Early-life stress increases the motility of microglia in adulthood
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Early-life stress may cause several neuropsychological disorders in adulthood. Such disorders may be induced as a result of instability of neuronal circuits and/or synaptic formation. However, the mechanisms underlying such instability have not yet been clearly understood. We previously reported that the mushroom spine in the somatosensory cortex (SSC) is unstable in early-life stressed mice not only in the juvenile stage but also in adulthood. In this study, we measured the number and motility of microglial processes in early-life stressed mice to understand the mechanism further. We found that the number and motility of filopodia-like protrusions of microglial processes tended to increase in the SSC of early-life stressed mice. Interestingly, the motility of protrusions correlated significantly with the nociceptive threshold level measured by the von Frey test. These results indicated that the activity of microglia affected the neuronal function in early-life stressed mice.
KeywordsMaternal deprivation In vivo imaging In vivo microdialysis Somatosensory cortex
This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (23111504) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) to YT, a Grant-in-Aid for Scientific Research (B) (21390065) from the Japan Society for the Scientific of Sciences (JSPS) to NK, and Core Research for Evolutional Science and Technology from Japan Science and Technology Agency and Grant-in-Aid for Scientific Research (B) (19390055) and (A) (22240042) from the Japan Society for the Scientific of Sciences (JSPS) to JN.
Conflict of interest
There is no conflict of interest in the present study.
- 10.Toya S, Takatsuru Y, Amano I, Koibuchi N (2013) The molecular mechanism of early life stress for synaptic instability in somatosensory cortex. J Physiol Sci 63:S152Google Scholar
- 27.Musazzi L, Milanese M, Farisello P, Zappettini S, Tardito D, Barbiero VS, Bonifacino T, Mallei A, Baldelli P, Racagni G, Raiteri M, Benfenati F, Bonanno G, Popoli M (2010) Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS ONE 5:e8566CrossRefPubMedCentralPubMedGoogle Scholar