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Membrane-Active Peptides from Marine Organisms—Antimicrobials, Cell-Penetrating Peptides and Peptide Toxins: Applications and Prospects

Probiotics and Antimicrobial Proteins volume 7, pages 75–89 (2015)Cite this article

Abstract

Marine organisms are known to be a rich and unique source of bioactive compounds as they are exposed to extreme conditions in the oceans. The present study is an attempt to briefly describe some of the important membrane-active peptides (MAPs) such as antimicrobial peptides (AMPs), cell-penetrating peptides (CPPs) and peptide toxins from marine organisms. Since both AMPs and CPPs play a role in membrane perturbation and exhibit interchangeable role, they can speculatively fall under the broad umbrella of MAPs. The study focuses on the structural and functional characteristics of different classes of marine MAPs. Further, AMPs are considered as a potential remedy to antibiotic resistance acquired by several pathogens. Peptides from marine organisms show novel post-translational modifications such as cysteine knots, halogenation and histidino–alanine bridge that enable these peptides to withstand harsh marine environmental conditions. These unusual modifications of AMPs from marine organisms are expected to increase their half-life in living systems, contributing to their increased bioavailability and stability when administered as drug in in vivo systems. Apart from AMPs, marine toxins with membrane-perturbing properties could be essentially investigated for their cytotoxic effect on various pathogens and their cell-penetrating activity across various mammalian cells. The current review will help in identifying the MAPs from marine organisms with crucial post-translational modifications that can be used as template for designing novel therapeutic agents and drug-delivery vehicles for treatment of human diseases.

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Acknowledgments

NP, DPB and BKY are thankful to University Grants Commission, India, Indian Council of Medical Research, India, Council of Scientific and Industrial Research, India, respectively, for the award of Junior/Senior Research Fellowship.

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The author’s declares that they have no conflict of interest.

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  1. Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, 110016, India

    Nisha Ponnappan, Deepthi Poornima Budagavi, Bhoopesh Kumar Yadav & Archana Chugh

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  1. Nisha Ponnappan
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  2. Deepthi Poornima Budagavi
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  3. Bhoopesh Kumar Yadav
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  4. Archana Chugh
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Correspondence to Archana Chugh.

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Nisha Ponnappan and Deepthi Poornima Budagavi have contributed equally to this work.

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Ponnappan, N., Budagavi, D.P., Yadav, B.K. et al. Membrane-Active Peptides from Marine Organisms—Antimicrobials, Cell-Penetrating Peptides and Peptide Toxins: Applications and Prospects. Probiotics & Antimicro. Prot. 7, 75–89 (2015). https://doi.org/10.1007/s12602-014-9182-2

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Keywords

  • Bioactive peptides
  • Drug delivery
  • Drug discovery
  • Marine biodiversity
  • Peptide-based therapeutics