Abstract
The treatment of unresectable multiple lung metastasis of giant cell tumor of bone (GCTB) is challenging. In the current manuscript, we present a case who presented with multiple lung metastases of GCTB and was successfully managed with the use of denosumab allowing for surgical resection of the metastatic lesions that was previously deemed unresectable. Pathologic examination also clearly demonstrated the histological effects of denosumab. We emphasize on effective response to denosumab even in metastatic GCTB.
Similar content being viewed by others
References
Thomas DM, Skubitz KM (2009) Giant cell tumor of bone. Curr Opin Oncol 21:338–344
Szendroi M (2004) Gian t-cell tumour of bone. J Bone Joint Surg Br 86:5–12
Frank MK, Doris EW, Carrie Y et al (2011) Recurrent giant cell tumor of long bones: analysis of surgical management. In wards. Clin Orthop Relat Res 469(4):1181–1187
Campanacci M, Baldini N, Boriani S et al (1987) Giant-cell tumor of bone. J Bone Joint Surg Am 69:106–114
Thomas D, Henshaw R, Skubitz K et al (2010) Denosumab in patients with giant-cell tumor of bone: an open-label, phase 2 study. Lancet Oncol 11:275–280
Nicole AK, Polgreen LE, Ogilvie C et al (2013) Denosumab treatment of metastatic giant-cell tumor of bone in a 10-year old girl. J Clin Oncol 31:e200–e202
Bekker PJ, Holloway DL, Rasmussen AS et al (2004) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 19:1059–1066
Bullough PG, Bansal M (2002) Malignancy in giant cell tumour. In: Fletcher CDM, Unni K, Mertens F (eds) World Health Organization classification of tumors: pathology and genetics of tumors of soft tissue and bone. International Agency for Research on Cancer (IARC), Lyon
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent
The patient was informed that data from the case would be submitted for publication and gave his consent.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Watanabe, Y., Kaya, M., Sasaki, M. et al. Experience using denosumab for lung metastases of giant cell tumor of bone. Eur Orthop Traumatol 6, 239–241 (2015). https://doi.org/10.1007/s12570-015-0308-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12570-015-0308-0