Abstract
Background
Several previous researches had found artery stiffness associated skeletal muscle mass, but not considering muscle strength and physical performance, which also were compositions of sarcopenia. This study aims to reveal the relationship of artery stiffness and sarcopenia using the Asian Working Group for Sarcopenia criteria.
Methods
Study was performed on 1002 Chinese community dwelling participants aged ≥65 years from November 2016 to March 2017. Body composition, muscle strength, physical performance, and brachial-ankle pulse wave velocity (baPWV) considering as artery stiffness index were measured.
Results
In multiple regression analysis, baPWV was associated with handgrip (β=−0.13, P=0.04) and Relative skeletal muscle mass index (ASM/Ht2) (β=−0.02, P<0.01), but not with 4-meter velocity (P=0.21). Multiple logistic regression analysis showed that 1-SD (3.50m/s) increased in baPWV was still associated with a 11% (CI, 4%–20%; P<0.01) higher odds of being sarcopenia. In the gender subgroup analysis, the relationship of baPWV and sarcopenia remain significant in men (OR, 1.23; 95% CI, 1.07–1.42, P<0.01), but not in women (P=0.07).
Conclusions
High brachial-ankle pulse wave velocity is associated with sarcopenia in Chinese community-dwelling elderly, with gender differences.
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References
Sampaio RA, Sewo Sampaio PY, et al. Arterial stiffness is associated with low skeletal muscle mass in Japanese community-dwelling older adults. Geriatr Gerontol Int. 2014;14 suppl 1:109–114. doi: 10.1111/ggi.12206.
He H, Liu Y, Tian Q, et al. Relationship of sarcopenia and body composition with osteoporosis. Osteoporos Int. 2016;27:473–482. doi: 10.1007/s00198-015-3241-8.
Lim S, Kwon SY, Yoon JW, et al. Association between body composition and pulmonary function in elderly people: The Korean Longitudinal Study on Health and Aging. Obesity (Silver Spring). 2011;19:631–638. doi: 10.1038/oby.2010.167.
Miller JA, Harris K, Roche C, et al. Sarcopenia is a predictor of outcomes after lobectomy. J Thorac Dis. 2018;10:432–440. doi: 10.21037/jtd.2017.12.39.
Sajyna K, Yamaguchi A. Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2012;3:77–94. doi: 10.1007/s13539-011-0052-4.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on of definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412–423. doi: 10.1093/ageing/afq034.
Chhetri JK, de Souto Barreto P, et al. Chronic inflammation and sarcopenia: A regenerative cell therapy perspective. Exp Gerontol. 2018;103:115–123. doi: 10.1016/j. exger.2017.12.023.
Hingorani AD, Cross J, Kharbanda RK, et al. Acute systemic inflammation impairs endothelium-dependen dilatation in humans. Circulation. 2000;102:994–999. doi: 10.1161/01.CIR.102.9.994.
Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25:932–943. doi: 10.1161/01. ATV.0000160548.78317.29.
Sakuragi S, Abhayaratna WP. Arterial stiffness: methods of measurement, physiologic determinants and prediction of cardiovascular outcomes. Int J Cardiol. 2010;138:112–118. doi: 10.1016/j.ijcard.2009.04.027.
Willum-Hansen T, Staessen JA, Torp-Pedersen C, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation. 2006;113:664–670. doi: 10.1161/CIRCULATIONAHA.105.579342.
Anderson JL, Halperin JL, Albert NM, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127:1425–1443. doi: 10.1161/CIR.0b013e31828b82aa.
Tanaka KI, Kanazawa I, Sugimoto T. Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2016;122:141–147. doi: 10.1016/j.diabres.2016.10.014.
Sampaio RA, Sewo Sampaio PY, Yamada M, et al. Arterial stiffness is associated with low skeletal muscle mass in Japanese community-dwelling older adults. Geriatr Gerontol Int. 2014;Suppl 1:109–114. doi: 10.1111/ggi.12206.
Abbatecola AM, Chiodini P, Gallo C, et al. Pulse wave velocity is associated with muscle mass decline: Health ABC study. Age. 2012;34:469–478. doi: 10.1007/s11357-011-9238-0.
Kohara K, Ochi M, Tabara Y, et al. Arterial stiffness in sarcopenia visceral obesity in the elderly: J-SHIPP study. Int J Cardiol. 2012;158:146–148. doi: 10.1016/j. ijcard.2012.04.033.
Lau EM, Lynn HS, Woo JW, et al. Prevalence of and risk factors for sarcopenia in elderly Chinese men and women. J Gerontol A Biol Sci Med Sci. 2005;60:213–216. doi: 10.1093/gerona/60.2.213.
Anoop S, Misra A, Bhardwaj S, et al. High body fat and low muscle mass are associated with increased arterial stiffness in Asian Indians in North India. J Diabetes Complication. 2015;29:38–43. doi: 10.1016/j.jdiacomp.2014.08.001.
Ochi M, Kohara K, Tabara Y, et al. Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men. Atherosclerosis. 2010;212:327–332. doi: 10.1016/j.atherosclerosis.2010.05.026.
Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian working Group for sarcopenia. J Am Med Dir Assor. 2014;15:95–101. doi: 10.1016/j. jamda.2013.11.025.
Malavoli M, Mussi C, Poli M, et al. Cross-calibration of eight-polar bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for the assessment of total and appendicualr body composition in healthy subjects aged 21–82 years. Ann Hum Biol. 2003;30:380–391. doi: 10.1080/0301446031000095211.
Cawthon PM, Peters KW, Shardell MD, et al. Cutpoints for low appendicualr lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci. 2014;69:567–575. doi: 10.1093/gerona/glu023.
Zhang W, Shen S, Wang W, et al. Poor lower extremity function was associated with pre-diabetes and diabetes in older chinese people. PLos One. 2014;9:e115883. doi: 10.1371/journal.pone.0115883.
O’Brien E, Asmar R, Beilin L, et al. Practice guidelines of the European Society of Hypertension for clinic, ambulatory and self blood pressure measurement. J Hypertens. 2005;23:697–701. doi: 10.1097/01.hjh.0000163132.84890.
Yoshida N, Okumura K, Aso Y. High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes. Metabolism. 2005;54:345–350. doi: 10.1016/j.metabol.2004.09.014.
Tanaka K, Kanazawa I, Sugomoto T. Elvated serum pentosidine and decreasedserum IGF-I levels are associated with loss of muscle mass in postmenopausal women with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2016;124:163–166. doi: 10.1055/s-0035-1565103.
Tabara Y, Igase M, Kido T, et al. Composition of lower extremity in relation to a high ankle-brachial index. J Hypertens. 2009;27:167–173. doi: 10.1097/HJH.0b013e328314b821.
Hougaku H, Fleg JL, Najjar SS, et al. Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements. Am j physiol Endocrinol Metab. 2006;290:e234–242. doi: 10.1152/ajpendo.00059.2005.
Lee M, Choh AC, Demerath EW, et al. Associations between trunk, leg and totla body adiposity with arterial stiffness. Am J Hypertens. 2012;25:1131–1137. doi: 10.1038/ajh.2012.92.
Fu S, Luo L, Ye P, et al. Overall and abdominal obesity indicators had different association with central arterial stiffness and hemodynamics independent of age, sex, blood pressure, glucose, and lipids in Chinese community-dwelling adults. Clin Interv Aging. 2013;8:1579–1584. doi: 10.2147/CIA.S54352.
Watson NL, Sutton-Tyrrell K, Youk AO, et al. Arterial stiffness and gait speed in older adults with and without peripheral arterial disease. Am J Hypertens. 2011;24:90–95. doi: 10.1038/ajh.2010.193.
Brunner EJ, Shipley MJ, Witte DR, et al. Arterial stiffness, physical function, and functional limitation: the Whitehall II Study. Hypertension. 2011;57:1003–1009. doi: 10.1161/HYPERTENSIONAHA.110.168864.
Mattace-Raso FU, van der Cammen TJ, Hofman A, et al. Arterial stiffness and risk of coronary heart disease and stroke: The rotterdam study. Circulation. 2006;113:657–663. doi: 10.1161/CIRCULATIONAHA.105.555235.
van Dijk SC, Swart KM, Ham AC, et al. Physical Fitness, Activity and Hand-Grip Strength Are Not Associated with Arterial Stiffness in Older Individuals. J Nutr Health Aging. 2015;19:779–784. doi: 10.1007/s12603-015-0519-7.
Volpato S, Bianchi L, Cherubini A, et al. Prevalence and clinical correlates of sarcopenia in community-dwelling older people: application of the EWGSOP definition and diagnostic algorithm. J Gerontol A Biol Sci Med Sci. 2014;69:438–446. doi: 10.1093/gerona/glt149.
Alexandre Tda S, Duarte YA, Santos JL, et al. Prevalence and associated factors of sarcopenia among elderly in Brazil: findings from the SABE study. J Nutr Health Aging. 2014;18:284–290. doi: 10.1007/s12603-013-0413-0.
Han PP, Kang L, Guo Q, et al. Prevalence and Factors Associated with Sarcopenia in Suburb-dwelling older Chinese Using the Asian Working Group for Sarcopenia Definition. J Gerontol A Biol Sci Med Sci. 2016;71:529–535. doi: 10.1093/gerona/glv108.
Cheng Q, Zhu X, Zhang X, et al. A cross-sectional study of loss of muscle mass corresponding to sarcopenia in healthy Chinese men and women: reference values, prevalence, and association with bone mass. J Bone Miner Metab. 2014;32:78–88. doi: 10.1007/s00774-013-0468-3.
Jørgensen L, Jacobsen BK. Changes in muscle mass, fat mass, and bone mineral content in the legsafter stroke: A 1-year prospective study. Bone. 2001;28:655–659. doi: https://doi.org/10.1016/S8756-3282(01)00434-3.
Ryan AS, Buscemi A, Forrester L, et al. Atrophy and intramuscular fat in specific muscles of the thigh: Associated weakness and hyperinsulinemia in stroke survivor. Neurorehabil Neural Repair. 2011;25:865–872. doi: 10.1177/1545968311408920.
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Zhang, L., Guo, Q., Feng, BL. et al. A Cross-Sectional Study of the Association Between Arterial Stiffness and Sarcopenia in Chinese Community-Dwelling Elderly Using the Asian Working Group for Sarcopenia Criteria. J Nutr Health Aging 23, 195–201 (2019). https://doi.org/10.1007/s12603-018-1147-9
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DOI: https://doi.org/10.1007/s12603-018-1147-9