The journal of nutrition, health & aging

, Volume 20, Issue 10, pp 1010–1023 | Cite as

Nutritional interventions that slow the age-associated decline in renal function in a canine geriatric model for elderly humans

  • Jean A. HallEmail author
  • M. Yerramilli
  • E. Obare
  • M. Yerramilli
  • K. S. Panickar
  • G. Bobe
  • D. E. Jewell



To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model.


Randomized block design and cross-sectional study. Setting: Hill’s Pet Nutrition, Inc. dog colony.


Eighty-one geriatric dogs (mean age, 10.4; range, 7.9-14.2 years) and 30 mature-adult dogs (mean age, 5.0; range, 3.3-6.9 years).


Geriatric dogs were fed one of three foods (n = 27 per group) for 6 months: a traditional RPF (control) that was energy dense and mildly protein-restricted, or control food supplemented with increasing amounts of functional food bioactives: fish oil, lipoic acid, fruits and vegetables, and higher quality protein sources [functional foods one (FF1) and two (FF2)]. Geriatric dogs were compared before and after the feeding trial with mature adult dogs.


Renal function was assessed by GFR, LB% was determined by dual energy x-ray absorptiometry, and circulating biomarkers and metabolites were measured in blood.


Before the feeding trial, GFR (+28.2%), LB% (+18.6%), and serum total protein (+10.0%) were higher in mature versus healthy geriatric dogs (all P<0.001). Geriatric dogs consuming all three foods increased (P<0.001) GFR over time; group averages ranged from 13.0–16.9%. Dogs fed the highest supplemented level of bioactives (FF2) had lower (P<0.001) symmetric dimethylarginine (SDMA) concentrations (-14.3%). Feeding functional foods did not alter body weight, but increased (P<0.001) serum protein concentration (+6.7%).


Supplementation with functional food bioactives can temporarily reverse the age-associated decline in renal function and serum total protein.

Key words

Dog glomerular filtration rate lean body percent renal biomarkers symmetric dimethylarginine 



amino acid


alpha-linolenic acid


asymmetric dimethylarginine


Association of Analytical Communities


arachidonic acid


blood urea nitrogen


body weight


chronic kidney disease




docosahexaenoic acid


docospentaenoic acid


eicosapentaenoic acid


functional food one


functional food two


fatty acid


glomerular filtration rate


linoleic acid


lean body percent


least squares mean




polyunsaturated fatty acids


renal-protective foods


symmetric dimethylarginine


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Copyright information

© Serdi and Springer-Verlag France 2016

Authors and Affiliations

  • Jean A. Hall
    • 1
    Email author
  • M. Yerramilli
    • 2
  • E. Obare
    • 2
  • M. Yerramilli
    • 2
  • K. S. Panickar
    • 3
  • G. Bobe
    • 4
    • 5
  • D. E. Jewell
    • 3
  1. 1.Department of Biomedical Sciences, College of Veterinary MedicineOregon State UniversityCorvallisUSA
  2. 2.IDEXX Laboratories, Inc.WestbrookUSA
  3. 3.Pet Nutrition CenterHill’s Pet Nutrition, Inc.TopekaUSA
  4. 4.Department of Animal and Rangeland Sciences, College of Agricultural SciencesOregon State UniversityCorvallisUSA
  5. 5.Linus Pauling InstituteOregon State UniversityCorvallisUSA

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