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Adult leptomeningeal cerebellar heterotopia in contact with the posterior inferior cerebellar artery

Abstract

A leptomeningeal mass was encountered during microdissection of a 63-year-old male cadaver, located dorsal to the left side of the medulla oblongata. The structure was compressing the posterior inferior cerebellar artery (PICA) and was composed of cerebellar-like tissue. Immunohistochemistry for S100 protein, glial fibrillary acidic protein and neurofilaments (NF, the triplet proteins and the 200 kD antibody) on paraffin-embedded samples confirmed the cerebellar heterotopion. Abundant Lewy-like degenerative bodies were also identified within the heterotopion; they were positive for the NF triplet and negative for the 200 kD neurofilaments. Purkinje cells were rare. This is the first evidence of a leptomeningeal cerebellar heterotopia in contact with PICA in adult. Such subtentorial heterotopias, even if rare, should be searched for during clinical, paraclinical and surgical explorations of the posterior fossa.

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References

  1. Billings KJ, Danziger FS (1973) Cerebellar heterotopia. Case report. J Neurosurg 38:218–220

    PubMed  Article  CAS  Google Scholar 

  2. Chang AH, Kaufmann WE, Brat DJ (2001) Ectopic cerebellum presenting as a suprasellar mass in infancy: implications for cerebellar development. Pediatr Dev Pathol 4:89–93

    PubMed  Article  CAS  Google Scholar 

  3. Farhat SM, Hudson JS (1969) Extracerebral brain heterotopia. Case report. J Neurosurg 30:190–194

    PubMed  Article  CAS  Google Scholar 

  4. Goldman JE, Yen SH, Chiu FC, Peress NS (1983) Lewy bodies of Parkinson’s disease contain neurofilament antigens. Science 221:1082–1084

    PubMed  Article  CAS  Google Scholar 

  5. Guibaud L, Devonec S, Desportes V, Roth P, Gaucherand P, Pracros JP (2005) Extracerebellar ectopic brain tissue in the posterior fossa. Ultrasound Obstet Gynecol 26:687–689

    PubMed  Article  CAS  Google Scholar 

  6. Hill WD, Arai M, Cohen JA, Trojanowski JQ (1993) Neurofilament mRNA is reduced in Parkinson’s disease substantia nigra pars compacta neurons. J Comp Neurol 329:328–336

    PubMed  Article  CAS  Google Scholar 

  7. Marubayashi T, Matsukado Y (1978) Intracranial extracerebral brain heterotopia. Case report. J Neurosurg 48:470–474

    PubMed  Article  CAS  Google Scholar 

  8. Muzumdar D, Michaud J, Ventureyra EC (2006) Anterior cranial base glioneuronal heterotopia. Childs Nerv Syst 22:227–233

    PubMed  Article  Google Scholar 

  9. Nishio S, Mizuno J, Barrow DL, Takei Y, O’Brien MS (1988) Intracranial extracerebral glioneural heterotopia. Childs Nerv Syst 4:244–248

    PubMed  Article  CAS  Google Scholar 

  10. Oya S, Kawahara N, Aoki S et al (2005) Intracranial extracerebral glioneuronal heterotopia. Case report and review of the literature. J Neurosurg 102:105–112

    PubMed  Google Scholar 

  11. Ozgen B, Oguz KK, Canyigit M, Mocan MC, Irkec M (2007) Intracranial extracerebral glioneuronal heterotopia with fetal laminar organization on MR imaging. Pediatr Radiol 37:717–719

    PubMed  Article  Google Scholar 

  12. Patel S, Barkovich AJ (2002) Analysis and classification of cerebellar malformations. Am J Neuroradiol 23:1074–1087

    PubMed  Google Scholar 

  13. Wakai S, Nakamura K, Arai T, Nagai M (1983) Extracerebral neural tissue mass in the middle cranial fossa extending into the oropharynx in a neonate. Case report. J Neurosurg 59:692–696

    PubMed  Article  CAS  Google Scholar 

  14. Walsh L (2003) Congenital malformations of the human brainstem. Semin Pediatr Neurol 10:241–251

    PubMed  Article  Google Scholar 

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Acknowledgments

This study was supported by the Sectoral Operational Programme Human Resources Development (SOP HRD), financed by the European Social Fund and by the Romanian Government under contract number POSDRU/89/1.5/S/64153.

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Correspondence to Mugurel Constantin Rusu.

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Rusu, M.C. Adult leptomeningeal cerebellar heterotopia in contact with the posterior inferior cerebellar artery. Anat Sci Int 88, 101–105 (2013). https://doi.org/10.1007/s12565-012-0138-x

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Keywords

  • Lewy body
  • Posterior cranial fossa
  • Vertebral artery
  • Accessory nerve
  • Brainstem