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The Journal of Physiological Sciences

, Volume 64, Issue 3, pp 185–193 | Cite as

Role of slow delayed rectifying potassium current in dynamics of repolarization and electrical memory in swine ventricles

  • Linyuan Jing
  • Kathleen Brownson
  • Abhijit PatwardhanEmail author
Original Paper

Abstract

Dynamics of repolarization, quantified as restitution and electrical memory, impact conduction stability. Relatively less is known about role of slow delayed rectifying potassium current, I Ks, in dynamics of repolarization and memory compared to the rapidly activating current I Kr. Trans-membrane potentials were recorded from right ventricular tissues from pigs during reduction (chromanol 293B) and increases in I Ks (mefenamic acid). A novel pacing protocol was used to explicitly control diastolic intervals to quantify memory. Restitution hysteresis, a consequence of memory, increased after chromanol 293B (loop thickness and area increased 27 and 38 %) and decreased after mefenamic acid (52 and 53 %). Standard and dynamic restitutions showed an increase in average slope after chromanol 293B and a decrease after mefenamic acid. Increase in slope and memory are hypothesized to have opposite effects on electrical stability; therefore, these results suggest that reduction and enhancement of I Ks likely also have offsetting components that affect stability.

Keywords

Slow delayed rectifier potassium current Restitution Action potential duration Cardiac memory Hysteresis Ventricular arrhythmia 

Abbreviations

IKs

Slow delayed rectifier potassium current

AP

Action potential

IKr

Rapid delayed rectifier potassium current

APD

Action potential duration

CL

Cycle length

DI

Diastolic interval

TMP

Transmembrane potential

TdP

Torsades de Pointes

Notes

Acknowledgement

Supported by grants from the National Science Foundation (0730450, 0814194) and the Commonwealth of Kentucky.

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Copyright information

© The Physiological Society of Japan and Springer Japan 2014

Authors and Affiliations

  • Linyuan Jing
    • 1
  • Kathleen Brownson
    • 1
  • Abhijit Patwardhan
    • 1
    Email author
  1. 1.Department of Biomedical EngineeringUniversity of KentuckyLexingtonUSA

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