Frailty in relation to the risk of Alzheimer’s disease, dementia, and death in older Chinese adults: A seven-year prospective study
- 321 Downloads
To explore the relationship of general health decline assessed by frailty and risk of dementia and Alzheimer’s disease (AD).
A seven-year prospective cohort study.
Secondary analysis of data from the Beijing Longitudinal Study on Aging.
Urban and rural communitydwelling people aged 60 and older at baseline.
Frailty was quantified using the deficit accumulation-based frailty index (FI), constructed from 40 health deficits at baseline. Dementia was diagnosed by DSM-IIIR. AD and vascular dementia (VaD) were diagnosed by NINCDS-ADRDA and NINDS-AIREN. The relationships between frailty and the risk of dementia, AD and death were evaluated through multivariable models.
Of 2788 participants at baseline (1997), 171 (11.1%) reported a history of dementia. In seven years, 351 people developed dementia (13%: 223 AD and 128 other types of dementia) and 813 died (29%). After adjustment for age, sex, education, and baseline cognition, baseline frailty status significantly associated with Alzheimer’s disease and dementia and death. For each deficit accumulated, the odds ratio of death increased by 5.7%, and the odds ratio of dementia increased by 2.9% (p < 0.001).
Frailty was associated with Alzheimer’s disease and dementia over a seven years period. Frailty index might facilitate the identification of older adults at high risk of dementia for the application of the most effective, targeted prevention strategies.
Key wordsAgeing frailty frailty index (FI) Alzheimer’s disease (AD) dementia
- 4.Zhang ZX, Zahner GE, Roman GC, et al. Socio-demographic variation of dementia subtypes in china: Methodology and results of a prevalence study in Beijing, Chengdu, Shanghai, and Xian. Neuroepidemiology 2006;177–187.Google Scholar
- 6.Berti V, Murray J, Davies M, Spector N, Tsui WH, Li Y, Williams S, Pirraglia E, Vallabhajosula S, McHugh P, Pupi A, de Leon MJ, Mosconi L. Nutrient patterns and brain biomarkers of Alzheimer’s disease in cognitively normal individuals. J Nutr Health Aging. 2015;19(4): 413–423.CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Handing EP, Small BJ, Reynolds SL, Kumar NB. Impact of dietary factors and inflammation on cognition among older adults. J Prev Alz Dis. 2015; 2(4):220–226.Google Scholar
- 9.Willey JZ, Gardener H, Caunca MR et al. Leisure-time physical activity associates with cognitive decline: The Northern Manhattan Study. Neurology, 2016. pii: 10.1212/WNL.0000000000002582. [Epub ahead of print]Google Scholar
- 10.Fried LP, Tangen CM, Walston J et al. Frailty in older adults:evidence for a phenotype. Journal of Gerontology:Medical Sciences 2001;56A:M146–M156.Google Scholar
- 21.Kelaiditi E, Andrieu S, Cantet C, Vellas B, Cesari M; ICTUS/DSA Group. Frailty Index and Incident Mortality, Hospitalization,and Institutionalization in Alzheimer’s Disease: Data From the ICTUS Study. J Gerontol A Biol Sci Med Sci, 2015. pii: glv137. [Epub ahead of print].Google Scholar