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Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease

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Parkinson’s disease (PD) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. Levodopa manages symptoms best, while deep brain stimulation (DBS) is effective for advanced PD patients; however, side effects occur with the diminishing therapeutic window. Recently, Lactiplantibacillus plantarum PS128 (PS128) was found to elevate dopamine levels in rodent brains, suggesting its potential to prevent PD. Here, the therapeutic efficacy of PS128 was examined in the 6-hydroxydopamine rat PD model. Suppression of the power spectral density of beta oscillations (beta PSD) in the primary motor cortex (M1) was recorded as the indicator of disease progression. We found that 6 weeks of daily PS128 supplementation suppressed M1 beta PSD as well as did levodopa and DBS. Long-term normalization of M1 beta PSD was found in PS128-fed rats, whereas levodopa and DBS showed only temporal effects. PS128 + levodopa and PS128 + DBS exhibited better therapeutic effects than did levodopa + DBS or either alone. Significantly improved motor functions in PS128-fed rats were correlated with normalization of M1 beta PSD. Brain tissue analyses further demonstrated the role of PS128 in dopaminergic neuroprotection and the enhanced availability of neurotransmitters. These findings suggest that psychobiotic PS128 might be used alongside conventional therapies to treat PD patients.

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Data Availability

The data presented in this study are available on request from the corresponding author.


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We thank Bened Biomedical Co., Ltd. for providing PS128 used in this study. We also appreciate EzInstrument Technology Co., Ltd. for providing electrophysiology instruments and technical support.


This work was supported by Bened Biomedical Co., Ltd. The funding source had no contribution to the study design, analysis, interpretation of the data, or writing of the report for publication.

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Authors and Affiliations



Conceptualization, SRY and YCT; data curation, YFM and YAL; formal analysis, YFM, SW and YAL; investigation, YFM and YAL; methodology, YFM, YAL, CLH, SW, and SRY; project administration, YFM and CCH; resources, CCH, SRY, and YCT; supervision, SRY and YCT; writing — original draft, YFM; writing — review and editing, YFM, SW, SRY, and YCT. All authors have read and agreed to the published version of the manuscript.

Corresponding authors

Correspondence to Sabrina Wang, Shih-Rung Yeh or Ying-Chieh Tsai.

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Conflict of Interest

CLH and CCH were employed by Bened Biomedical Co., Ltd. at the time of the study. YCT owns stock of Bened Biomedical Co., Ltd. None of the other authors had a personal or financial conflict of interest.

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Ma, YF., Lin, YA., Huang, CL. et al. Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease. Probiotics & Antimicro. Prot. 15, 312–325 (2023).

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