Abstract
Objectives
Although osteoarthritis (OA) is a common condition in older adults, the role of OA in increasing cardiovascular disease (CVD) incidence is still debated. The aim of this study was to investigate the association between OA and the onset of CVD in a large database of American adults.
Design
Longitudinal.
Setting
Community-dwelling.
Participants
People with OA or at high risk of OA.
Measurements
Osteoarthritis was defined as the presence of OA of the hand, knee, hip, back/neck or of other sites. CVD was defined as self-reported presence of heart attack, heart failure, stroke and other cerebral atherosclerotic conditions, and peripheral artery disease.
Results
A total 4,265 persons without CVD (mean age=60.8 years, females=59.2%) at baseline were analyzed (1,775 with OA versus 2,490 without). Over a mean of 8.2 years, according to an adjusted Cox’s regression analysis for 11 potential baseline confounders, study participants with OA of any joint had a significantly higher risk of developing CVD compared to those without OA (Hazard ratio (HR): =1.27; 95% CI: 1.03-1.56). The presence of hand OA was associated with a higher risk of developing CVD (HR=1.31; 95%CI: 1.01-1.68) with respect to those who had no OA. Knee, hip and back/neck OA did not, instead, increase the risk of developing CVD. The association between OA and CVD was significant in the women, but not in the men.
Conclusions
OA, in particular, when it affects the hand and in women, was associated with a higher risk of developing CVD.
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References
Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013;380:2163–96 doi:http://dx.doi.org/10.1016/S0140-6736(12)61729-2
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL, Laslett LL, Jones G, Cicuttini F, Osborne R, Vos T, Buchbinder R, Woolf A, March L. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Annals of the rheumatic diseases 2014;73:1323–30 doi:10.1136/annrheumdis-2013-204763
Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC et al. Osteoarthritis (ESCEO). Seminars in arthritis and rheumatism 2013;43:303–13 doi:10.1016/j.semarthrit.2013.07.003
Hunter DJ, Felson DT Osteoarthritis. BMJ 2006;332:639–42 doi:10.1136/bmj.332.7542.639
Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis and rheumatism 1998;41:778–99
Veronese N, Stubbs B, Solmi M, Smith TO, Noale M, Cooper C, Maggi S. Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative. Age and ageing, 2016 doi:10.1093/ageing/afw216
Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology 2005;44:7–16 doi:10.1093/rheumatology/keh344
Hardingham T. Extracellular matrix and pathogenic mechanisms in osteoarthritis 2008;10:30–6. doi:10.1007/s11926-008-0006-9
Ju H, Dixon IM. Extracellular matrix and cardiovascular diseases. Can J Cardiol 1996;12:1259–67
Hall AJ, Stubbs B, Mamas MA, Myint PK, Smith TO. Association between osteoarthritis and cardiovascular disease: Systematic review and metaanalysis. European journal of preventive cardiology 2016;23:938–46 doi:10.1177/2047487315610663
Nüesch E, Dieppe P, Reichenbach S, Williams S, Iff S, Jüni P. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ 2011;342:d1165–d65 doi:10.1136/bmj.d1165
Veronese N, Trevisan C, De Rui M, Bolzetta F, Maggi S, Zambon S, Musacchio E, Sartori L, Perissinotto E, Crepaldi G, Manzato E, Sergi G. Association of Osteoarthritis With Increased Risk of Cardiovascular Diseases in the Elderly: Findings From the Progetto Veneto Anziano Study Cohort (in eng). Arthritis & rheumatology (Hoboken, NJ) 2016;68:1136–44 doi:10.1002/art.39564
Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ open 2013;3:10.1136/bmjopen-2013-002624 doi:10.1136/bmjopen-2013-002624
Hoeven TA, Leening MJG, Bindels PJ, Castaño-Betancourt M, van Meurs JB et al. Disability and not osteoarthritis predicts cardiovascular disease: a prospective population-based cohort study. Annals of the rheumatic diseases 2014;74:S46–S46 doi:10.1136/annrheumdis-2013-204388
Washburn RA, McAuley E, Katula J, Mihalko SL, Boileau RA. The physical activity scale for the elderly (PASE): evidence for validity. Journal of clinical epidemiology 1999;52:643–51
Katz JN, Chang LC, Sangha O, Fossel AH, Bates DW. Can comorbidity be measured by questionnaire rather than medical record review? Medical care 1996;34:73–84
Fernandes GS, Valdes AM. Cardiovascular Disease and Osteoarthritis: Common Pathways and Patient Outcomes. European Journal of Clinical Investigation 2015;445:405–14 doi:10.1111/eci.12413
Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, Egger M, Jüni P. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ 2011;342:c7086–c86 doi:10.1136/bmj.c7086
Sergi G, Veronese N, Fontana L, De Rui M, Bolzetta F, Zambon S, Corti M-C, Baggio G, Toffanello ED, Crepaldi G, Perissinotto E, Manzato E. Pre-frailty and risk of cardiovascular disease in elderly men and women: the pro.v.a. study (in eng). Journal of the American College of Cardiology 2015;65:976–83 doi:10.1016/j. jacc.2014.12.040
Rao TP, Kühl M. An updated overview on wnt signaling pathways: A prelude for more 2010;106:1798–806. doi:10.1161/CIRCRESAHA.110.219840
Veronese N, Cereda E, Maggi S, Luchini C, Solmi M, Smith T, Denkinger M, Hurley M, Thompson T, Manzato E, Sergi G, Stubbs B. Mortality: A Prospective Cohort Study and Systematic Review with Meta-analysis (in English). Seminars in Arthritis and Rheumatism 2016;46:160–7. doi:10.1016/j. semarthrit.2016.04.002
Jonsson H, Helgadottir GP, Aspelund T, Eiriksdottir G, Sigurdsson S, Ingvarsson T, Harris TB, Launer L, Gudnason V. Hand osteoarthritis in older women is associated with carotid and coronary atherosclerosis: the AGES Reykjavik study. Annals of the rheumatic diseases 2009;68:1696–700 doi:10.1136/ard.2008.096289
Watt FE. Hand osteoarthritis, menopause and menopausal hormone therapy. Maturitas 2015;83:13–18 doi:10.1016/j.maturitas.2015.09.007
Bay-Jensen AC, Slagboom E, Chen-An P, Alexandersen P, Qvist P, Christiansen C, Meulenbelt I, Karsdal Ma. Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause 2013;20:578–86 doi:10.1097/GME.0b013e3182745993
Kluzek S, Sanchez-Santos MT, Leyland KM, Judge A, Spector TD, Hart D, Cooper C, Newton J, Arden NK. Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women. Annals of the rheumatic diseases:annrheumdis-2015-208056 doi:10.1136/annrheumdis-2015-208056
Hoeven TA, Kavousi M, Ikram MA, van Meurs JB, Bindels PJ, Hofman A, Franco OH, Bierma-Zeinstra SM. Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. Rheumatology 2015;54:1692–98 doi:10.1093/rheumatology/kev106
Smiley Da, Khalil Ra. Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Current medicinal chemistry 2009;16:1863–87 doi:10.2174/092986709788186093
Poulain-Godefroy O, Le Bacquer O, Plancq P, Lecoeur C, Pattou F, Frühbeck G, Froguel P (2010) Inflammatory role of Toll-like receptors in human and murine adipose tissue. Mediators of inflammation 2010:823486–86 doi:10.1155/2010/823486
Akira S, Takeda K. Toll-like receptor signalling. Nature reviews Immunology 2004;4:499–511 doi:10.1038/nri1391
Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, Jones DW, Kurtz T, Sheps SG, Roccella EJ. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Cou. Hypertension 2005;45:142–61 doi:10.1161/01.HYP.0000150859.47929.8e
Libby P. Inflammation and cardiovascular disease mechanisms. The American journal of clinical nutrition 2006;83:456S–60S
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Veronese, N., Stubbs, B., Solmi, M. et al. Osteoarthritis Increases the Risk of Cardiovascular Disease: Data from the Osteoarthritis Initiative. J Nutr Health Aging 22, 371–376 (2018). https://doi.org/10.1007/s12603-017-0941-0
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DOI: https://doi.org/10.1007/s12603-017-0941-0