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A review of multidomain interventions to support healthy cognitive ageing

The journal of nutrition, health & aging volume 17, pages 252–257 (2013)Cite this article

Abstract

Objective

The risk for cognitive decline and for developing Alzheimer’s disease increases with age. The aetiology is assumed to be of multi-factorial origin, and treatment opportunities are lacking. Despite the multi-factorial origin, many intervention studies focused on single factors to influence cognitive health with inconsistent findings. In this view, more and more intervention studies aim to intervene on multiple factors simultaneously to affect or slow down cognitive decline. The purpose of this paper is to give an overview of these multidomain intervention trials.

Methods

We conducted a non-systematic literature search in Medline, Scopus, Cochrane Library, and clinical trials databases up to October 2011 to review multidomain interventions that investigated effects of combined lifestyle-related factors on cognitive decline and the progression of dementia.

Results

Interest in multidomain interventions increased over the past years. We identified six completed and published trials and eight ongoing or not yet published studies that investigated effects on cognitive outcomes. First completed trials yielded promising results for the combination of exercise and mental training and diet and behavioural weight management. Results of ongoing multidomain trials are awaited.

Conclusions

Some evidence suggests that strategies which target multiple factors simultaneously may prove more effective than those focusing on a single mechanism or domain. Larger high-quality randomized controlled trials are required to systematically investigate the cognitive effect of programs comprising physical and mental activity as well as nutritional aspects.

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References

  1. Fratiglioni L, Qiu C (2009) Prevention of common neurodegenerative disorders in the elderly. Exp Gerontol 44:46–50

    PubMed  Article  Google Scholar 

  2. Brookmeyer R, Gray S (2000) Methods for projecting the incidence and prevalence of chronic diseases in aging populations: application to Alzheimer’s disease. Stat Med 19:1481–1493

    PubMed  Article  CAS  Google Scholar 

  3. Qiu C, Kivipelto M, von SE (2009) Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11:111–128

    PubMed  Google Scholar 

  4. Whalley LJ, Dick FD, McNeill G (2006) A life-course approach to the aetiology of late-onset dementias. Lancet Neurol 5:87–96

    PubMed  Article  Google Scholar 

  5. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60:1119–1122

    PubMed  Article  Google Scholar 

  6. Chertkow H, Massoud F, Nasreddine Z, Belleville S, Joanette Y, Bocti C, Drolet V, Kirk J, Freedman M, Bergman H (2008) Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia. CMAJ 178:1273–1285

    PubMed  Google Scholar 

  7. Middleton LE, Yaffe K (2009) Promising strategies for the prevention of dementia. Arch Neurol 66:1210–1215

    PubMed  Article  Google Scholar 

  8. Malouf R, Grimley EJ (2008) Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst RevCD004514

  9. Duron E, Hanon O (2008) Vascular risk factors, cognitive decline, and dementia. Vasc Health Risk Manag 4:363–381

    PubMed  CAS  Google Scholar 

  10. Debette S, Bombois S, Bruandet A, Delbeuck X, Lepoittevin S, Delmaire C, Leys D, Pasquier F (2007) Subcortical hyperintensities are associated with cognitive decline in patients with mild cognitive impairment. Stroke 38:2924–2930

    PubMed  Article  Google Scholar 

  11. Fillit H, Nash DT, Rundek T, Zuckerman A (2008) Cardiovascular risk factors and dementia. Am J Geriatr Pharmacother 6:100–118

    PubMed  Article  Google Scholar 

  12. Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR, Breitner JC, DeGroodt W, Mehta P, Craft S (2008) Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 70:440–448

    PubMed  Article  CAS  Google Scholar 

  13. Craft S, Baker LD, Montine TJ, Minoshima S, Watson GS, Claxton A, Arbuckle M, Callaghan M, Tsai E, Plymate SR, Green PS, Leverenz J, Cross D, Gerton B (2011) Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial. Arch Neurol Epub ahead of print

  14. Ball K, Edwards JD, Ross LA (2007) The impact of speed of processing training on cognitive and everyday functions. J Gerontol B Psychol Sci Soc Sci 62 Spec No 1:19–31

    PubMed  Article  Google Scholar 

  15. Colcombe S, Kramer AF (2003) Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci 14:125–130

    PubMed  Article  Google Scholar 

  16. Kramer AF, Erickson KI, Colcombe SJ (2006) Exercise, cognition, and the aging brain. J Appl Physiol 101:1237–1242

    PubMed  Article  Google Scholar 

  17. Ravaglia G, Forti P, Lucicesare A, Pisacane N, Rietti E, Bianchin M, Dalmonte E (2008) Physical activity and dementia risk in the elderly: findings from a prospective Italian study. Neurology 70:1786–1794

    PubMed  Article  CAS  Google Scholar 

  18. Rockwood K, Middleton L (2007) Physical activity and the maintenance of cognitive function. Alzheimers Dement 3:S38–S44

    PubMed  Article  Google Scholar 

  19. Rovio S, Kareholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M (2005) Leisure-time physical activity at midlife and the risk of dementia and Alzheimer’s disease. Lancet Neurol 4:705–711

    PubMed  Article  Google Scholar 

  20. van Uffelen JG, Chin APM, Hopman-Rock M, van MW (2008) The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review. Clin J Sport Med 18:486–500

    PubMed  Article  Google Scholar 

  21. Ahlskog JE, Geda YE, Graff-Radford NR, Peterson RC (2011) Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging. Mayo Clinic Proceedings 86:876–884

    PubMed  Article  Google Scholar 

  22. Unverzagt FW, Kasten L, Johnson KE, Rebok GW, Marsiske M, Koepke KM, Elias JW, Morris JN, Willis SL, Ball K, Rexroth DF, Smith DM, Wolinsky FD, Tennstedt SL (2007) Effect of memory impairment on training outcomes in ACTIVE. J Int Neuropsychol Soc 13:953–960

    PubMed  Google Scholar 

  23. Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61:1402S–1406S

    PubMed  CAS  Google Scholar 

  24. Feart C, Samieri C, Barberger-Gateau P (2010) Mediterranean diet and cognitive function in older adults. Curr Opin Clin Nutr Metab Care 13:14–18

    PubMed  Article  CAS  Google Scholar 

  25. Karp A, Paillard-Borg S, Wang HX, Silverstein M, Winblad B, Fratiglioni L (2006) Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord 21:65–73

    PubMed  Article  Google Scholar 

  26. Paillard-Borg S, Fratiglioni L, Winblad B, Wang HX (2009) Leisure activities in late life in relation to dementia risk: principal component analysis. Dement Geriatr Cogn Disord 28:136–144

    PubMed  Article  Google Scholar 

  27. Akbaraly TN, Portet F, Fustinoni S, Dartigues JF, Artero S, Rouaud O, Touchon J, Ritchie K, Berr C (2009) Leisure activities and the risk of dementia in the elderly: results from the Three-City Study. Neurology 73:854–861

    PubMed  Article  CAS  Google Scholar 

  28. Oswald WD, Gunzelmann T, Rupprecht R, Hagen B (2006) Differential effects of single versus combined cognitive and physical training with older adults: the SimA study in a 5-year perspective. Eur J Ageing 179–192

  29. Oswald WD, Rupprecht R, Gunzelmann T, Tritt K (1996) The SIMA-project: effects of 1 year cognitive and psychomotor training on cognitive abilities of the elderly. Behav Brain Res 78:67–72

    PubMed  Article  CAS  Google Scholar 

  30. Fabre C, Chamari K, Mucci P, Masse-Biron J, Prefaut C (2002) Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects. Int J Sports Med 23:415–421

    PubMed  Article  CAS  Google Scholar 

  31. Legault C, Jennings JM, Katula JA, Dagenbach D, Gaussoin SA, Sink KM, Rapp SR, Rejeski WJ, Shumaker SA, Espeland MA (2011) Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: The Seniors Health and Activity Research Program Pilot (SHARP-P) Study, a randomized controlled trial. Geriatrics 11

  32. de Jong N, Paw M, de Groot L, Rutten R, Swinkels D, Kok F, van Staveren W (2001) Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning. Am J Clin Nutr 73:338–346

    PubMed  Google Scholar 

  33. Cetin E, Top EC, Sahin G, Özkaya YG, Aydin H, Toraman F (2010) Effect of vitamin E supplementation with exercise on cognitive functions and total antioxidant capacity in older people. The Journal of Nutrition, Health & Aging 14:763–769

    Article  CAS  Google Scholar 

  34. Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, Strauman TA, Sherwood A (2010) Effects of the Dietary Approaches to Stop Hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension 55:1331–1338

    PubMed  Article  CAS  Google Scholar 

  35. O’Dwyer ST, Burton NW, Pachana NA, Brown WJ (2007) Protocol for Fit Bodies, Fine Minds: a randomized controlled trial on the affect of exercise and cognitive training on cognitive functioning in older adults. Geriatrics 7

  36. Komulainen P, Pedersen M, Hänninen T, Bruunsgard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R (2008) BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study. Neurobiology of Learning and Memory 90:596–603

    PubMed  Article  CAS  Google Scholar 

  37. Gates NJ, Valenzuela M, Sachdev PS, Singh NA, Baune BT, Brodaty H, Suo C, Jain N, Wilson GC, Wang Y, Baker MK, Williamson D, Foroughi N, Fiatarone Singh MA (2011) Study of mental activity and regular training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial. Geriatrics 11

  38. Coley N, Andrieu S, Gardette V, Gillette-Guyonnet S, Sanz C, Vellas B, Grand A (2008) Dementia prevention: methodological explanations for inconsistent results. Epidemiol Rev 30:35–66

    PubMed  Article  Google Scholar 

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Authors and Affiliations

  1. Nestec Ltd., Nestlé Research Center Lausanne, Lausanne, Switzerland

    N. Schneider & C. Yvon

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  1. N. Schneider
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  2. C. Yvon
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Schneider, N., Yvon, C. A review of multidomain interventions to support healthy cognitive ageing. J Nutr Health Aging 17, 252–257 (2013). https://doi.org/10.1007/s12603-012-0402-8

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  • DOI: https://doi.org/10.1007/s12603-012-0402-8

Key words

  • Healthy ageing
  • multidomain interventions
  • mental activity
  • physical activity
  • diet.