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Heat shock proteins in total knee arthroplasty. A pilot study

  • Original Article
  • Published:
European Orthopaedics and Traumatology

Abstract

Introduction

Thanks to the development of defense mechanisms, the human body has been able to adapt to adverse environmental conditions causing acute and chronic stress. This adaptive response includes a specific group of proteins called heat shock proteins (Hsps).

Objective

The present study examines the biology of Hsps and other acute phase reactants in patients subjected to uncomplicated total knee arthroplasty as possible biomarkers of surgical inflammatory stress.

Material/methods

A prospective, observational descriptive pilot study with analytical components was carried out, evaluating the acute phase response levels of 20 patients diagnosed with advanced primary gonarthrosis before and after total knee arthroplasty.

Results

Statistically significant changes were recorded in leukocyte count, fibrinogen, erythrocyte sedimentation rate, C-reactive protein (CRP), IL-6, and anti-Hsp70i autoantibodies at the studied timepoints. Serum Hsp70i levels were lower in the immediate postoperative period, followed by recovery. In conclusion, despite a lack of diagnostic specificity, combined measurements of acute phase response levels can be useful in detecting the presence or intensity of systemic inflammatory processes. The circulating anti-Hsp70i values decreased significantly 24 h after surgery, a fact that may reflect immune depression secondary to surgical stress.

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Authors and Affiliations

  1. General University Hospital Gregorio Marañón, Madrid, Spain

    Francisco Chana, M. Concepcion Guisasola, Manuel J. Villanueva, Julio de las Heras, Jose Antonio Calvo & Javier Vaquero

Authors
  1. Francisco Chana
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  2. M. Concepcion Guisasola
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  3. Manuel J. Villanueva
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  4. Julio de las Heras
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  5. Jose Antonio Calvo
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  6. Javier Vaquero
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Correspondence to Francisco Chana.

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Chana, F., Guisasola, M.C., Villanueva, M.J. et al. Heat shock proteins in total knee arthroplasty. A pilot study. Eur Orthop Traumatol 1, 119–124 (2010). https://doi.org/10.1007/s12570-010-0026-6

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  • DOI: https://doi.org/10.1007/s12570-010-0026-6

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