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The journal of nutrition, health & aging

, Volume 22, Issue 9, pp 1128–1132 | Cite as

Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial

  • Cynthia El HajjEmail author
  • J.-M. Chardigny
  • Y. Boirie
  • K. Yammine
  • M. Helou
  • S. Walrand
Article

Abstract

Background

A low serum 25-hydroxyvitamin D [(25(OH) D)] concentration was shown to correlate with higher fasting blood glucose (FBG) and insulin levels. Since age affect insulin sensitivity and the metabolism, we aimed in this randomized controlled trial to investigate the effect of vitamin D supplementation on glucose homeostasis and index of insulin resistance in elderly subjects living in Beirut, Lebanon.

Methods

Participants (n= 115) deficient in vitamin D were randomly divided into two groups, a group receiving 30,000 IU cholecalciferol/week for a period of 6 months, and a placebo group. The index of insulin resistance HOMA (homeostasis model assessment) was the primary outcome. Glucose homeostasis and metabolic markers were also measured at start of treatment and at 6 months.

Results

Vitamin D supplementation led to significant improvements in blood levels of [25(OH) D] (P< 0.0001), and a significant decreased of HOMA, PTH and FBG concentrations (P< 0.0001) in the intervention group compared to placebo. No significant changes were observed in HbA1c levels for both groups. Total cholesterol and LDL cholesterol concentrations have also decreased significantly in the intervention group (P< 0.0001).

Conclusion

Short-term supplementation with cholecalciferol improved vitamin D status, and markers of insulin resistance in healthy elder population. This trial was registered at ClinicalTrials.gov; Identifier number#:NCT03478475

Key words

Vitamin D HOMA-IR glucose HbA1c insulin resistance 

Abbreviations

25(OH)D

25-hydroxyvitamin D

BMI

body mass index

FBG

fasting blood glucose

HbA1c

glycated hemoglobin

HOMA

homeostatic model assessment

IR

insulin resistance

PTH

parathyroid hormone

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Copyright information

© Serdi and Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  • Cynthia El Hajj
    • 1
    • 2
    Email author
  • J.-M. Chardigny
    • 2
  • Y. Boirie
    • 2
    • 3
  • K. Yammine
    • 4
    • 5
  • M. Helou
    • 6
  • S. Walrand
    • 2
  1. 1.Département de Diététique et de NutritionHôpital Saint-CharlesBeirutLebanon
  2. 2.INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-FerrandFrance Clermont Université, Université d’Auvergne, Unité de NutritionClermont-FerrandFrance
  3. 3.CHU Clermont-Ferrand, Service de Nutrition CliniqueClermont-FerrandFrance
  4. 4.Department of Orthopedic SurgeryLebanese American University-Rizk HospitalBeirutLebanon
  5. 5.Center for Evidence-based Anatomy, Sports & Orthopedic ResearchJdeidehLebanon
  6. 6.Department of Medicine, School of MedicineLebanese American UniversityBeirutLebanon

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