To examine the association between metabolic syndrome (MetS) and/or its components and colorectal neoplasms in adult population undergoing screening colonoscopy.
Institute of Gastroenterology, Kaplan Medical Center, Rehovot, Israel.
Two hundred ninety nine consecutive outpatients undergoing screening colonoscopy.
MetS was determined according to the Adult Treatment Panel III of the National Cholesterol Education Program (ATP III) criteria. Blood test results and other clinical data were retrieved from the electronic medical records.
In 94 patients (31.8%) polyps were detected. Thirty two (34%) of the polyps were advanced. Eighty one percent of patients with an advanced polyp met the criteria for MetS. About the same MetS prevalence (84%) was found in men, but not in women. An advanced polyp was detected in 14% of patients with MetS, compared to 5% of patients without MetS. Odds ratio for having an advanced polyp in a patient with MetS compared to a patient without MetS was 10.64.
MetS was found to be a risk factor for advanced polyps. This association is suggestive of the need that patients with MetS should be urged to have a screening colonoscopy.
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Faivre J, Bouvier AM, Bonithon-Kopp C. Epidemiology and screening of colorectal cancer. Best Pract Res Clin Gastroenterol 2002; 16:187–199.
Armelao F, Paternolli C, Franceschini G, et al. Colonoscopic findings in first-degree relatives of patients with colorectal cancer: a population-based screening program. Gastrointest Endos 2011; 73:527–534.
Hu N Ch, Chen JD, Lin YM, Chang JY, Chen YH. Stepwise relationship between components of metabolic syndrome and risk of colorectal adenoma in a Taiwanese population receiving screening colonoscopy. J Formos Med Assoc 2011; 110:100–108.
Lee GE, Park HS, Yun KE, Jun SH, Kim HK, Cho SI, Kim JH. Association between BMI and metabolic syndrome and adenomatous colonic polyps in Korean men. Obesity (Silver Spring) 2008; 16:1434–1439.
Wang YY, Lin SY, Lai WA, Liu PH, Sheu WH. Association between adenomas of the rectosigmoid colon and metabolic syndrome features in a Chinese population. J Gastroenterol Hepatol 2005; 20:1410–1415.
Giovannucci E. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr 2007; 86(Suppl):836S–842S.
Pelucchi C, Negri E, Talamini R, Levi F, Giacosa A, Crispo A, Bidoli E, Montella M, Franceschi S, La Vecchia C. Metabolic syndrome is associated with colorectal cancer in men. Eur J Cancer 2010; 46:1866–1872.
Russo A, Autelitano M, Bisanti L. Metabolic syndrome and cancer risk. Eur J Cancer 2008; 44:293–297.
Johnson LW, Weinstock RS. The metabolic syndrome: concepts and controversy. Mayo Clin Proc 2006; 81:1615–1620.
Lieberman D, Moravec M, Holub J, Michaels L, Eisen G. Polyp size and advanced histology in patients undergoing colonoscopy screening: implications for CT colonography. Gastroenterology 2008; 135:1100–1105.
Kim MC, Jung SW, Kim CS, Chung TH, Yoo CI, Park NH. Metabolic syndrome is associated with increased risk of recurrent colorectal adenomas in Korean men. Inter J Obesity 2011; 17:4031–4037.
Liu CS, Hsu HS, Li CI, et al. Central obesity and atherogenic dyslipidemia in metabolic syndrome are associated with increased risk for colorectal adenoma in a Chinese population. BMC Gastroenterology 2010; 10:51.
Siddiqui AA. Metabolic Syndrome and its association with colorectal cancer: a review. Am J Med Sci 2011; 341:227–231.
Ortiz AP, Thompson ChL, Chak A, Berger NA, Li L. Insulin resistance, central obesity, and risk of colorectal adenomas. Cancer 2011; 118:1774–1781.
Shen Z, Wang S, Ye Y, Yin M, Yang X, Jiang K, Liu Y. Clinical study on the correlation between metabolic syndrome and colorectal carcinoma. ANZ J Surg 2010; 80:331–336.
Morita T, Tabata S, Mineshita M, Mizoue T, Moore MA, Kono S. The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense forces health study. Asian Pac Cancer Prev 2005; 6:485–489.
Kim JH, Lim YJ, Kim YH, Sung IK, Shim SG, Oh SO, Park SS, Yang S, Son HJ, Rhee PL, Kim JJ, Rhee JC, Choi YH. Is metabolic syndrome a risk factor for colorectal adenoma? Cancer Epidemiol Biomarkers Prev 2007; 16:1543–1546.
Inoue M, Noda M, Kurahashi N, Iwasaki M, Sasazuki S, Iso H, Tsugane S. Impact of metabolic factors on subsequent cancer risk: results from a large-scale populationbased cohort study in Japan. Eur J Cancer Prev 2009; 18:240–247.
Sturmer T, Buring JE, Lee IM, Gaziano JM, Glynn RJ. Metabolic abnormalities and risk for colorectal cancer in the physicians’ health study. Cancer Epidemiol Biomarkers Prev 2006; 15:2391–2397.
Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR. The metabolic syndrome and risk of incident colorectal cancer. Cancer 2006; 107:28–36.
Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002; 288:321–333.
Pischon T, Lahmann PH, Boeing H, et al. Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2006; 98:920–931.
Cowey S, Hardy RW. The metabolic syndrome: A high-risk state for cancer? Am J Pathol 2006; 169:1505–1522.
Limburg PJ, Anderson KE, Johnson TW, Jacobs DR Jr, Lazovich D, Hong CP. Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women’s Health Study. Cancer Epidemiol Biomarkers Prev 2005; 14:133–137.
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Tal, S., Melzer, E., Chsherbakov, T. et al. Metabolic syndrome is associated with increased prevalence of advanced colorectal polyps. J Nutr Health Aging 18, 22–25 (2014). https://doi.org/10.1007/s12603-013-0360-9
- Metabolic syndrome
- non-advanced polyps
- advanced polyps