MIND Diet Associated with Reduced Incidence and Delayed Progression of Parkinsonism in Old Age

Abstract

Background

In old age, motor impairments including parkinsonian signs are common, but treatment is lacking for many older adults. In this study, we examined the association of a diet specifically developed to promote brain health, called MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay), to the incidence and progression of parkinsonism in older adults.

Methods

A total of 706 Memory and Aging Project participants aged 59–97 years and without parkinsonism at baseline were assessed annually for the presence of four parkinsonian signs using a 26-item modified version of the United Parkinson’s Disease Rating Scale. Incident parkinsonism was defined as the first occurrence over 4.6 years of follow-up of two or more parkinsonian signs. The progression of parkinsonism was assessed by change in a global parkinsonian score (range: 0-100). MIND, Mediterranean, and DASH diet pattern scores were computed based on a validated food frequency questionnaire including 144 food items. We employed Cox-Proportional Hazard models and linear mixed models, to examine the associations of baseline diet scores with incident parkinsonism and the annual rate of change in global parkinsonian score, respectively.

Results

In models adjusted for age, sex, smoking, total energy intake, BMI and depressive symptoms, higher MIND diet scores were associated with a decreased risk of parkinsonism [(HR=0.89, 95% CI 0.83-0.96)]; and a slower rate of parkinsonism progression [(β= -0.008; SE=0.0037; p=0.04)]. The Mediterranean diet was marginally associated with reduced parkinsonism progression (β= -0.002; SE=0.0014; p=0.06). The DASH diet, by contrast, was not associated with either outcome.

Conclusion

The MIND diet created for brain health may be a associated with decreased risk and slower progression of parkinsonism in older adults.

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References

  1. 1.

    Buchman AS, Wilson RS, Shulman JM, Leurgans SE, Schneider JA, Bennett DA: Parkinsonism in Older Adults and Its Association With Adverse Health Outcomes and Neuropathology. J Gerontol A Biol Sci Med Sci 2016, 71(4):549–556.

    Article  PubMed  Google Scholar 

  2. 2.

    Buchman AS, Leurgans SE, Nag S, Bennett DA, Schneider JA: Cerebrovascular disease pathology and parkinsonian signs in old age. Stroke 2011, 42(11):3183–3189.

    Article  PubMed  PubMed Central  Google Scholar 

  3. 3.

    Buchman AS, Shulman JM, Nag S, Leurgans SE, Arnold SE, Morris MC, Schneider JA, Bennett DA: Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann Neurol 2012, 71(2):258–266.

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Fleischman DA, Wilson RS, Schneider JA, Bienias JL, Bennett DA: Parkinsonian signs and functional disability in old age. Exp Aging Res 2007, 33(1):59–76.

    Article  PubMed  Google Scholar 

  5. 5.

    Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT: MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement 2015, 11(9):1007–1014.

    Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT: MIND diet slows cognitive decline with aging. Alzheimers Dement 2015, 11(9):1015–1022.

    Article  PubMed  PubMed Central  Google Scholar 

  7. 7.

    Bennett DA, Schneider JA, Buchman AS, Barnes LL, Boyle PA, Wilson RS: Overview and findings from the rush Memory and Aging Project. Current Alzheimer research 2012, 9(6):646–663.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. 8.

    Bennett DA, Shannon KM, Beckett LA, Goetz CG, Wilson RS: Metric properties of nurses’ ratings of parkinsonian signs with a modified Unified Parkinson’s Disease Rating Scale. Neurology 1997, 49(6):1580–1587.

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Bennett DA, Shannon KM, Beckett LA, Wilson RS: Dimensionality of parkinsonian signs in aging and Alzheimer’s disease. J Gerontol A Biol Sci Med Sci 1999, 54(4): M191–196.

    Article  CAS  PubMed  Google Scholar 

  10. 10.

    Morris MC, Tangney CC, Bienias JL, Evans DA, Wilson RS: Validity and reproducibility of a food frequency questionnaire by cognition in an older biracial sample. American journal of epidemiology 2003, 158(12):1213–1217.

    Article  PubMed  Google Scholar 

  11. 11.

    Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C: Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med 2007, 44(4):335–340.

    Article  PubMed  Google Scholar 

  12. 12.

    Tangney CC, Li H, Wang Y, Barnes L, Schneider JA, Bennett DA, Morris MC: Relation of DASH–and Mediterranean–like dietary patterns to cognitive decline in older persons. Neurology 2014, 83(16):1410–1416.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. 13.

    Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Shah RC, Schneider JA, Arnold SE, Bennett DA: Brainstem aminergic nuclei and late–life depressive symptoms. JAMA psychiatry 2013, 70(12):1320–1328.

    Article  PubMed  Google Scholar 

  14. 14.

    Wilson RS, Krueger KR, Arnold SE, Schneider JA, Kelly JF, Barnes LL, Tang Y, Bennett DA: Loneliness and risk of Alzheimer disease. Archives of general psychiatry 2007, 64(2):234–240.

    Article  PubMed  Google Scholar 

  15. 15.

    Buchman AS, Leurgans SE, Yu L, Wilson RS, Lim AS, James BD, Shulman JM, Bennett DA: Incident parkinsonism in older adults without Parkinson disease. Neurology 2016, 87(10):1036–1044.

    Article  PubMed  PubMed Central  Google Scholar 

  16. 16.

    Gao X, Chen H, Fung TT, Logroscino G, Schwarzschild MA, Hu FB, Ascherio A: Prospective study of dietary pattern and risk of Parkinson disease. The American journal of clinical nutrition 2007, 86(5):1486–1494.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. 17.

    Alcalay RN, Gu Y, Mejia–Santana H, Cote L, Marder KS, Scarmeas N: The association between Mediterranean diet adherence and Parkinson’s disease. Mov Disord 2012, 27(6):771–774.

    Article  PubMed  PubMed Central  Google Scholar 

  18. 18.

    Okubo H, Miyake Y, Sasaki S, Murakami K, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T et al: Dietary patterns and risk of Parkinson’s disease: a case–control study in Japan. Eur J Neurol 2012, 19(5):681–688.

    Article  CAS  PubMed  Google Scholar 

  19. 19.

    Saaksjarvi K, Knekt P, Lundqvist A, Mannisto S, Heliovaara M, Rissanen H, Jarvinen R: A cohort study on diet and the risk of Parkinson’s disease: the role of food groups and diet quality. Br J Nutr 2013, 109(2):329–337.

    Article  CAS  PubMed  Google Scholar 

  20. 20.

    Milaneschi Y, Bandinelli S, Corsi AM, Lauretani F, Paolisso G, Dominguez LJ, Semba RD, Tanaka T, Abbatecola AM, Talegawkar SA et al: Mediterranean diet and mobility decline in older persons. Exp Gerontol 2011, 46(4):303–308.

    Article  PubMed  Google Scholar 

  21. 21.

    Shahar DR, Houston DK, Hue TF, Lee JS, Sahyoun NR, Tylavsky FA, Geva D, Vardi H, Harris TB: Adherence to mediterranean diet and decline in walking speed over 8 years in community–dwelling older adults. J Am Geriatr Soc 2012, 60(10):1881–1888.

    Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Leon–Munoz LM, Guallar–Castillon P, Lopez–Garcia E, Rodriguez–Artalejo F: Mediterranean diet and risk of frailty in community–dwelling older adults. J Am Med Dir Assoc 2014, 15(12):899–903.

    Article  PubMed  Google Scholar 

  23. 23.

    Shukitt–Hale B, Bielinski DF, Lau FC, Willis LM, Carey AN, Joseph JA: The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing. Br J Nutr 2015, 114(10):1542–1549.

    Article  CAS  PubMed  Google Scholar 

  24. 24.

    Schrager MA, Hilton J, Gould R, Kelly VE: Effects of blueberry supplementation on measures of functional mobility in older adults. Appl Physiol Nutr Metab 2015, 40(6):543–549.

    Article  CAS  PubMed  Google Scholar 

  25. 25.

    Zhang SM, Hernan MA, Chen H, Spiegelman D, Willett WC, Ascherio A: Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002, 59(8):1161–1169.

    Article  CAS  PubMed  Google Scholar 

  26. 26.

    Miyake Y, Fukushima W, Tanaka K, Sasaki S, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N et al: Dietary intake of antioxidant vitamins and risk of Parkinson’s disease: a case–control study in Japan. Eur J Neurol 2011, 18(1):106–113.

    Article  CAS  PubMed  Google Scholar 

  27. 27.

    Logroscino G, Marder K, Cote L, Tang MX, Shea S, Mayeux R: Dietary lipids and antioxidants in Parkinson’s disease: a population–based, case–control study. Ann Neurol 1996, 39(1):89–94.

    Article  CAS  PubMed  Google Scholar 

  28. 28.

    Scheider WL HL, Vena JE, Holmlund T, Marshall JR, Freudenheim.: Dietary antioxidants and other dietary factors in the etiology of Parkinson’s disease. Mov Disord 1997, Mar(12(2)): 190–196.

    Google Scholar 

  29. 29.

    Cesari M, Pahor M, Bartali B, Cherubini A, Penninx BW, Williams GR, Atkinson H, Martin A, Guralnik JM, Ferrucci L: Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. The American journal of clinical nutrition 2004, 79(2):289–294.

    Article  CAS  PubMed  Google Scholar 

  30. 30.

    Bartali B, Curto T, Maserejian NN, Araujo AB: Intake of antioxidants and subsequent decline in physical function in a racially/ethnically diverse population. The journal of nutrition, health & aging 2015, 19(5):542–547.

    Article  CAS  Google Scholar 

  31. 31.

    Martinez–Gonzalez MA, Salas–Salvado J, Estruch R, Corella D, Fito M, Ros E: Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Progress in cardiovascular diseases 2015, 58(1):50–60.

    Article  PubMed  Google Scholar 

  32. 32.

    Asemi Z, Samimi M, Tabassi Z, Shakeri H, Sabihi SS, Esmaillzadeh A: Effects of DASH diet on lipid profiles and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome: a randomized clinical trial. Nutrition (Burbank, Los Angeles County, Calif) 2014, 30(11–12): 1287–1293.

    Article  CAS  Google Scholar 

  33. 33.

    Dexter DT, Jenner P: Parkinson disease: from pathology to molecular disease mechanisms. Free radical biology & medicine 2013, 62:132–144.

    Google Scholar 

  34. 34.

    Tiwari PC, Pal R: The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues in clinical neuroscience 2017, 19(1):71–80.

    PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Puja Agarwal.

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Agarwal, P., Wang, Y., Buchman, A.S. et al. MIND Diet Associated with Reduced Incidence and Delayed Progression of Parkinsonism in Old Age. J Nutr Health Aging 22, 1211–1215 (2018). https://doi.org/10.1007/s12603-018-1094-5

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Key words

  • Parkinsonism
  • motor decline
  • dietary pattern
  • longitudinal
  • MIND diet