Does patchouli oil change blood platelet monoamine oxidase-A activity of adult mammals?
Patchouli oil, an essential aroma oil extracted from patchouli leaf during short-term exposure with five and ten drops either inhibited (at 1 or 2 h) or stimulated (at 4 h) the platelet MAO-A activity depending on the dosages of the aroma oil mainly due to inhibition or stimulation of its K m. The long-term 15 consecutive days exposure (with two or five drops) of patchouli oil, on the other hand, maximally stimulated the platelet MAO-A activity with five drops patchouli oil for 1 h exposure, but further continuation of its exposure with same doses (two or five drops) for 30 consecutive days significantly stimulated (with two drops) and inhibited (with five drops) the platelet MAO-A activity due to stimulation and inhibition respectively of its corresponding both K m and V max. These results thus suggest that this aroma oil exposure may modulate the blood platelet serotonergic regulation depending on the dose, duration, and conditions of exposure.
KeywordsBlood platelet Monoamine oxidase-A Patchouli oil
The authors are thankful to Prof. S. Sengupta, Department of Statistics, University of Calcutta for his kind help in statistical analysis of the data. We are also thankful to the University of Calcutta, Kolkata, India, the Indian Council of Medical Research, New Delhi, India, University Grants Commission, New Delhi, India for their financial help.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
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