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Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration



To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area.


A case-control study.


56 AMD patients (21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied.


Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity — TAC) were determined.


There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls.


Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.

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Correspondence to Xueli Shen.

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Shen, X., Jia, L.H., Zhao, P. et al. Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration. J Nutr Health Aging 16, 201–204 (2012).

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Key words

  • Antioxidant capacity
  • malondialdehyde
  • chinese
  • age-related macular degeneration