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Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? A Systematic Review

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Abstract

This study assessed the effectiveness of presybiotics, prosybiotics and synbiotics on reducing serum oxidative stress parameters. PubMed/Medline, Ovid, Google Scholar, ISI Web of Science and SCOPUS were searched up to September 2016. English language randomized clinical trials reporting the effect of presybiotics, prosybiotics or synbiotic interventions on serum oxidative stress parameters in human adults were included. Twenty-one randomized clinical trials met the inclusion criteria for systematic review. Two studies investigated prebiotics, four studies synbiotics and fifteen studies probiotics. According to our systematic review, prebiotic could decrease malondialdehyde and increase superoxidative dismutase, but evidence is not enough. In comparison with fructo-oligosaccharide, inulin is much more useful for oxidative stress reduction. Using probiotics with dairy products could reduce oxidative stress significantly, but probiotic in form of supplementation did not have any effect on oxidative stress. There is limited but supportive evidence that presybiotics, prosybiotics and synbiotics are effective for reducing oxidative stress parameters. Further randomized clinical trials with longer duration of intervention especially on population with increased oxidative stress are needed to provide more definitive results before any recommendation for clinical use of these interventions.

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Acknowledgments

We are extremely grateful to the data collection team at Isfahan University of Medical Sciences.

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Authors and Affiliations

  1. Nutrition and Food Security Research Center, Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Amin Salehi-Abargouei

  2. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

    Reza Ghiasvand

  3. Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Reza Ghiasvand

  4. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran

    Mitra Hariri

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  1. Amin Salehi-Abargouei
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  3. Mitra Hariri
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Correspondence to Mitra Hariri.

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Salehi-Abargouei, A., Ghiasvand, R. & Hariri, M. Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? A Systematic Review. Probiotics & Antimicro. Prot. 9, 1–11 (2017). https://doi.org/10.1007/s12602-016-9248-4

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