Cognitive frailty

This is a preview of subscription content, access via your institution.


  1. 1.

    Buchman AS, Wilson RS, Bienias JL, Shah RC, Evans DA, Bennett DA. Change in body mass index and risk of incident Alzheimer disease. Neurology. Sep 27 2005;65(6):892–897.

    CAS  PubMed  Article  Google Scholar 

  2. 2.

    Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol. Nov 2009;66(11):1339–1344.

    PubMed Central  PubMed  Article  Google Scholar 

  3. 3.

    Buracchio T, Dodge HH, Howieson D, Wasserman D, Kaye J. The Trajectory of Gait Speed Preceding Mild Cognitive Impairment. Arch Neurol. August 1, 2010 2010;67(8):980–986.

    PubMed Central  PubMed  Article  Google Scholar 

  4. 4.

    Verghese J, Wang C, Lipton RB, Holtzer R, Xue X. Quantitative gait dysfunction and risk of cognitive decline and dementia. Journal of Neurology, Neurosurgery, and Psychiatry. 9/1 2007;78(9):929–935.

    PubMed Central  PubMed  Article  Google Scholar 

  5. 5.

    Camicioli R, Howieson D, Oken B, Sexton G, Kaye J. Motor slowing precedes cognitive impairment in the oldest old. Neurology. May 1998;50(5):1496–1498.

    CAS  PubMed  Article  Google Scholar 

  6. 6.

    Gustafson D. Adiposity indices and dementia. Lancet Neurol. Aug 2006;5(8):713–720.

    PubMed  Article  Google Scholar 

  7. 7.

    Wilson RS, Barnes LL, Mendes de Leon CF, et al. Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology. Aug 13 2002;59(3):364–370.

    PubMed  Article  Google Scholar 

  8. 8.

    Abellan van Kan G, Rolland Y, Gillette-Guyonnet S, et al. Gait Speed, Body Composition, and Dementia. The EPIDOS-Toulouse Cohort. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. April 1, 2012 2012;67A(4):425–432.

    Article  Google Scholar 

  9. 9.

    Buchman AS, Yu L, Wilson RS, Schneider JA, Bennett DA. Association of brain pathology with the progression of frailty in older adults. Neurology. May 28 2013;80(22):2055–2061.

    CAS  PubMed  Article  Google Scholar 

  10. 10.

    Wilson RS, Leurgans SE, Boyle PA, Schneider JA, Bennett DA. Neurodegenerative basis of age-related cognitive decline. Neurology. 2010;75(12):1070–1078.

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  11. 11.

    Buchman AS, Nag S, Shulman JM, et al. Locus coeruleus neuron density and parkinsonism in older adults without Parkinson’s disease. Mov Disord. Nov 2012;27(13):1625–1631.

    PubMed Central  PubMed  Article  Google Scholar 

  12. 12.

    Wilson RS, Nag S, Boyle PA, et al. Neural reserve, neuronal density in the locus ceruleus, and cognitive decline. Neurology. Mar 26 2013;80(13):1202–1208.

    PubMed Central  PubMed  Article  Google Scholar 

  13. 13.

    Jack CR, Jr., Albert M, Knopman DS, et al. Introduction to revised criteria for the diagnosis of Alzheimer’s disease: National Institute on Aging and the Alzheimer’s Association workgroup. Alzheimers Dement. Apr 20 2011.

    Google Scholar 

  14. 14.

    Lang AE. A critical appraisal of the premotor symptoms of Parkinson’s disease: Potential usefulness in early diagnosis and design of neuroprotective trials. Movement Disorders. 2011;26(5):775–783.

    PubMed  Article  Google Scholar 

  15. 15.

    Tanne D, Levine SR. Capturing the Scope of Stroke: Silent, Whispering, and Overt. Archives of Neurology. 2009;66(7):819–820.

    PubMed  Article  Google Scholar 

  16. 16.

    Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. Mar 2001;56(3):M146–156.

    CAS  PubMed  Article  Google Scholar 

  17. 17.

    Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia. Neurology. July 6, 2010 2010;75(1):35–41.

    CAS  PubMed Central  PubMed  Article  Google Scholar 

  18. 18.

    Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. Mar 2006;63(3):273–279.

    PubMed  Article  Google Scholar 

  19. 19.

    Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry. Feb 2008;16(2):168–174.

    PubMed  Article  Google Scholar 

  20. 20.

    Tsopelas C, Stewart R, Savva GM, et al. Neuropathological correlates of late-life depression in older people. Br J Psychiatry. Feb 2011;198(2):109–114.

    PubMed  Article  Google Scholar 

  21. 21.

    Buchman A, Boyle P, Wilson R, et al. Loneliness and the rate of motor decline in old age: the rush memory and aging project, a community-based cohort study. BMC Geriatrics. 2010;10(1):77.

    PubMed Central  PubMed  Article  Google Scholar 

  22. 22.

    Avila-Funes JA, Amieva H, Barberger-Gateau P, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc. Mar 2009;57(3):453–461.

    PubMed  Article  Google Scholar 

  23. 23.

    Rebok GW, Carlson MC, Langbaum JB. Training and maintaining memory abilities in healthy older adults: traditional and novel approaches. J Gerontol B Psychol Sci Soc Sci. Jun 2007;62 Spec No 1:53–61.

    PubMed  Article  Google Scholar 

  24. 24.

    Cesari M, Vellas B, Gambassi G. The stress of aging. Experimental Gerontology. 4// 2013;48(4):451–456.

    Article  Google Scholar 

  25. 25.

    Subra J, Gillette-Guyonnet S, Cesari M, Oustric S, Vellas B. The integration of frailty into clinical practice: preliminary results from the Gerontopole. J Nutr Health Aging. Aug 2012;16(8):714–720.

    CAS  PubMed  Article  Google Scholar 

  26. 26.

    Yu L, Buchman AS, Boyle PA, et al. Simultaneous changes in cognition and physical frailty and association of neuropathology. Paper presented at: Alzheimer’s Association International Conference 2013; Boston, MA, USA.

    Google Scholar 

  27. 27.

    Boyle PA, Wilson RS, Yu L, et al. Much of late life cognitive decline is not due to common neurodegenerative pathologies. Annals of Neurology. 2013:n/a-n/a.

    Google Scholar 

  28. 28.

    Wilson RS, Segawa E, Buchman AS, Boyle PA, Hizel LP, Bennett DA. Terminal Decline in Motor Function. Psych & Aging. 2012.

    Google Scholar 

Download references

Author information



Corresponding author

Correspondence to David A. Bennett.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Buchman, A.S., Bennett, D.A. Cognitive frailty. J Nutr Health Aging 17, 738–739 (2013).

Download citation


  • Depressive Symptom
  • Cognitive Decline
  • Physical Frailty
  • Motor Control System
  • Change Point Model