Abstract
Objectives
Growth and sex steroid hormones decrease with aging and obesity. The effect of dietary weight loss and exercise training lifestyle interventions was examined on hormones as well as determining their relationships with physical function in older obese and overweight adults.
Design
Individuals were randomized into one of four 18 month interventions: Healthy Lifestyle (HL), Exercise, Diet, and Exercise-Diet.
Setting
Clinical research setting with facility based exercise and nutrition education and behavior classrooms.
Participants
Older (≥60 yrs) overweight and obese (BMI≥28 kg/m2) adults with knee osteoarthritis (n=309) were recruited for the study.
Intervention
Weight loss goal for Diet groups was ≥5%. Exercise groups trained (mostly walking and resistance training) 3 days/week for 60 min/session.
Measurements
Body weight, growth hormone (GH), corticosterone, sex-hormone binding globulin (SHBG), testosterone, and dehydroepiandrosterone (DHEA) were measured at baseline, 6, and 18 months. Physical function was determined through performance task (6- min walking distance) and self-reported questionnaires (Western Ontario McMaster University Osteoarthritis Index-WOMAC) at similar time points.
Results
Diet, Exercise, and Exercise-Diet groups lost 4.9%, 3.5%, and 6.2% of their weight at 18 months, respectively. There was a significant diet treatment effect on GH levels in women as higher concentrations of this hormone were apparent following dietary weight loss intervention (p=0.01). No other hormones were affected by either diet or exercise treatments in men or women. A significant inverse correlation between baseline 6-minute walking distance and SHBG (r=−0.33) was found in men.
Conclusion
The increase in basal GH levels from the diet treatment in women suggests that this lifestyle behavior intervention may mitigate the age- and obesity-related decreases in growth hormone levels, to help preserve muscle mass, strength, and physical function in older adults.
Similar content being viewed by others
References
Roy TA, Blackman MR, Harman SM, Tobin JD, Schrager M, Metter EJ. Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men. Am J Physiol Endocrinol Metab. 2002;283(2):E284–E294.
Brill KT, Weltman AL, Gentili A et al. Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. J Clin Endocrinol Metab. 2002;87(12):5649–5657.
Woodhouse LJ, Asa SL, Thomas SG, Ezzat S. Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults. J Clin Endocrinol Metab. 1999;84(12):4570–4577.
Woodhouse LJ, Mukherjee A, Shalet SM, Ezzat S. The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults. Endocr Rev. 2006;27(3):287–317.
Veldhuis JD, Iranmanesh A, Weltman A. Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans. Endocrine. 1997;7(1):41–48.
Svartberg J, Midtby M, Bonaa KH, Sundsfjord J, Joakimsen RM, Jorde R. The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. Eur J Endocrinol. 2003;149(2):145–152.
Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86(2):724–731.
Bjornerem A, Straume B, Midtby M et al. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromso Study. J Clin Endocrinol Metab. 2004;89(12):6039–6047.
Couillard C, Gagnon J, Bergeron J et al. Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study. J Clin Endocrinol Metab. 2000;85(3):1026–1031.
Guralnik JM, Simonsick EM. Physical disability in older Americans. J Gerontol. 1993;48 Spec No:3–10.
Freedman VA, Martin LG. Understanding trends in functional limitations among older Americans. Am J Public Health. 1998;88(10):1457–1462.
Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004;6(3):208–215.
Rasmussen MH, Juul A, Kjems LL, Skakkebaek NE, Hilsted J. Lack of stimulation of 24-hour growth hormone release by hypocaloric diet in obesity. J Clin Endocrinol Metab. 1995;80(3):796–801.
Cooper CS, Taaffe DR, Guido D, Packer E, Holloway L, Marcus R. Relationship of chronic endurance exercise to the somatotropic and sex hormone status of older men. Eur J Endocrinol. 1998;138(5):517–523.
Nicklas BJ, Ryan AJ, Treuth MM et al. Testosterone, growth hormone and IGF-I responses to acute and chronic resistive exercise in men aged 55–70 years. Int J Sports Med. 1995;16(7):445–450.
Miller GD, Rejeski WJ, Williamson JD et al. The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results. Control Clin Trials. 2003;24(4):462–480.
Messier SP, Loeser RF, Miller GD et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum. 2004;50(5):1501–1510.
Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833–1840.
Miller GD, Nicklas BJ, Moser PM, Ellis T. Intensive Weight Loss in Older Obese Adults with Knee Osteoarthritis (OA): Effect on Physical Function. Obes Res. 2004;12 (11 (abstract)).
Verkasalo PK, Thomas HV, Appleby PN, Davey GK, Key TJ. Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom). Cancer Causes Control. 2001;12(1):47–59.
Laaksonen DE, Niskanen L, Punnonen K et al. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol. 2003;149(6):601–608.
Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev. 1993;14(1):20–39.
Liu H, Bravata DM, Olkin I et al. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med. 2007;146(2):104–115.
Grindeland RE, Roy RR, Edgerton VR et al. Interactive effects of growth hormone and exercise on muscle mass in suspended rats. Am J Physiol. 1994;267(1 Pt 2):R316–R322.
Grossman EJ, Grindeland RE, Roy RR, Talmadge RJ, Evans J, Edgerton VR. Growth hormone, IGF-I, and exercise effects on non-weight-bearing fast muscles of hypophysectomized rats. J Appl Physiol. 1997;83(5):1522–1530.
Giannoulis MG, Jackson N, Shojaee-Moradie F et al. The effects of growth hormone and/or testosterone on whole body protein kinetics and skeletal muscle gene expression in healthy elderly men: a randomized controlled trial. J Clin Endocrinol Metab. 2008;93(8):3066–3074.
Blackman MR, Sorkin JD, Munzer T et al. Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. JAMA. 2002;288(18):2282–2292.
Giannoulis MG, Sonksen PH, Umpleby M et al. The effects of growth hormone and/or testosterone in healthy elderly men: a randomized controlled trial. J Clin Endocrinol Metab. 2006;91(2):477–484.
Marzetti E, Groban L, Wohlgemuth SE et al. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol. 2008;294(2):R558–R567.
Abs R, Bengtsson BA, Hernberg-Stahl E et al. GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and clinical characteristics, dosing and safety. Clin Endocrinol (Oxf). 1999;50(6):703–713.
Cohn L, Feller AG, Draper MW, Rudman IW, Rudman D. Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations. Clin Endocrinol (Oxf). 1993;39(4):417–425.
Ho KY, Evans WS, Blizzard RM et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 1987;64(1):51–58.
Van CE, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000;284(7):861–868.
Latta F, Leproult R, Tasali E et al. Sex differences in nocturnal growth hormone and prolactin secretion in healthy older adults: relationships with sleep EEG variables. Sleep. 2005;28(12):1519–1524.
Parekh N, Roberts CB, Vadiveloo M, Puvananayagam T, Albu JB, Lu-Yao GL. Lifestyle, anthropometric, and obesity-related physiologic determinants of insulinlike growth factor-1 in the Third National Health and Nutrition Examination Survey (1988–1994). Ann Epidemiol. 2010;20(3):182–193.
Onder G, Liperoti R, Russo A et al. Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study. Am J Physiol Endocrinol Metab. 2006;291(4):E829–E834.
Hurel SJ, Koppiker N, Newkirk J et al. Relationship of physical exercise and ageing to growth hormone production. Clin Endocrinol (Oxf). 1999;51(6):687–691.
Hakkinen K, Pakarinen A, Kraemer WJ, Newton RU, Alen M. Basal concentrations and acute responses of serum hormones and strength development during heavy resistance training in middle-aged and elderly men and women. J Gerontol A Biol Sci Med Sci. 2000;55(2):B95–105.
Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB. Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf). 2006;65(1):125–131.
Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study [see comments]. Ann Intern Med. 1992;116(7):535–539.
Lawrence RC, Helmick CG, Arnett FC et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States [see comments]. Arthritis Rheum. 1998;41(5):778–799.
O’Donnell AB, Travison TG, Harris SS, Tenover JL, McKinlay JB. Testosterone, dehydroepiandrosterone, and physical performance in older men: results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 2006;91(2):425–431.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Miller, G.D., Nicklas, B.J., Davis, C.C. et al. Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women. J Nutr Health Aging 16, 169–174 (2012). https://doi.org/10.1007/s12603-011-0152-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12603-011-0152-z