BDNF levels are increased in peripheral blood of middle-aged amateur runners with no changes on histone H4 acetylation levels
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Our aim was to compare the basal levels of plasma brain-derived neurotrophic factor (BDNF) and global histone H4 acetylation in peripheral blood mononuclear cells (PBMCs) of healthy amateur runners (EXE group) with sedentary individuals (SED group) as well as to investigate the acute effect of a running race on these markers in the EXE group. Five days before the race, all participants were submitted to a basal blood collection. On the race day, two blood samples were collected in the EXE group before the running started and immediately at the end. In the basal period, a significant increase of plasma BDNF levels in the EXE individuals when compared to the SED group (p = 0.036) was demonstrated, while no difference in global histone H4 acetylation levels was observed. These parameters were unaltered in the EXE group after the race. The increased levels of BDNF might be linked to healthy middle-aged runners’ phenotype.
KeywordsExercise Epigenetic Neurotrophins Adult men Plasma Peripheral blood mononuclear cells (PBMCs)
This work was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq/Brazil; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)/Brazil and Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS)/Brazil.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
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