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The journal of nutrition, health & aging

, Volume 15, Issue 2, pp 115–120 | Cite as

Thirteen-year prospective study between fish consumption, long-chain N-3 fatty acids intakes and cognitive function

  • E. Kesse-Guyot
  • S. Péneau
  • M. Ferry
  • C. Jeandel
  • S. Hercberg
  • P. Galan
  • The SU.VI.Max 2 Research Group
JNHA: Clinical Neurosciences

Abstract

Objectives

Because of their structural, anti-inflammatory and antithrombic properties, longchain n-3 fatty acids may be key factors in the aging process. We sought to elucidate the association between intake of long-chain n-3 fatty acids and/or fish and cognitive function evaluated 13 years after dietary assessment.

Design

Prospective population-based study.

Participants/Setting

3,294 adults from the SU.VI.MAX study (Supplementat ion with Antioxidant Vitamins and Minerals study).

Measurements/Statistical analysis

Subjects underwent a standardized clinical examination which included cognitive tests and self-reported cognitive difficulties scale (2007–2009). Poor scores were defined using percentiles as cut-off. Dietary data were assessed through repeated 24-h dietary records. Odd ratio (OR), comparing the fourth (Q4) to the first quartile (Q1), of having a poor score were calculated using adjusted logistic regression.

Results

Self-reported cognitive difficulties were less frequent among subjects with higher intakes of total n-3 long chain fatty acids (OR = 0.72, CI 95%=0.56–0.92) and eicosapentaenoic acid (OR Q4 versus Q1 = 0.74, CI 95%=0.58–0.95), even after adjustment for depressive symptoms. A borderline significant association was also found with high fish consumption (OR Q4 versus Q1 = 0.80, CI 95%=0.63−1.01).

Conclusion

Cognitive complaints, which may be an early indicator of cognitive decline, are less frequent among the elderly who have a high long-chain n-3 acids intake, as assessed 13 years earlier.

Key words

Cognition cognitive difficulties fish omega-3 fatty acids 

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Copyright information

© Serdi and Springer Verlag France 2011

Authors and Affiliations

  • E. Kesse-Guyot
    • 1
    • 4
  • S. Péneau
    • 2
  • M. Ferry
    • 1
  • C. Jeandel
    • 2
  • S. Hercberg
    • 1
    • 3
  • P. Galan
    • 1
  • The SU.VI.Max 2 Research Group
  1. 1.INSERM U557; INRA U1125; CNAM; Paris 13. Human Nutrition Research Center of Ile de FranceUFR SMBH Paris 13, SMBHBobigny cedexFrance
  2. 2.Centre de Gérontologie Clinique Antonin Balmes, CHU MontpellierUniversité IMontpellierFrance
  3. 3.Département de Santé PubliqueHôpital AvicenneBobignyFrance
  4. 4.INSERM U557; INRA U1125; CNAM; PARIS 13. Human Nutrition Research Center of Ile de FranceUFR SMBH Paris 13, SMBHBobigny cedexFrance

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