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Acrosome markers of human sperm

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Abstract

Molecular biomarkers that can assess sperm acrosome status are very useful for evaluating sperm quality in the field of assisted reproductive technology. In this review, we introduce and discuss the localization and function of acrosomal proteins that have been well studied. Journal databases were searched using keywords, including “human acrosome”, “localization”, “fertilization-related protein”, “acrosomal membrane”, “acrosomal matrix”, “acrosome reaction”, “knockout mouse”, and “acrosome marker”.

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Acknowledgments

The authors would like to thank T. Mutoh, K Ushikoshi, A Tajima, and T Kanamori for their excellent technical assistance. This work is supported by a Grant from the Japan Society for the Promotion of Science in part to C. I. (15K10638), K. T. (25293041) and CREST, Japan Science and Technology Agency.

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  1. Department of Reproductive Biology and Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan

    Chizuru Ito & Kiyotaka Toshimori

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  1. Chizuru Ito
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  2. Kiyotaka Toshimori
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Correspondence to Chizuru Ito.

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Ito, C., Toshimori, K. Acrosome markers of human sperm. Anat Sci Int 91, 128–142 (2016). https://doi.org/10.1007/s12565-015-0323-9

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