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Proceedings of the Zoological Society

, Volume 71, Issue 1, pp 48–55 | Cite as

Association of Endogenous Testosterone with Lipid and Blood Glucose Profiles in Elderly Men with Angiographically Proven Cardiovascular Disease of Nadia and Murshidabad District, West Bengal

  • Piyali Chowdhury
  • Koushik Sen
  • Shreyasi Gupta
  • Suravi Majumder
  • Payel Guha
  • Arindam Chakraborty
  • Amar K. Chandra
  • Dilip Mukherjee
Research Article

Abstract

Testosterone is commonly known for its role in the regulation of reproductive physiology in men. Epidemiologic studies suggest that endogenous testosterone levels may be implicated in cardiovascular diseases (CVDs). Our study aimed to investigate the relationship between serum total testosterone (TT) levels and lipid profile as well as fasting blood glucose (FBG) levels in male patients ranging from 40 to 70 years old with angiographically proven CVDs from Nadia and Murshidabad district of West Bengal, India. These data were compared with the normal men with no CVD history. We observed a significantly low serum TT levels in CVD patient group compared to the normal group. Among CVD patients, a significant (p < 0.05) negative association was found between serum TT and total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein, whereas a significant positive correlation (p < 0.05) was found between serum TT and high density lipoprotein. We also observed a highly significant negative correlation between TT and FBG levels in CVD patient group. Thus, in these two densely populated district of West Bengal with poor socio-economic condition, low levels of serum TT in elderly men is associated with CVD that appear together with an atherogenic lipid milieu that may be involved in the pathogenesis of CVD. Results further indicate that low serum TT might have a role in the development of hyperglycemia as evidenced from high FBG level in elderly men.

Keywords

Testosterone Cardiovascular disease (CVD) Lipids Glucose Elderly men 

Notes

Acknowledgments

The authors are thankful to Dr. Gordon Niswender, Colorado State University, Fort Collins, USA for his generous gift of T antibody.

Funding

This work is supported in part by Personal Research Grant and DST-PURSE grant of Kalyani University to Prof. Dilip Mukherjee.

Compliance with Ethical Standards

Conflict of interest

The authors declared that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

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Copyright information

© Zoological Society, Kolkata, India 2016

Authors and Affiliations

  • Piyali Chowdhury
    • 1
  • Koushik Sen
    • 1
  • Shreyasi Gupta
    • 1
  • Suravi Majumder
    • 1
  • Payel Guha
    • 1
  • Arindam Chakraborty
    • 1
  • Amar K. Chandra
    • 2
  • Dilip Mukherjee
    • 1
  1. 1.Endocrinology Laboratory, Department of ZoologyUniversity of KalyaniKalyaniIndia
  2. 2.Department of PhysiologyUniversity of CalcuttaKolkataIndia

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