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Antimicrobial Activity of Bacillus amyloliquefaciens ANT1 Toward Pathogenic Bacteria and Mold: Effects on Biofilm Formation

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Abstract

The intensive use and misuse of antibiotics over the last decades have generated a strong selective pressure for the emergence of multi-resistant strains and nosocomial infections. Biofilm has been demonstrated as a key parameter in spreading infections, especially in hospitals and healthcare units. Therefore, the development of novel anti-biofilm drugs is actually of the upmost importance. Here, the antimicrobial and antibiofilm activities toward pathogenic microorganisms of a set of non-ribosomal synthesized peptides and polyketides isolated from Bacillus amyloliquefaciens ANT1 culture supernatant are presented.

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Acknowledgments

The authors gratefully thank R. Gesuele, L. Lista and A. Zanfardino for their kind help and advice. A. Arguelles-Arias is recipient of a FRIA fellowship (Belgium).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Sciences for the Environment, University Parthenope of Naples, Centro Direzionale Isola C4, 80143, Naples, Italy

    Rosa Anna Nastro

  2. Unité de Biotechnologies et Bioprocédés, Université Libre de Bruxelles, Av F.-D. Roosevelt, 50, CP165/61, 1050, Brussels, Belgium

    Patrick Fickers

  3. Centre d’Ingenierie des Proteines, Bacterial Physiology and Genetics, Allée de la chimie, Université de Liège, Bat. B6, 4000, Liège, Belgium

    Anthony Arguelles-Arias

  4. Unité de Bio-Industrie, Gembloux Agro-Bio Tech, Université de Liège, Passage des Déportés, 5030, Gembloux, Belgium

    Marc Ongena

  5. Department of Biology, University Federico II of Naples, Complesso Universitario di Monte Sant’Angelo, Via Cinthia 5, 80126, Naples, Italy

    Amelia Di Costanzo

  6. Department of Chemical Sciences, University Federico II of Naples, Complesso Universitario di Monte Sant’Angelo, Ed.4, Via Cinthia 5, 80126, Naples, Italy

    Marco Trifuoggi

  7. Department of Biology, University Federico II of Naples, Complesso Universitario di Monte Sant’Angelo, Ed.7, Via Cinthia 5, 80126, Naples, Italy

    Marco Guida

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  1. Rosa Anna Nastro
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  2. Anthony Arguelles-Arias
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  3. Marc Ongena
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  4. Amelia Di Costanzo
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  5. Marco Trifuoggi
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  6. Marco Guida
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  7. Patrick Fickers
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Correspondence to Marco Guida or Patrick Fickers.

Additional information

Rosa Anna Nastro and Anthony Arguelles-Arias contributed equally to this work.

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Nastro, R.A., Arguelles-Arias, A., Ongena, M. et al. Antimicrobial Activity of Bacillus amyloliquefaciens ANT1 Toward Pathogenic Bacteria and Mold: Effects on Biofilm Formation. Probiotics & Antimicro. Prot. 5, 252–258 (2013). https://doi.org/10.1007/s12602-013-9143-1

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