Associations between Plasmatic Polyunsaturated Fatty Acids Concentrations and Cognitive Status and Decline in Neurocognitive Disorders
- 113 Downloads
To examine the association of plasmatic and erythrocyte concentrations polyunsaturated fatty acids (PUFA) with both cognitive status and decline.
Longitudinal observational cohort study. Setting: Memory Clinic of Lyon Sud university hospital.
140 patients, aged 60 and older, were referred to the memory clinic, and successively included in the cohort, between March 2010 and February 2014.
Concentration of ω-3 PUFA (eicosapentaenoic: EPA and docosahexaenoic: DHA) and ω-6 PUFA (arachidonic: AA), were measured at baseline in plasma and in the erythrocytes membrane. Cognitive status was assessed using the mini mental state examination (MMSE), at baseline and every six months during follow-up. The median follow-up period was of 11,5 months.
Compared to participants with minor neurocognitive disorders (MMSE≥24), participants with major neurocognitive disorders (NCD) had lower plasmatic concentrations of EPA and DHA (p<0.05) at baseline. Erythrocyte AA and DHA concentrations were significantly lower in patients with cognitive decline (defined as a ≥2 points loss of MMSE per year), while no difference in plasmatic concentrations was observed.
Our study suggests that ω-3 PUFA plasma concentrations (mainly EPA and DHA) could be associated with cognitive status in older people. Moreover, in this exploratory study, lower erythrocyte PUFA concentrations (AA and DHA) were associated with accelerated decline and could be proposed as a surrogate marker for prediction of cognitive decline.
Key wordsDementia neurocognitive disorders biomarkers fatty acids erythrocytes membrane
Activities of daily living
Instrumental activities of daily living
mild cognitive impairment
mini mental state examination
Magnetic resonance imaging
poly unsaturated fatty acids.
- 1.Scarmeas N, Stern Y, Tang M-X, Mayeux R, Luchsinger JA. Mediterranean diet and risk for Alzheimer’s disease. 2006; 59(6):912–21.Google Scholar
- 2.Cederholm T, Salem N, Palmblad J. ω-3. Fatty Acids in the Prevention of Cognitive Decline in Humans 2013;123.4(6):672–6. /PMC3823515/Google Scholar
- 4.Fougère B, de Souto Barreto P, Goisser S, Soriano G, Guyonnet S, Andrieu S, et al. Red blood cell membrane omega-3 fatty acid levels and physical performance: Crosssectional data from the MAPT study. Clin Nutr Edinb Scotl. 2017 Apr 12Google Scholar
- 8.Samieri C, Féart C, Letenneur L, Dartigues J-F, Pérès K, Auriacombe S, et al. Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk. Am J Clin Nutr [Internet]. 2008 Sep 1 [cited 2014 Jan 24];88(3):714–21. Available from: http://ajcn.nutrition.org/content/88/3/714CrossRefPubMedGoogle Scholar
- 9.Whalley LJ, Deary IJ, Starr JM, Wahle KW, Rance KA, Bourne VJ, et al. n–3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood. Am J Clin Nutr [Internet]. 2008 Feb 1 [cited 2014 Jan 24];87(2):449–54. Available from: http://ajcn.nutrition.org/content/87/2/449CrossRefPubMedGoogle Scholar
- 12.Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, et al. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer’s Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis JAD. 2015; 48(3):805–12.CrossRefPubMedGoogle Scholar
- 13.MacLean CH, Issa AM, Newberry SJ, Mojica WA, Morton SC, Garland RH, et al. Effects of Omega-3 Fatty Acids on Cognitive Function with Aging, Dementia, and Neurological Diseases. Agency for Healthcare Research and Quality (US); 2005.Google Scholar
- 17.American Psychiatric Association. Diagnostic and statistical manual of mental disorders. (5th ed). Washington, DC; 2013.Google Scholar
- 19.Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc;2011;7(3):270–9./PMC3312027/CrossRefGoogle Scholar
- 20.Portet F, Ousset PJ, Visser PJ, Frisoni GB, Nobili F, Scheltens P, et al. Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease. J Neurol Neurosurg Psychiatry:2006;714–8./PMC2077456/Google Scholar
- 24.Yuan L, Zhen J, Ma W, Cai C, Huang X, Xiao R. The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults. Nutrients. 2016;8(7).Google Scholar
- 26.Simultaneous quantitative profiling of 20 isoprostanoids from omega-3 and omega-6 polyunsaturated fatty acids by LC-MS/MS in various biological samples. [Internet]. [cited 2016 Jul 5]. Available from: http://ac.els-cdn.com.docelec.univ-lyon1.fr/S0003267016303415/1-s2.0-S0003267016303415-main.pdf?_tid=426f82f0-42f6-11e6-ab86-00000aacb35e&acdnat=1467753792_c4a9baaf74d3fa7a80f2dc5eb60602c6Google Scholar
- 27.R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.; 2014.Google Scholar
- 36.Yurko-Mauro K, Alexander DD, Van Elswyk ME. Docosahexaenoic Acid and Adult Memory: A Systematic Review and Meta-Analysis. PLoS ONE [Internet]. 2015 Mar 18 [cited 2016 Aug 7];10(3). Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364972/Google Scholar
- 38.D’Ascoli TA, Mursu J, Voutilainen S, Kauhanen J, Tuomainen T-P, Virtanen JK. Association between serum long-chain omega-3 polyunsaturated fatty acids and cognitive performance in elderly men and women: The Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr. 2016 Aug;70(8):970–5.CrossRefPubMedGoogle Scholar
- 42.Heude B, Ducimetière P, Berr C. Cognitive decline and fatty acid composition of erythrocyte membranes—The EVA Study. Am J Clin Nutr:2003;803–8.Google Scholar
- 43.Hooper C, De Souto Barreto P, Payoux P, Salabert AS, Guyonnet S, Andrieu S, et al. Cross-sectional associations of cortical β-amyloid with erythrocyte membrane longchain polyunsaturated fatty acids in older adults with subjective memory complaints. J Neurochem. 2017 Aug;142(4):589–96.CrossRefPubMedGoogle Scholar
- 43.Lopes da Silva S, Vellas B, Elemans S, Luchsinger J, Kamphuis P, Yaffe K, et al. Plasma nutrient status of patients with Alzheimer’s disease: Systematic review and meta-analysis. Alzheimers Dement, 2013; S1552526013024643Google Scholar