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Gut Microbiota and IL-17A: Physiological and Pathological Responses

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Abstract

IL-17A is a cytokine which is produced by several immune and non-immune cells. The cytokine plays dual roles from protection from microbes and protection from pro-inflammatory based diseases to induction of the pro-inflammatory based diseases. The main mechanisms which lead to the controversial roles of IL-17A are yet to be clarified. Gut microbiota (GM) are the resident probiotic bacteria in the gastrointestinal tracts which have been introduced as a plausible regulator of IL-17A production and functions. This review article describes the recent information regarding the roles played by GM in determination of IL-17A functions outcome.

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Authors and Affiliations

  1. Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran

    Banafsheh Douzandeh-Mobarrez & Ashraf Kariminik

  2. Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

    Banafsheh Douzandeh-Mobarrez

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Douzandeh-Mobarrez, B., Kariminik, A. Gut Microbiota and IL-17A: Physiological and Pathological Responses. Probiotics & Antimicro. Prot. 11, 1–10 (2019). https://doi.org/10.1007/s12602-017-9329-z

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