study data and take responsibility for their integrity and accuracy of statistical analysis. Study concept and design: Y.L, D.Z. Acquisition, analysis, or interpretation of data: All authors. Manuscript first draft: Y.L. Critical revision of the manuscript for important intellectual content: Y.L, S.L, W.W, D.Z. Statistical analysis: Y.L, S.L, W.W. Technical and material support: Y.L, S.L, W.W. Supervision: S.L, W.W, D.Z. All the authors have approved the final article.

Corresponding author

Correspondence to Dongfeng Zhang.

Ethics declarations

Financial support: No financial support.

Conflict of interest: The authors have no conflicts of interest to declare.

Statement of Ethics: This study was approved by the National Center for Health Statistics Research ethics review board and performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All persons gave their informed consent prior to their inclusion in the study.

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Li, Y., Li, S., Wang, W. et al. Association between Dietary Protein Intake and Cognitive Function in Adults Aged 60 Years and Older. J Nutr Health Aging 24, 223–229 (2020). https://doi.org/10.1007/s12603-020-1317-4

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  • DOI: https://doi.org/10.1007/s12603-020-1317-4

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