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The Journal of Physiological Sciences

, Volume 65, Issue 2, pp 187–194 | Cite as

Early-life stress increases the motility of microglia in adulthood

  • Yusuke Takatsuru
  • Junichi Nabekura
  • Tatsuya Ishikawa
  • Shin-ichi Kohsaka
  • Noriyuki Koibuchi
Original Paper

Abstract

Early-life stress may cause several neuropsychological disorders in adulthood. Such disorders may be induced as a result of instability of neuronal circuits and/or synaptic formation. However, the mechanisms underlying such instability have not yet been clearly understood. We previously reported that the mushroom spine in the somatosensory cortex (SSC) is unstable in early-life stressed mice not only in the juvenile stage but also in adulthood. In this study, we measured the number and motility of microglial processes in early-life stressed mice to understand the mechanism further. We found that the number and motility of filopodia-like protrusions of microglial processes tended to increase in the SSC of early-life stressed mice. Interestingly, the motility of protrusions correlated significantly with the nociceptive threshold level measured by the von Frey test. These results indicated that the activity of microglia affected the neuronal function in early-life stressed mice.

Keywords

Maternal deprivation In vivo imaging In vivo microdialysis Somatosensory cortex 

Notes

Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (23111504) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) to YT, a Grant-in-Aid for Scientific Research (B) (21390065) from the Japan Society for the Scientific of Sciences (JSPS) to NK, and Core Research for Evolutional Science and Technology from Japan Science and Technology Agency and Grant-in-Aid for Scientific Research (B) (19390055) and (A) (22240042) from the Japan Society for the Scientific of Sciences (JSPS) to JN.

Conflict of interest

There is no conflict of interest in the present study.

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Copyright information

© The Physiological Society of Japan and Springer Japan 2015

Authors and Affiliations

  • Yusuke Takatsuru
    • 1
    • 3
  • Junichi Nabekura
    • 2
    • 4
  • Tatsuya Ishikawa
    • 2
    • 3
  • Shin-ichi Kohsaka
    • 5
  • Noriyuki Koibuchi
    • 1
  1. 1.Department of Integrative PhysiologyGunma University Graduate School of MedicineMaebashiJapan
  2. 2.Division of Homeostatic DevelopmentNational Institute for Physiological SciencesOkazakiJapan
  3. 3.CREST, Japan Science and Technology AgencyKawaguchiJapan
  4. 4.The Graduate University for Advanced StudiesHayamaJapan
  5. 5.Department of NeurochemistryNational Institute of NeuroscienceKodairaJapan

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