Abstract
Background
No relationship between the ratio of peak early velocity of left ventricular inflow to peak systolic longitudinal velocity of the mitral annulus velocity (E/e′) and insulin resistance has yet been shown in patients with cardiac disease. We hypothesized that patients with high E/e′ values would tend not to show the rapid blood glucose-lowering in response to exercise training characteristic of impaired glucose tolerance (IGT) or diabetes mellitus (DM) patients.
Methods
The subjects were continuous IGT/DM patients (n = 27) participating in cardiac rehabilitation. All patients’ E/e′ values were measured by echocardiography. The patients’ blood glucose levels (mg/dl) were measured just before (pre-BS) and after (post-BS) exercise training. Post-BS was subtracted from pre-BS to obtain ΔBS, and the relationship between E/e′ and ΔBS was investigated.
Results
E/e′ correlated negatively with ΔBS. Moreover, E/e′ was a significant predictor of ΔBS and as such was independent of hemoglobin A1c (HbA1c), pre-BS, and presence of atrial fibrillation on multivariate analysis.
Conclusions
Patients with high E/e′, indicating high left ventricular filling pressure, were unlikely to exhibit the rapid glucose-lowering response.
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Fukuda, Y., Yoshimura, K., Fukuda, Y. et al. High E/e′ disrupts the rapid lowering of blood glucose in response to exercise training. J Echocardiogr 10, 119–124 (2012). https://doi.org/10.1007/s12574-012-0134-0
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DOI: https://doi.org/10.1007/s12574-012-0134-0