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The journal of nutrition, health & aging

, Volume 21, Issue 10, pp 1133–1141 | Cite as

Soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not improve muscle functional property restoration

  • J. Verney
  • V. Martin
  • S. Ratel
  • V. Chavanelle
  • M. Bargetto
  • M. Etienne
  • E. Chaplais
  • P. Le Ruyet
  • C. Bonhomme
  • L. Combaret
  • C. Guillet
  • N. Boisseau
  • P. Sirvent
  • Dominique Dardevet
Article

Abstract

Objectives

Effect of 3 different dairy protein sources on the recovery of muscle function after limb immobilization in old rats.

Design

Longitudinal animal study.

Setting

Institut National de la Recherche Agronomique (INRA). The study took part in a laboratory setting.

Intervention

Old rats were subjected to unilateral hindlimb immobilization for 8 days and then allowed to recover with 3 different dietary proteins: casein, soluble milk proteins or whey proteins for 49 days.

Measurements

Body weight, muscle mass, muscle fibre size, isometric, isokinetic torque, muscle fatigability and muscle oxidative status were measured before and at the end of the immobilization period and during the recovery period i.e 7, 21, 35 and 49 days post immobilization.

Results

In contrast to the casein diet, soluble milk proteins and whey proteins were efficient to favor muscle mass recovery after cast immobilization during aging. By contrast, none of the 3 diary proteins was able to improve muscle strength, power and fatigability showing a discrepancy between the recovery of muscle mass and function. However, the soluble milk proteins allowed a better oxidative capacity in skeletal muscle during the rehabilitation period.

Conclusion

Whey proteins and soluble milk proteins improve muscle mass recovery after immobilization-induced muscle atrophy in old rats but do not allow muscle functional property restoration.

Key words

Aging immobilization muscle mass recovery muscle function whey proteins 

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Copyright information

© Serdi and Springer-Verlag France 2017

Authors and Affiliations

  • J. Verney
    • 1
  • V. Martin
    • 1
  • S. Ratel
    • 1
  • V. Chavanelle
    • 1
  • M. Bargetto
    • 1
  • M. Etienne
    • 1
  • E. Chaplais
    • 1
  • P. Le Ruyet
    • 2
  • C. Bonhomme
    • 2
  • L. Combaret
    • 3
  • C. Guillet
    • 3
    • 4
  • N. Boisseau
    • 1
  • P. Sirvent
    • 1
  • Dominique Dardevet
    • 3
  1. 1.Clermont Université, Université Blaise Pascal, EA 3533, Laboratoire des Adaptations Métaboliques à l’Exercice en Conditions Physiologiques et PathologiquesCRNH AuvergneClermont FerrandFrance
  2. 2.Lactalis Recherche et DéveloppementLactalis Nutrition SantéTorcéFrance
  3. 3.INRA, Unité de Nutrition Humaine (UNH, UMR 1019)CRNH AuvergneAuvergneFrance
  4. 4.Clermont Université, Université d’AuvergneClermont-FerrandFrance

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