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Oral submucous fibrosis secondary to iron deficiency anemia: A case report, etiopathogenesis and management

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The journal of nutrition, health & aging


Oral submucous fibrosis (OSMF) is a premalignant condition that has received considerable attention in the recent past because of its chronic debilitating and resistant nature. Over the past decades, dental researchers have reported overwhelming evidence about various etiological factors of OSMF. It has been the subject of controversy ever since Schwartz first described the condition in 1952. Areca nut is considered the primary etiology along with other local irritants like capsaicin, pungent and spicy food, nutritional deficiency, defective iron metabolism, collagen metabolic disorder and genetic predisposition. Association of iron deficiency anemia and OSMF is very sparse in literature. Here, we present a case report of a 58 year old male patient where the patient presented with OSMF where iron deficiency anemia was found to be the main etiological factor.

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  1. More CB, Gupta S, Joshi J, Varma SN. Classification System for Oral Submucous Fibrosis. Journal of Indian Academy of Oral Medicine and Radiology 2012;24(1):24–9.

    Article  Google Scholar 

  2. Pundir S, Saxena S, Aggrawal P. Oral submucous fibrosis a disease with malignant potential - Report of two Cases. J Clin Exp Dent. 2010;2(4):e215–8.

    Article  Google Scholar 

  3. Reddy V, Wanjari PV, Banda NR, Reddy P. Oral Submucous Fibrosis: Correlation of Clinical Grading to various habit factors. International journal of dental clinics 2011:3(1):21–4.

    Article  Google Scholar 

  4. Gupta MK, Mhaske S, Ragavendra R, Imtiyaz. Oral submucous fibrosis - Current Concepts in Etiopathogenesis. People’s Journal of Scientific Research 2008; 1: 39–44

    Google Scholar 

  5. R. Rajendran. Oral submucous fibrosis: etiology, pathogenesis, and future research. Bulletin of the World Health Organization 1994; 72 (6): 985–96.

    Google Scholar 

  6. Kamath VV, Satelur K, Komali Y. Biochemical markers in oral submucous fibrosis: A review and update. Dental Research Journal 2013;10(5):576–84.

    PubMed Central  CAS  PubMed  Google Scholar 

  7. Khan S, Chatra L, Prashanth SK, Veena KM, Rao PK. Pathogenesis of oral submucous fibrosis. Journal of Cancer Research and Therapeutics 2012; 8(2):199–203.

    Article  PubMed  Google Scholar 

  8. Bathi RJ, Rao R, Mutalik S. GST null genotype and antioxidants: Risk indicators for oral pre-cancer and cancer. Indian J Dent Res 2009;20(3):298–303.

    Article  PubMed  Google Scholar 

  9. Karemore TV, Karemore VA. Etiopathogenesis and Treatment Strategies of Oral Submucous Fibrosis. Journal of Indian Academy of Oral Medicine and Radiology, October-December 2011;23(4):598–602.

    Article  Google Scholar 

  10. Chatterjee S. Blood eosinophilia in gutkha chewers. Journal of medical research and practice 2012;1(4):86–8.

    Google Scholar 

  11. Manoharan S, Kolanjiappan K, Suresh K, Panjamurthy K. Lipid peroxidation & antioxidants status in patients with oral squamous cell carcinoma. Indian J Med Res 2005;122:529–34.

    CAS  PubMed  Google Scholar 

  12. 12. Kumar A, Bagewadi A, Keluskar V, Singh M. Efficacy of lycopene in the management of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103(2):207–13.

    Article  PubMed  Google Scholar 

  13. Patekar D, Kheur S, Bagul N, Kulkarni M, Mahalle A, Ingle Y, Dhas V. Antioxidant defence system. Oral & Maxillofacial Pathology Journal 2013;4(1):309–15.

    Google Scholar 

  14. Niranjan A, Tewari SK, Lehri A. Biological activities of Kalmegh (Andrographis paniculata Nees) and its active principles-A review. Indian Journal of Natural Products and Resources 2010;1(2):125–35.

    CAS  Google Scholar 

  15. Anagha A. Rajopadhye1, Anuradha S. Upadhye.In vitro Antioxidant and Hepatoprotective Effect of the Whole Plant of Rungia repens (L.) Nees, Against CCl4 Induced Oxidative Stress in Liver Slice Culture Model. International Journal of Phytomedicine 2011;3:540–8.

    Google Scholar 

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Correspondence to Preeti Tomar Bhattacharya.

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Bhattacharya, P.T., Khaitan, T., Sarkar, S.B. et al. Oral submucous fibrosis secondary to iron deficiency anemia: A case report, etiopathogenesis and management. J Nutr Health Aging 20, 205–208 (2016).

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