The journal of nutrition, health & aging

, Volume 22, Issue 4, pp 471–475 | Cite as

Insulin Resistance is Associated with Chronic Laryngitis in Korean Women

Article

Abstract

Objectives

The aim of this study was to investigate the association between chronic laryngitis (CL) and insulin resistance (IR) in South Korea using data from the 2010 Korea National Health and Nutrition Examination Surveys (KNHANES).

Design, setting and participants

Cross-sectional data of 4,261 adults who completed KNHANES were analyzed. CL was considered when participants experienced a voice change and demonstrated flexible laryngoscopic findings of diffuse laryngeal inflammation. All participants were assessed for IR using the homeostasis model assessment of insulin resistance (HOMA-IR).

Results

Among the Korean population older than 19 years, the prevalence of chronic laryngitis was 3.8±0.7%. Univariate analysis demonstrated that CL was significantly associated with smoking and systolic and diastolic blood pressure in men and with age, diastolic blood pressure, HDL cholesterol, insulin, and HOMA-IR in women. Multiple regression analysis demonstrated that the mean value of HOMA-IR was significantly associated with CL in women only. In addition, CL was more prevalent in the highest compared with the lowest HOMA-IR quartile (OR [95% CI]: 2.268 [1.053-4.884] after adjusting for age, OR [95% CI]: 2.235 [1.040-6.181] after adjusting for confounding factors of age, body mass index, smoking status, alcohol intake, regular exercise, education, and income).

Conclusions

These findings indicate that IR characterized by HOMA-IR is significantly associated with CL in Korean women only. Our results suggest that HOMA-IR could be an early predictive factor of increased risk of CL in Korean women.

Key words

Laryngitis insulin resistance epidemiology Republic of Korea 

References

  1. 1.
    Hammer HF. Reflux-associated laryngitis and laryngopharyngeal reflux: a gastroenterologist’s point of view. Digestive diseases (Basel, Switzerland). 2009;27:14–17.CrossRefGoogle Scholar
  2. 2.
    Vaezi MF. Laryngeal manifestations of gastroesophageal reflux disease. Current gastroenterology reports. 2008;10:271–277.CrossRefPubMedGoogle Scholar
  3. 3.
    Stein DJ, Noordzij JP. Incidence of chronic laryngitis. The Annals of otology, rhinology, and laryngology. 2013;122:771–774.CrossRefPubMedGoogle Scholar
  4. 4.
    Choi JH, Park S, Shin YH, Kim MY, Lee YJ. Sex differences in the relationship between metabolic syndrome and pulmonary function: the 2007 Korean National Health and Nutrition Examination Survey. Endocr J. 2011;58:459–465.CrossRefPubMedGoogle Scholar
  5. 5.
    Lee CM, Huxley RR, Woodward M, Zimmet P, Shaw J, Cho NH, et al., Comparisons of metabolic syndrome definitions in four populations of the Asia-Pacific region. Metab Syndr Relat Disord. 2008;6:37–46.CrossRefPubMedGoogle Scholar
  6. 6.
    Regitz-Zagrosek V1, Lehmkuhl E, Weickert MO. Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol. 2006;95:136–147.CrossRefPubMedGoogle Scholar
  7. 7.
    Ricci G, Pirillo I, Tomassoni D, Sirignano A, Grappasonni I. Metabolic syndrome, hypertension, and nervous system injury: Epidemiological correlates. Clin Exp Hypertens. 2017;39:8–16.CrossRefPubMedGoogle Scholar
  8. 8.
    Schwartz MW, Porte D, Jr. Diabetes, obesity, and the brain. Science (New York, NY). 2005;307:375–379.CrossRefGoogle Scholar
  9. 9.
    Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes care. 2004;27:813–823.CrossRefPubMedGoogle Scholar
  10. 10.
    Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607.CrossRefPubMedGoogle Scholar
  11. 11.
    Kweon S, Kim Y, Jang MJ, Kim Y, Kim K, Choi S, et al. Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). International journal of epidemiology. 2014;43:69–77.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Lim SG, Han K, Kim HA, Pyo SW, Cho YS, Kim KS, et al. Association between insulin resistance and periodontitis in Korean adults. Journal of clinical periodontology. 2014;41:121–130.CrossRefPubMedGoogle Scholar
  13. 13.
    Wallace TM, Matthews DR. The assessment of insulin resistance in man. Diabetic medicine: a journal of the British Diabetic Association. 2002;19:527–34.CrossRefGoogle Scholar
  14. 14.
    Tan GS, Wong TY, Fong CW, Aung T. Diabetes, metabolic abnormalities, and glaucoma. Archives of ophthalmology (Chicago, Ill: 1960). 2009;127:1354–1361.CrossRefGoogle Scholar
  15. 15.
    Kim KM, Cho YK, Bae SJ, Kim DS, Shim KN, Kim JH, et al. Prevalence of gastroesophageal reflux disease in Korea and associated health-care utilization: a national population-based study. Journal of gastroenterology and hepatology. 2012;27:741–745.CrossRefPubMedGoogle Scholar
  16. 16.
    Park JH, Lee DH, Kim JY, Park SY, Yoon H, Park YS, et al. Gastroesophageal reflux disease with laryngopharyngeal manifestation in Korea. Hepato-gastroenterology. 2012;59:2527–2529.PubMedGoogle Scholar
  17. 17.
    Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngology—head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2000;123:385–388.CrossRefGoogle Scholar
  18. 18.
    Beaver ME, Stasney CR, Weitzel E, Stewart MG, Donovan DT, Parke RB Jr, et al. Diagnosis of laryngopharyngeal reflux disease with digital imaging. Otolaryngology—head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2003;128:103–108.CrossRefGoogle Scholar
  19. 19.
    Dworkin JP. Laryngitis: types, causes, and treatments. Otolaryngologic clinics of North America. 2008;41:419–436.CrossRefPubMedGoogle Scholar
  20. 20.
    Ierardi E, Rosania R, Zotti M, Principe S, Laonigro G, Giorgio F, et al. Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries. World journal of gastrointestinal pathophysiology. 2010;1:91–96.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. The American journal of gastroenterology. 2005;100:1243–1250.CrossRefPubMedGoogle Scholar
  22. 22.
    Kallel L, Bibani N, Fekih M, Matri S, Karoui S, Mustapha NB, et al. Metabolic syndrome is associated with gastroesophageal reflux disease based on a 24-hour ambulatory pH monitoring. Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus / ISDE. 2011;24:153–159.CrossRefGoogle Scholar
  23. 23.
    Niigaki M, Adachi K, Hirakawa K, Furuta K, Kinoshita Y. Association between metabolic syndrome and prevalence of gastroesophageal reflux disease in a health screening facility in Japan. Journal of gastroenterology. 2013;48:463–472.CrossRefPubMedGoogle Scholar
  24. 24.
    Watanabe S, Hojo M, Nagahara A. Metabolic syndrome and gastrointestinal diseases. Journal of gastroenterology. 2007;42:267–274.CrossRefPubMedGoogle Scholar
  25. 25.
    Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419.CrossRefPubMedGoogle Scholar
  26. 26.
    Joo YH, Han KD, Lee SS. Association between Obesity and Chronic Laryngitis in Women-Data from the Korea National Health and Nutrition Examination Survey. Obesity facts. 2015;8:252–60.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Serdi and Springer-Verlag France SAS, part of Springer Nature 2017

Authors and Affiliations

  • J.-H. Cho
    • 1
  • S.-S. Lee
    • 2
  • K.-D. Han
    • 3
  • Young-Hoon Joo
    • 4
    • 5
  1. 1.Department of Otolaryngology-Head and Neck SurgerySt. Vincent’s hospitalSuwonKorea
  2. 2.Department of EndocrinologySeoulKorea
  3. 3.Department of Biostatistics, College of MedicineThe Catholic University of KoreaSeoulKorea
  4. 4.Department of Otolaryngology-Head and Neck SurgerySeoulKorea
  5. 5.Department of Otolaryngology, Head and Neck Surgery, Bucheon St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaBucheon, Kyounggi-doRepublic of Korea

Personalised recommendations