Abstract
When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even synergistic effect can be realized. Combination treatment regimens are aimed at increasing the efficiency and, above all, at the complete eradication of the tumor, which can be achieved either by suppressing the survival mechanisms in PDT-resistant tumor cells or by pre-attenuation of tumor cells so that they become more susceptible to subsequent PDT. Photodynamic therapy is an approved medical technology for the treatment of various malignant neoplasms, and several precancerous and non-cancer diseases. To date, numerous data have been published on the combined use of PDT with traditional and innovative methods of treatment. This review considers research in this area in recent years.
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Funding
This work was carried out with the financial support of the Ministry of Science and Higher Education of the Russian Federation (project № 0706-2020-0019), the Russian Foundation for Basic Research (№ 20-33-90289), and the Russian Science Foundation (№ 21-13-00078).
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Ostroverkhov Petr Vasilievich, Popov Alexander Alexandrovich, Kirin Nikita Sergeevich, Pogorilyy Viktor Alexeyevich, and Suvorov Nikita Vladimirovich. The article sections had been written by the following authors: Abstract, Introduction, and Conclusion (Grin Mikhail Alexandrovich, Filonenko Elena Vyacheslavovna); Combined chemotherapy and PDT for cancer treatment (Pogorilyy Viktor Alexeyevich, Suvorov Nikita Vladimirovich); Combination of PDT and surgery (Kirin Nikita Sergeevich); Combination of PDT and radiation therapy (Anna Igorevna Sazonova); Combination of PDT with radionuclide therapy and diagnostics (Popov Alexander Alexandrovich); Nanoparticles for co-delivery of chemotherapeutic drugs and photosensitizers (Ostroverkhov Petr Vasilievich); and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Grin, M., Suvorov, N., Ostroverkhov, P. et al. Advantages of combined photodynamic therapy in the treatment of oncological diseases. Biophys Rev 14, 941–963 (2022). https://doi.org/10.1007/s12551-022-00962-6
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DOI: https://doi.org/10.1007/s12551-022-00962-6