The journal of nutrition, health & aging

, Volume 18, Issue 9, pp 820–826 | Cite as

A review of the effects of dietary silicon intake on bone homeostasis and regeneration

  • Luigi Fabrizio RodellaEmail author
  • V. Bonazza
  • M. Labanca
  • C. Lonati
  • R. Rezzani



Increasing evidences suggest that dietary Silicon (Si) intake, is positively correlated with bone homeostasis and regeneration, representing a potential and valid support for the prevention and improvement of bone diseases, like osteoporosis. This review, aims to provide the state of art of the studies performed until today, in order to investigate and clarify the beneficial properties and effects of silicates, on bone metabolism.


We conducted a systematic literature search up to March 2013, using two medical databases (Pubmed and the Cochrane Library), to review the studies about Si consumption and bone metabolism.


We found 45 articles, but 38 were specifically focused on Si studies.


Results showed a positive relationship between dietary Si intake and bone regeneration.

Key words

Dietary silicon intake ortho-silicic acid bone regeneration osteoporosis silica scaffolds 


  1. 1.
    Jugdaohsingh R. Silicon and bone health. J Nutr Health Aging 2007;11:99–110PubMedCentralPubMedGoogle Scholar
  2. 2.
    Casey TR, Bamforth CW. Silicon in beer and brewing. J Sci Food Agric 2010;90:784–788PubMedGoogle Scholar
  3. 3.
    Jugdaohsingh R, Anderson SH, Tucker KL, Elliott H, Kiel DP, Thompson RP, Powell JJ. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887–893PubMedGoogle Scholar
  4. 4.
    Reffitt DM, Ogston N, Jugdaohsingh R, Cheung HF, Evans BA, Thompson RP, Powell JJ, Hampson GN. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone 2003;32:127–135CrossRefPubMedGoogle Scholar
  5. 5.
    Robberecht H, Van Cauwenbergh R, Van Vlaslaer V, Hermans N. Dietary silicon intake in Belgium: Sources, availability from foods, and human serum levels. Sci Total Environ 2009;407:4777–4782CrossRefPubMedGoogle Scholar
  6. 6.
    Jugdaohsingh R, Tucker KL, Qiao N, Cupples LA, Kiel DP, Powell JJ. Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res 2004;19:297–307CrossRefPubMedGoogle Scholar
  7. 7.
    Bae YJ, Kim JY, Choi MK, Chung YS, Kim MH. Short-term administration of water-soluble silicon improves mineral density of the femur and tibia in ovariectomized rats. Biol Trace Elem Res 2008;124:157–163CrossRefPubMedGoogle Scholar
  8. 8.
    Li Z, Karp H, Zerlin A, Lee TY, Carpenter C, Heber D. Absorption of Silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study. Nutr J 2010;9:44PubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Woo DG, Lee BY, Lim D, Kim HS. Relationship between nutrition factors and osteopenia: Effects of experimental diets on immature bone quality. J Biomech 2009. 42:1102–1107.CrossRefPubMedGoogle Scholar
  10. 10.
    Aaseth J, Boivin G, Andersen. Osteoporosis and trace elements: an overview. J Trace Elem Med Biol 2012;26:149–152.CrossRefPubMedGoogle Scholar
  11. 11.
    Carlisle EM. Silicon: a possible factor in bone calcification. Science 1970;167:279–328CrossRefPubMedGoogle Scholar
  12. 12.
    Carlisle EM. Silicon: an essential element for the chick. Science 1972;178:619–621CrossRefPubMedGoogle Scholar
  13. 13.
    Carlisle EM. In vivo requirement for Silicon in articular cartilage and connective tissue formation in the chick. J Nutr 1976;106:478–484PubMedGoogle Scholar
  14. 14.
    Carlisle EM. A Silicon requirement for normal skull formation in chicks. J Nutr 1980;110:352–359.PubMedGoogle Scholar
  15. 15.
    Carlisle EM. The nutritional essentiality of Silicon. Nutr Rev 1982;40:193–198CrossRefPubMedGoogle Scholar
  16. 16.
    Hott M, de Pollak C, Modrowski D, Marie PJ. Short-term effects of organic Silicon on trabecular bone in mature ovariectomized rats. Calcif Tissue Int 1993;53:174–179CrossRefPubMedGoogle Scholar
  17. 17.
    Seaborn CD, Nielsen FH. Effects of germanium and Silicon on bone mineralization. Biol Trace Elem Res 1994;42:151–164CrossRefPubMedGoogle Scholar
  18. 18.
    Seaborn CD, Nielsen FH. Dietary Silicon and arginine affect mineral element composition of rat femur and vertebra. Biol Trace Elem Res 2002;89:239–250CrossRefPubMedGoogle Scholar
  19. 19.
    Rico H, Gallego-Lago JL, Hernández ER, Villa LF, Sanchez-Atrio A, Seco C. Gérvas JJ. Effect of Silicon supplement on osteopenia induced by ovariectomy in rats. Calcif Tissue Int 2000;66:53–55CrossRefPubMedGoogle Scholar
  20. 20.
    Calomme M, Geusens P, Demeester N, Behets GJ, D’Haese P, Sindambiwe JB, Van Hoof V, Vanden Berghe D. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized Orthosilicic acid. Calcif Tissue Int 2006;78:227–232.CrossRefPubMedGoogle Scholar
  21. 21.
    Kim MH, Bae YJ, Choi MK, Chung YS. Silicon supplementation improves the bone mineral density of calcium-deficient ovariectomized rats by reducing bone resorption. Biol Trace Elem Res 2009;128:239–247CrossRefPubMedGoogle Scholar
  22. 22.
    Kayongo-Male H, Julson JL. Effects of high levels of dietary Silicon on bone development of growing rats and turkeys fed semi-purified diets. Biol Trace Elem Res 2008;123:191–201CrossRefPubMedGoogle Scholar
  23. 23.
    McNaughton SA, Bolton-Smith C, Mishra GD, Jugdaohsingh R, Powell JJ. Dietary Silicon intake in post-menopausal women. Br J Nutr 2005;94:813–817CrossRefPubMedGoogle Scholar
  24. 24.
    Spector TD, Calomme MR, Anderson SH, Clement G, Bevan L, Demeester N, Swaminathan R, Jugdaohsingh R, Berghe DA, Powell JJ. Choline-stabilized Orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. BMC Musculoskelet Disord 2008;9:85.PubMedCentralCrossRefPubMedGoogle Scholar
  25. 25.
    Macdonald HM, Hardcastle AC, Jugdaohsingh R, Fraser WD, Reid DM, Powell JJ. Dietary Silicon interacts with oestrogen to influence bone health: evidence from the Aberdeen Prospective Osteoporosis Screening Study. Bone 2012;50:681–687.CrossRefPubMedGoogle Scholar
  26. 26.
    Shie MY, Ding SJ, Chang HC. The role of Silicon in osteoblast-like cell proliferation and apoptosis. Acta Biomater 2011;7:2604–2614.CrossRefPubMedGoogle Scholar
  27. 27.
    Kim EJ, Bu SY, Sung MK, Choi MK. Effects of Silicon on Osteoblast Activity and Bone Mineralization of MC3T3-E1 Cells. Biol Trace Elem Res 2013;152:105–112.CrossRefPubMedGoogle Scholar
  28. 28.
    Zou S, Ireland D, Brooks RA, Rushton N, Best S. The effects of silicate ions on human osteoblast adhesion, proliferation, and differentiation. J Biomed Mater Res B Appl Biomater 2009;90:123–130PubMedGoogle Scholar
  29. 29.
    Anderson SI, Downes S, Perry CC, Caballero AM. Evaluation of the osteoblast response to a silica gel in vitro. J Mater Sci Mater Med 1998;9:731–735CrossRefPubMedGoogle Scholar
  30. 30.
    Wiens M, Wang X, Schlossmacher U, Lieberwirth I, Glasser G, Ushijima H. Schröder HC, Müller WE. Osteogenic potential of biosilica on human osteoblast-like (SaOS-2) cells. Calcif. Tissue Int 2010;87:513–524CrossRefGoogle Scholar
  31. 31.
    Mieszawska AJ, Fourligas N, Georgakoudi I, Ouhib NM, Belton DJ, Perry CC, Kaplan DL. Osteoinductive silk-silica composite biomaterials for bone regeneration. Biomaterials 2010;31:8902–8910PubMedCentralCrossRefPubMedGoogle Scholar
  32. 32.
    Ganesh N, Jayakumar R, Koyakutty M, Mony U, Nair SV. Embedded silica nanoparticles in poly(caprolactone) nanofibrous scaffolds enhanced osteogenic potential for bone tissue engineering. Tissue Eng Part A 2012;18:1867–1881CrossRefPubMedGoogle Scholar
  33. 33.
    Pelaez-Vargas A, Gallego-Perez D, Magallanes-Perdomo M, Fernandes MH, Hansford DJ, De Aza AH, Pena P, Monteiro FJ. Isotropic micropatterned silica coatings on zirconia induce guided cell growth for dental implants. Dent Mater 2011;27:581–589CrossRefPubMedGoogle Scholar
  34. 34.
    Huang Z, Daniels RH, Enzerink RJ, Hardev V, Sahi V, Goodman SB. Effect of nanofiber-coated surfaces on the proliferation and differentiation of osteoprogenitors in vitro. Tissue Eng Part A 2008;14:1853–1859CrossRefPubMedGoogle Scholar
  35. 35.
    Midha S, van den Bergh W, Kim TB, Lee PD, Jones JR, Mitchell CA. Bioactive Glass Foam Scaffolds are Remodelled by Osteoclasts and Support the Formation of Mineralized Matrix and Vascular Networks In Vitro. Adv Health Mater 2013;2:490–499CrossRefGoogle Scholar
  36. 36.
    Duan W, Ning C, Tang T. Cytocompatibility and osteogenic activity of a novel calcium phosphate silicate bioceramic: Silicocarnotite. J Biomed Mater Res A 2012Google Scholar
  37. 37.
    Toskas G, Cherif C, Hund RD, Laourine E, Mahltig B, Fahmi A, Heinemann C, Hanke T. Chitosan(PEO)/silica hybrid nanofibers as a potential biomaterial for bone regeneration. Carbohydr Polym 2013;94:713–722CrossRefPubMedGoogle Scholar
  38. 38.
    Lehmann G, Cacciotti I, Palmero P, Montanaro L, Bianco A, Campagnolo L, Camaioni A. Differentiation of osteoblast and osteoclast precursors on pure and Silicon-substituted synthesized hydroxyapatites. Biomed Mater 2012;7:055001CrossRefPubMedGoogle Scholar
  39. 39.
    Chaudhari A, Braem A, Vleugels J, Martens JA, Naert I, Cardoso MV, Duyck J. Bone tissue response to porous and functionalized titanium and silica based coatings. PLoS One 2011;6: e24186PubMedCentralCrossRefPubMedGoogle Scholar
  40. 40.
    Coathup MJ, Samizadeh S, Fang YS, Buckland T, Hing KA, Blunn GW. The osteoinductivity of silicate-substituted calcium phosphate. J Bone Joint Surg Am 2011;93:2219–2226CrossRefPubMedGoogle Scholar
  41. 41.
    Coathup MJ, Cai Q, Campion C, Buckland T, Blunn GW. The effect of particle size on the osteointegration of injectable silicate-substituted calcium phosphate bone substitute materials. J Biomed Mater Res B Appl Biomater, 2013Google Scholar
  42. 42.
    Beck GR Jr, Ha SW, Camalier CE, Yamaguchi M, Li Y, Lee JK, Weitzmann MN. Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-res orbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine 2012;8:793–803PubMedCentralCrossRefPubMedGoogle Scholar
  43. 43.
    El-Gendy R, Yang XB, Newby PJ, Boccaccini AR, Kirkham J. Osteogenic differentiation of human dental pulp stromal cells on 45S5 Bioglass? based scaffolds in vitro and in vivo. Tissue Eng Part A 2013;19:707–715PubMedCentralCrossRefPubMedGoogle Scholar
  44. 44.
    Jun SH, Lee EJ, Jang TS, Kim HE, Jang JH, Koh YH. Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering. J Mater Sci Mater Med 2013;24:773–782CrossRefPubMedGoogle Scholar
  45. 45.
    Lee C, Cheong M, Hsiao W, Liu H, Tsai C, Wang M, Wu C, Chang K, Lam G, Deng W. Use of iQPR-H2O for bone regeneration and its potential in the improvement of osteoporosis. BMC Musculoskelet Disord 2011;12:227PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Serdi and Springer-Verlag France 2014

Authors and Affiliations

  • Luigi Fabrizio Rodella
    • 1
    Email author
  • V. Bonazza
    • 1
  • M. Labanca
    • 1
  • C. Lonati
    • 1
  • R. Rezzani
    • 1
  1. 1.Section of Anatomy and Physiopathology, Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly

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