The journal of nutrition, health & aging

, Volume 22, Issue 4, pp 513–518 | Cite as

Age and IQ Explained Working Memory Performance in a RCT with Fatty Fish in a Group of Forensic Inpatients

  • Anita L. Hansen
  • G. Ambroziak
  • D. Thornton
  • L. Dahl
  • B. Grung



To investigate the effect of a long-term fatty fish intervention on a pure cognitive mechanism important for self-regulation and mental health, i.e. working memory (WM), controlling for age and IQ.


A randomized controlled trial.


A forensic facility.


Eighty-four young to middle aged male forensic inpatients with psychiatric disorders.


Consumption of farmed salmon or control meal (meat) three times a week during 23 weeks.


Performance on WM tasks, both accuracy and mean reaction time, were recorded pre and post intervention.


Performance on a cognitive functioning tasks taxing WM seemed to be explained by age and IQ.


Fatty fish consumption did not improve WM performance in a group of young to middle aged adults with mental health problems, as less impressionable factors such as aging and intelligence seemed to be the key components. The present study improves the knowledge concerning the interaction among nutrition, health and the aging process.

Key words

Fatty fish consumption working memory age IQ 


  1. 1.
    Dangour AD, Allen E, Elbourne D, Fletcher A, Richards M, Uauy R. Fish consumption and cognitive function among older people in the UK: baseline data from the OPAL study. J Nutr Health Aging 2009;13:198–202.CrossRefPubMedGoogle Scholar
  2. 2.
    Alexander J, Frøyland L, Hemre GI, Jacobsen BK, Lund E, Meltzer HM, Skåre JU. A Comprehensive Assessment of Fish and Other Seafood in the Norwegian Diet; Norwegian Scientific Committee for Food Safety: Oslo, Norway, 2007.Google Scholar
  3. 3.
    Gijselaers HJM, Barberà E, Kirschner PA, de Groot RHM. Physical activity, sleep, and nutrition do not predict cognitive performance in young and middle-aged adults. Front Psychol 2016;7:642. doi:10.3389/fpsyg.2016.00642.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Baddeley A. Working memory: Looking back and looking forward. Nat Rev Neurosci 2003;4:829–839.CrossRefPubMedGoogle Scholar
  5. 5.
    Uekermann J, Channon S, Lehmkämper C, Abdel-Hamid M, Vollmoeller W, Daum. Executive function, mentalizing and humor in major depression. JINS 2008;14:55–62.PubMedGoogle Scholar
  6. 6.
    De Luca CR, Wood SJ, Anderson V, Buchanan JA, Proffitt TM, Mahony K, Pantelis C. Normative data from the cantab. I: Development of executive function over the lifespan. J Clin Exp Neuropsyc 2003;25:242–254.Google Scholar
  7. 7.
    Sullivan JR, Riccio CA, Castillo CL. Concurrent validity of the tower tasks as measures of executive function in adults: a meta-analysis. Appl Neuropsychol 2009;16:62–75.CrossRefPubMedGoogle Scholar
  8. 8.
    Hansen AL, Dahl L, Olson G, Thornton D, Grung B, Thayer JF. A long-term fatty fish intervention improved executive function in inpatients with antisocial traits and a history of alcohol and drug abuse. Scand J Psychol 2015;56:467–474. doi: 10.1111/ sjop.12229.CrossRefPubMedGoogle Scholar
  9. 9.
    Arffa S. The relationship of intelligence to executive function and non-executive function measure in a sample of average, above average, and gifted youth. Arch Clin Neuropsychol 2007;22:969–978.CrossRefPubMedGoogle Scholar
  10. 10.
    Blokland GAM, McMahon KL, Hoffman J, Zhu G, Meredith M, Martin NG, Thompson PM, de Zubicaray GI, Wright MJ. Quantifying the heritability of taskrelated brain activation and performance during the N-back working memory task: A twin fMRI study. Biol Psychol 2008;79:70–79.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Wechsler D. Wechsler Adult Intelligence Scale–Fourth Edition. Pearson, San Antonio, 2008Google Scholar
  12. 12.
    Hare RD. The Hare Psychopathy Checklist-Revised. Multi-Health Systems, Toronto, 1991Google Scholar
  13. 13.
    Alshurafa M, Briel M, Akl M, Haines T, Moayyedi P, Gentles SJ, Rios L, Tran C, Bhatnagar N, Lamontagne F, Walter S, Guyatt GH. Inconsistent Definitions for Intention-To-Treat in Relation to Missing Outcome Data: Systematic Review of the Methods Literature. PLOS one 2012;7:e49163 DOI: 10.1371/journal.pone.0049163CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Owen AM, McMillan KM, Laird AR, Bullmore E. N-back working memory paradigm: A Meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 2005;25:46–59.CrossRefPubMedGoogle Scholar
  15. 15.
    Shimamura AP. The role of the prefrontal cortex in dynamic filtering. Psychophysiology 2000;28:207–218.Google Scholar
  16. 16.
    Ratcliff R. Methods for dealing with reaction time outliers. Psychol Bull 1993;114:510–532.CrossRefPubMedGoogle Scholar
  17. 17.
    Hansen AL, Dahl L, Olson G, Thornton D, Graff IE, Frøyland L, Thayer JF, Pallesen S. Fish consumption, sleep, daily functioning and heart rate variability. J Clin Sleep Med 2014;10:567–575.PubMedPubMedCentralGoogle Scholar
  18. 18.
    Harris WS. The omega-3 index as a risk factor for coronary heart disease. Am J Clin Nutr; 2008;87:1997S–2002SCrossRefPubMedGoogle Scholar
  19. 19.
    Van den Berg M, Birnbaum L, Denison M, De Vito M, Farland W, Feeley, M, Feeley H, Feeley H, Feeley A, Haws L, et al. The 2005 World Health Organization Reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006;93:223–241.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Chen YN, Mitra S, Schlaghecken F. Sub-processes of working memory in the N-back task: An investigation using ERPs. Clin Neurophysiol 2008;119:1546–1559.CrossRefPubMedGoogle Scholar
  21. 21.
    Best JR, Miller PH, Jones LL. Executive functions after age 5: Changes and correlates. Dev Rev 2009;29:180–200.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Lee DM, Tajar A, Ulubaev A, Pendelton N, O’Neill TW, O’Connor DB, Bartfai G, Boonen S, Bouillon R, Cassanueva FF, et al. Association between 25-hydroxyvitamin D levels and cognitive performance in middle aged and older European men. J Neurol Neurosurg Psychiatry 2009;80:722–729.CrossRefPubMedGoogle Scholar
  23. 23.
    Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, Legre R, Khrestchatisky M, Decherchi P, Feron F. Cholecalciferol (Vitamin D) improves myelination and recovery after nerve injury. PLOS one 2013;8:e65034CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Weiser MJ, Butt CM, Mohajeri H. Docosahexaenoic Acid and Cognition throughout the Lifespan Nutrients 2016;8:99. doi: 10.3390/nu8020099PubMedGoogle Scholar
  25. 25.
    Stonehouse W., Conlon CA, Podd J, Hill SR, Minihane AM, Haskell C, Kennedy D. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. Am J Clin Nutr, 2013;97:1134–1143CrossRefPubMedGoogle Scholar
  26. 26.
    Sleely CJ, Smith CT, MacDonald KJ, Beninger RJ. Ventral prefrontal theta activity during rapid eye movement sleep is associated with improved decision-making in the Iowa Gambling Task. Behav Neurosci 2016;130:271–280.CrossRefGoogle Scholar
  27. 27.
    Thayer JF, Hansen AL, Saus ER, Johnsen BH. Heart rate variability, prefrontal neural function, and cognitive performance: The Neurovisceral Integration Perspective. Ann Behav Med 2009;37:141–153.CrossRefPubMedGoogle Scholar
  28. 28.
    Thayer JF, Åhs F, Fredrikson M, Sollers JJ, Wager RD. A meta-analysis of heart rate variability and neuroimagine studies: Implications for heart rate variability as a maker of stress and health. Neurosci Biobehav Rev 2012;36:747–756.CrossRefPubMedGoogle Scholar

Copyright information

© Serdi and Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  • Anita L. Hansen
    • 1
    • 2
  • G. Ambroziak
    • 3
  • D. Thornton
    • 2
    • 4
  • L. Dahl
    • 5
  • B. Grung
    • 6
  1. 1.Department of Clinical PsychologyUniversity of BergenBergenNorway
  2. 2.Centre for Research and Education in Forensic PsychiatryHaukeland University HospitalBergenNorway
  3. 3.Sand Ridge Secure Treatment Center (SRSTC)MaustonUSA
  4. 4.FASTR, LLC 1213 N.MadisonUSA
  5. 5.National Institute of Nutrition and Seafood Research (NIFES)BergenNorway
  6. 6.Department of ChemistryUniversity of BergenBergenNorway

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