Tea consumption reduces the incidence of neurocognitive disorders: Findings from the Singapore longitudinal aging study

Abstract

Objectives

To examine the relationships between tea consumption habits and incident neurocognitive disorders (NCD) and explore potential effect modification by gender and the apolipoprotein E (APOE) genotype.

Design

Population-based longitudinal study.

Setting

The Singapore Longitudinal Aging Study (SLAS).

Participants

957 community-living Chinese elderly who were cognitively intact at baseline.

Measurements

We collected tea consumption information at baseline from 2003 to 2005 and ascertained incident cases of neurocognitive disorders (NCD) from 2006 to 2010. Odds ratio (OR) of association were calculated in logistic regression models that adjusted for potential confounders.

Results

A total of 72 incident NCD cases were identified from the cohort. Tea intake was associated with lower risk of incident NCD, independent of other risk factors. Reduced NCD risk was observed for both green tea (OR=0.43) and black/oolong tea (OR=0.53) and appeared to be influenced by the changing of tea consumption habit at follow-up. Using consistent nontea consumers as the reference, only consistent tea consumers had reduced risk of NCD (OR=0.39). Stratified analyses indicated that tea consumption was associated with reduced risk of NCD among females (OR=0.32) and APOE e4 carriers (OR=0.14) but not males and non APOE e4 carriers.

Conclusion

Regular tea consumption was associated with lower risk of neurocognitive disorders among Chinese elderly. Gender and genetic factors could possibly modulate this association.

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References

  1. 1.

    Kuriyama S, Shimazu T, Ohmori K, et al. Green Tea Consumption and Mortality Due to Cardiovascular Disease, Cancer, and All Causes in Japan: The Ohsaki Study. JAMA 2006;296:1255–1265.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    InterAct Consortium Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study. PLoS ONE 2012;7:e36910.

    Article  Google Scholar 

  3. 3.

    Arab L, Liu W, Elashoff D. Green and Black Tea Consumption and Risk of Stroke: A Meta-Analysis. Stroke 2009;40:1786–1792.

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Feng L, Li J, Kua E-H, et al. Association Between Tea Consumption and Depressive Symptoms in Older Chinese Adults. J Am Geriatr Soc 2012;60:2358–2360.

    Article  PubMed  Google Scholar 

  5. 5.

    Feng L, Yan Z, Sun B, et al. Tea consumption and depressive symptoms in older people in rural China. J Am Geriatr Soc 2013;61:1943–7.

    Article  PubMed  Google Scholar 

  6. 6.

    Ruan R, Feng L, Li J, Ng TP, Zeng Y. Tea consumption and mortality in the oldestold Chinese. J Am Geriatr Soc 2013;61:1937–42.

    Article  PubMed  Google Scholar 

  7. 7.

    Bloom DE. 7 Billion and Counting. Science 2011;333:562–569.

    CAS  Article  PubMed  Google Scholar 

  8. 8.

    Petersen RC. Clinical practice. Mild cognitive impairment. N Engl J Med 2011;364:2227–34.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    De Bruin EA, Rowson MJ, Van Buren L, Rycroft JA, Owen GN. Black tea improves attention and self-reported alertness. Appetite 2011;56:235–40.

    Article  PubMed  Google Scholar 

  10. 10.

    Feng L, Ng TP, Kua EH, Preedy VR. Tea and cognitive function of elderly people -evidence from neurobiology and epidemiology. In: Preedy VR, ed. Tea in Health and Disease Prevention. 1 ed. London: Elsevier Inc., 2012:11325–1336.

    Google Scholar 

  11. 11.

    Ehrnhoefer DE, Bieschke J, Boeddrich A, et al. EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol 2008;15:558–566.

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Rezai-Zadeh K, Arendash GW, Hou H, et al. Green tea epigallocatechin-3-gallate (EGCG) reduces [beta]-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Research 2008;1214:177–187.

    CAS  Article  PubMed  Google Scholar 

  13. 13.

    Song J, Xu H, Liu F, Feng L. Tea and Cognitive Health in Late Life: Current Evidence and Future Directions. J Nutr Health Aging 2012;16:31–34.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    Kuriyama S, Hozawa A, Ohmori K, et al. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. Am J Clin Nutr 2006;83:355–61.

    CAS  PubMed  Google Scholar 

  15. 15.

    Feng L, Gwee X, Kua EH, Ng TP. Cognitive function and tea consumption in community dwelling older Chinese in Singapore. J Nutr Health Aging 2010;14:433–8.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Ng TP, Feng L, Niti M, Kua EH, Yap KB. Tea consumption and cognitive impairment and decline in older Chinese adults. Am J Clin Nutr 2008;88:224–31.

    CAS  PubMed  Google Scholar 

  17. 17.

    Nurk E, Refsum H, Drevon CA, et al. Intake of Flavonoid-Rich Wine, Tea, and Chocolate by Elderly Men and Women Is Associated with Better Cognitive Test Performance. J Nutr 2009;139:120–127.

    CAS  Article  PubMed  Google Scholar 

  18. 18.

    Feng L, Li J, Ng TP, Lee TS, Kua EH, Zeng Y. Tea drinking and cognitive function in oldest-old Chinese. J Nutr Health Aging 2012;16:754–758.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  19. 19.

    Arab L, Biggs ML, O’Meara ES, Longstreth WT, Crane PK, Fitzpatrick AL. Gender Differences in Tea, Coffee, and Cognitive Decline in the Elderly: The Cardiovascular Health Study. J Alzheimers Dis 2011;27:553–566.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. 20.

    Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study. J Alzheimers Dis 2009;16:85–91.

    CAS  PubMed  Google Scholar 

  21. 21.

    Noguchi-Shinohara M, Yuki S, Dohmoto C, et al. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS ONE 2014;9:e96013.

    Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Feng L, Chong MS, Lim WS, Ng TP. The Modified Mini-Mental State Examination test: normative data for Singapore Chinese older adults and its performance in detecting early cognitive impairment. Singapore Med J 2012;53:458–62.

    PubMed  Google Scholar 

  23. 23.

    Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993;43:2412–4.

    CAS  Article  PubMed  Google Scholar 

  24. 24.

    Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontology: A Guide to Assessment and Intervention. NY: The Haworth Press, 1986:165–73.

    Google Scholar 

  25. 25.

    Lim PP, Ng LL, Chiam PC, Ong PS, Ngui FT, Sahadevan S. Validation and comparison of three brief depression scales in an elderly Chinese population. Int J Geriatr Psychiatry 2000;15:824–30.

    CAS  Article  PubMed  Google Scholar 

  26. 26.

    Feng L, Li J, Yap KB, Kua EH, Ng TP. Vitamin B-12, apolipoprotein E genotype, and cognitive performance in community-living older adults: evidence of a genemicronutrient interaction. Am J Clin Nutr 2009;89:1263–8.

    CAS  Article  PubMed  Google Scholar 

  27. 27.

    Zeng Y, Chen H, Ni T, et al. GxE Interactions Between FOXO Genotypes and Tea Drinking Significantly Affect Cognitive Disability at Advanced Ages in China. J Gerontol A Biol Sci Med Sci 2014. pii: glu060. [Epub ahead of print]

    Google Scholar 

  28. 28.

    Schmidt A, Hammann F, Wolnerhanssen B, et al. Green tea extract enhances parietofrontal connectivity during working memory processing. Psychopharmacology (Berl) 2014.

    Google Scholar 

  29. 29.

    Panza F, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G. Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review. J Nutr Health Aging. 2015 Mar;19(3):313–28. doi: 10.1007/s12603-014-0563-8.

    CAS  Article  PubMed  Google Scholar 

  30. 30.

    Perez-Jimenez J, Hubert J, Hooper L, et al. Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review. Am J Clin Nutr 2010;92:801–809.

    CAS  Article  PubMed  Google Scholar 

  31. 31.

    Soleas GJ, Yan J, Goldberg DM. Ultrasensitive assay for three polyphenols (catechin, quercetin and resveratrol) and their conjugates in biological fluids utilizing gas chromatography with mass selective detection. J Chromatogr B 2001;757:161–172.

    CAS  Article  Google Scholar 

  32. 32.

    Scheid L, Ellinger S, Alteheld B, et al. Kinetics of l-Theanine Uptake and Metabolism in Healthy Participants Are Comparable after Ingestion of l-Theanine via Capsules and Green Tea. J Nutr 2012;142:2091–2096.

    CAS  Article  PubMed  Google Scholar 

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Correspondence to L. Feng.

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Feng, L., Chong, M.-., Lim, W.-. et al. Tea consumption reduces the incidence of neurocognitive disorders: Findings from the Singapore longitudinal aging study. J Nutr Health Aging 20, 1002–1009 (2016). https://doi.org/10.1007/s12603-016-0687-0

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Key words

  • Tea
  • aging
  • neurocognitive disorders
  • Chinese
  • cohort study