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Increased selenium intake in elderly high fish consumers may account for health benefits previously ascribed to omega-3 fatty acids

  • Claudine Berr
  • T. Akbaraly
  • J. Arnaud
  • I. Hininger
  • A.-M. Roussel
  • P. Barberger Gateau
Article

Abstract

Objective

To examine relationships between fish consumption and plasma selenium (Se) and red blood-cell fatty acid (RBC FA) profile in aged subjects. We hypothesised that the importance of Se has been underestimated when interpreting the beneficial effect of fish consumption on health.

Design

Cross-sectional analysis of data from a prospective cohort study.

Setting

The EVA study in Nantes, France (1991–2002).

Subjects

200 subjects aged 69 y with information on RBC FAs, plasma Se and completed food frequency questionnaires.

Methods

We examined correlations between the most abundant FAs, Se and number of fish meals per week. Linear regression models were used.

Results

Plasma Se was negatively correlated with RBC 6 poly-unsaturated FA (PUFAs) and positively with 3 PUFAs. Plasma Se, RBC 3 PUFAs, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) increased with fish consumption. Conversely, levels of 6 PUFAs were lower in the highest fish consumption group. All associations between plasma Se and fish consumption remained significant when adjusting for 6 PUFAs alone or additionally for age, sex, education, diabetes, hypertension, dyslipidemia, cardiovascular diseases, and broad food categories (meat, eggs, dairy products, cereals, fruit and vegetable). Associations between 3 PUFAs and fish also remained significant in the same model independently of Se. In linear regression models adjusted for demographic indicators, fish consumption explained only 2.6% of the variance in RBC 3 FAs (6.2% for 6) but as much as 15% of the variance in plasma selenium.

Conclusions

The observed health benefits of fish consumption in the elderly could be related not only to the increase in 3 FA intake but also to other nutrients such as selenium. It is important to consider this observation when interpreting associations between fish consumption and health status in the elderly, particularly with regard to brain function.

Key words

Fish fatty acids selenium 

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Copyright information

© Serdi and Springer Verlag France 2009

Authors and Affiliations

  • Claudine Berr
    • 1
  • T. Akbaraly
    • 1
  • J. Arnaud
    • 2
  • I. Hininger
    • 3
    • 4
  • A.-M. Roussel
    • 3
    • 4
  • P. Barberger Gateau
    • 5
  1. 1.INSERM U888 Pathologies du système nerveux: recherche épidémiologique et cliniqueUniversité Montpellier I. Hôpital La ColombièreMontpellier, Cedex 5France
  2. 2.Département de biologie intégrée. Pôle de BiologieCHU de GrenobleGrenoble, Cedex 9France
  3. 3.INSERMU884GrenobleFrance
  4. 4.LBFAUniversité Joseph FourierGrenoble 1France
  5. 5.INSERM U897Université Bordeaux IIBordeauxFrance

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