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Association between Cognitive Impairment, Vascular Disease and All-Cause Mortality

  • Published:
The journal of nutrition, health & aging

Abstract

Objective

The purpose of this study was to investigate the association between elder’s cognitive impairment and mortality. Additionally, interaction between cognitive impairment and cardio- and cerebrovascular diseases was considered.

Methods

Data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2014 was assessed using 10,026 participants at baseline with no missing information. Chi-square test, log-rank test, and Cox proportional hazards models were used to investigate the association between cognitive impairment and mortality.

Results

Cognitive impairment was significantly associated with mortality. With normal cognitive functioning group as reference: HR=2.329 (p<.0001) for severe cognitive impairment, HR=1.238 (p.009) for mild cognitive impairment. The association remained significant even after considering for cardio- and cerebrovascular diseases.

Conclusion

This study provided additional support to previous findings in regards to the relationship between cognitive impairment and mortality. Worse cognitive functioning increased the risk of mortality and the presence of cardio- and cerebrovascular diseases exacerbated this relationship.

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Authors and Affiliations

  1. Department of Health Administration, College of Health Science, Dankook University, Cheonan, Korea

    J.-H. Kim

  2. Institute of Health Promotion and Policy, Dankook University, Cheonan, Korea

    J.-H. Kim

  3. Department of Preventive Medicine and Public Health, Ajou University School of Medicine, Suwon, Republic of Korea

    Doukyoung Chon

  4. Institute on Aging, Ajou University Medical Center, Suwon, Republic of Korea

    Doukyoung Chon

Authors
  1. J.-H. Kim
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  2. Doukyoung Chon
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Correspondence to Doukyoung Chon.

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Kim, JH., Chon, D. Association between Cognitive Impairment, Vascular Disease and All-Cause Mortality. J Nutr Health Aging 22, 790–795 (2018). https://doi.org/10.1007/s12603-018-1011-y

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  • DOI: https://doi.org/10.1007/s12603-018-1011-y

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