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Ionized and Total Magnesium Levels Change during Repeated Exercise in Older Adults

Abstract

Background

Magnesium is essential for health and performance. Sub-optimal levels have been reported for older persons. In addition, physical exercise is known to temporally decrease magnesium blood concentrations.

Objective

To investigate these observations in conjunction we assessed total (tMg) and ionized magnesium (iMg) concentrations in plasma and whole blood, respectively, during 4 consecutive days of exercise in very old vital adults. Design: 68 participants (age 83.7±1.9 years) were monitored on 4 consecutive days at which they walked 30–40km (average ∼8 hours) per day at a self-determined pace. Blood samples were collected one or two days prior to the start of exercise (baseline) and every walking day immediately post-exercise. Samples were analysed for tMg and iMg levels.

Results

Baseline tMg and iMg levels were 0.85±0.07 and 0.47±0.07 mmol/L, respectively. iMg decreased after the first walking day (−0.10±0.09 mmol/L, p<.001), increased after the second (+0.11±0.07 mmol/L, p<.001), was unchanged after the third and decreased on the final walking day, all compared to the previous day. tMg was only higher after the third walking day compared to the second walking day (p=.012). In 88% of the participants, iMg levels reached values considered to be sub-optimal at day 1, in 16% of the participants values were sub-optimal for tMg at day 2.

Conclusion

Prolonged moderate intensity exercise caused acute effects on iMg levels in a degree comparable to that after a bout of intensive exercise. These effects were not associated with drop-out or health problems. After the second consecutive day of exercise, levels were returned to baseline values, suggesting rapid adaptation/resilience in this population.

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Figure 1

Abbreviations

ANOVA:

Analysis of variance

BMI:

Body mass index

HR:

heart rate

iMg:

ionized magnesium

LH:

Lithium heparine

Mg:

magnesium

Rpm:

Revolutions per minute

tMg:

total magnesium

References

  1. de Baaij, J.H., J.G. Hoenderop, and R.J. Bindels, Magnesium in man: implications for health and disease. Physiol Rev, 2015. 95(1): p. 1–46.

    Article  CAS  PubMed  Google Scholar 

  2. Finstad, E.W., et al., The effects of magnesium supplementation on exercise performance. Med Sci Sports Exerc, 2001. 33(3): p. 493–8.

    Article  CAS  PubMed  Google Scholar 

  3. Lukaski, H.C., Magnesium, zinc, and chromium nutriture and physical activity. Am J Clin Nutr, 2000. 72(2 Suppl): p. 585s–93s.

    Article  CAS  PubMed  Google Scholar 

  4. Lukaski, H.C., Vitamin and mineral status: effects on physical performance. Nutrition, 2004. 20(7–8): p. 632–44.

    Article  CAS  PubMed  Google Scholar 

  5. Konishi, M., Cytoplasmic free concentrations of Ca2+ and Mg2+ in skeletal muscle fibers at rest and during contraction. Jpn J Physiol, 1998. 48(6): p. 421–38.

    Article  CAS  PubMed  Google Scholar 

  6. Singh, R.B., et al., Mechanisms of acute myocardial infarction study (MAMIS). Biomed Pharmacother, 2004. 58Suppl 1: p. S111–5.

    Article  PubMed  Google Scholar 

  7. Welch, A.A., et al., Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women. J Bone Miner Res, 2016. 31(2): p. 317–25.

    Article  CAS  PubMed  Google Scholar 

  8. Barbagallo, M., M. Belvedere, and L.J. Dominguez, Magnesium homeostasis and aging. Magnes Res, 2009. 22(4): p. 235–46.

    CAS  PubMed  Google Scholar 

  9. Durlach, J., et al., Magnesium status and ageing: an update. Magnes Res, 1998. 11(1): p. 25–42.

    CAS  PubMed  Google Scholar 

  10. Park, C.H., et al., The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis. PLoS One, 2014. 9(11): p. e112558.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Elin, R.J., Assessment of magnesium status for diagnosis and therapy. Magnes Res, 2010. 23(4): p. S194–8.

    PubMed  Google Scholar 

  12. Buchman, A.L., et al., The effect of a marathon run on plasma and urine mineral and metal concentrations. J Am Coll Nutr, 1998. 17(2): p. 124–7.

    Article  CAS  PubMed  Google Scholar 

  13. Scherr, J., et al., Repolarization perturbation and hypomagnesemia after extreme exercise. Med Sci Sports Exerc, 2012. 44(9): p. 1637–43.

    Article  CAS  PubMed  Google Scholar 

  14. Mooren, F.C., et al., Alterations of ionized Mg2+ in human blood after exercise. Life Sci, 2005. 77(11): p. 1211–25.

    Article  CAS  PubMed  Google Scholar 

  15. Terink, R., et al., Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores Within Hours - Potential Consequences for Monitoring and Supplementation. Int J Sport Nutr Exerc Metab, 2016: p. 1–22.

  16. Durlach, J., et al., Importance of the ratio between ionized and total Mg in serum or plasma: new data on the regulation of Mg status and practical importance of total Mg concentration in the investigation of Mg imbalance. Magnes Res, 2002. 15(3–4): p. 203–5.

    CAS  PubMed  Google Scholar 

  17. Ising, H., et al., Measurement of free magnesium in blood, serum and plasma with an ion-sensitive electrode. Eur J Clin Chem Clin Biochem, 1995. 33(6): p. 365–71.

    CAS  PubMed  Google Scholar 

  18. Tanaka, H., K.D. Monahan, and D.R. Seals, Age-predicted maximal heart rate revisited. J Am Coll Cardiol, 2001. 37(1): p. 153–6.

    Article  CAS  PubMed  Google Scholar 

  19. Dill, D.B. and D.L. Costill, Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol, 1974.37(2): p. 247–8.

    Article  CAS  Google Scholar 

  20. American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription: Lippincott Williams & Wilkins; 2013. p 5.

    Google Scholar 

  21. Rayana, M.C., et al., Guidelines for sampling, measuring and reporting ionized magnesium in undiluted serum, plasma or blood: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division, Committee on Point of Care Testing. Clin Chem Lab Med, 2005. 43(5): p. 564–9.

    PubMed  Google Scholar 

  22. Rakhra, G., et al., Effect of physical activity and age on plasma copper, zinc, iron, and magnesium concentration in physically active healthy males. Nutrition, 2017. 43–44: p. 75–82.

    Article  CAS  PubMed  Google Scholar 

  23. Khan, M.U., B.O. Komolafe, and K.T. Weber, Cation interdependency in acute stressor states. Am J Med Sci, 2013. 345(5): p. 401–4.

    Article  PubMed  Google Scholar 

  24. Vormann J, Förster R, Günther T, Ebel H, editors. Lipolysis induced magnesium uptake into fat-cells. Magnesium-bulletin; 1982: 201–2.

  25. Franz, K.B., et al., Physiologic changes during a marathon, with special reference to magnesium. J Am Coll Nutr, 1985. 4(2): p. 187–94.

    Article  CAS  PubMed  Google Scholar 

  26. Singh, R. and R.G. Sirisinghe, Haematological and plasma electrolyte changes after long distance running in high heat and humidity. Singapore Med J, 1999. 40(2): p. 84–7.

    CAS  PubMed  Google Scholar 

  27. Convertino, V.A., Blood volume response to physical activity and inactivity. Am J Med Sci, 2007. 334(1): p. 72–9.

    Article  PubMed  Google Scholar 

  28. Warburton, D.E., et al., Biochemical changes as a result of prolonged strenuous exercise. Br J Sports Med, 2002. 36(4): p. 301–3.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Saris, N.E., et al., Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta, 2000. 294(1–2): p. 1–26.

    Article  CAS  Google Scholar 

  30. Feeney, K.A., et al., Daily magnesium fluxes regulate cellular timekeeping and energy balance. Nature, 2016. 532(7599): p. 375–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Rieneke Terink.

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Terink, R., Balvers, M.G., Bongers, C.C.W.G. et al. Ionized and Total Magnesium Levels Change during Repeated Exercise in Older Adults. J Nutr Health Aging 23, 595–601 (2019). https://doi.org/10.1007/s12603-019-1205-y

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  • DOI: https://doi.org/10.1007/s12603-019-1205-y

Key words

  • Older adults
  • consecutive exercise days
  • micronutrients
  • reference values