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Tensile and compressive force regulation on cell mechanosensing

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Abstract

Receptor-mediated cell mechanosensing plays critical roles in cell spreading, migration, growth, and survival. Dynamic force spectroscopy (DFS) techniques have recently been advanced to visualize such processes, which allow the concurrent examination of molecular binding dynamics and cellular response to mechanical stimuli on single living cells. Notably, the live-cell DFS is able to manipulate the force “waveforms” such as tensile versus compressive, ramped versus clamped, static versus dynamic, and short versus long lasting forces, thereby deriving correlations of cellular responses with ligand binding kinetics and mechanical stimulation profiles. Here, by differentiating extracellular mechanical stimulations into two major categories, tensile force and compressive force, we review the latest findings on receptor-mediated mechanosensing mechanisms that are discovered by the state-of-the-art live-cell DFS technologies.

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Abbreviations

DFS:

Dynamic force spectroscopy

AFM:

Atomic force microscopy

BFP:

Biomembrane force probe

OT:

Optical tweezers

TCR:

T cell receptor

pMHC:

Peptide major histocompatibility complex

VWF:

von Willebrand factor

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Acknowledgments

We thank Prof. Cheng Zhu for helpful discussion. This work was supported by the Cardiac Society of Australia and New Zealand BAYER Young Investigator Research Grant (L.A.J.). L.A.J. is an Australian Research Council DECRA Fellow (DE190100609) and a former National Heart Foundation of Australia postdoctoral fellow (101798). Y.C. is a MERU (Medolago-Ruggeri) Foundation post-doctoral awardee. Z.L. is an Australian Research Council Future Fellow (FT140101152).

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Author notes

  1. Yunfeng Chen and Lining Arnold Ju contributed equally to this work.

Authors and Affiliations

  1. Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA

    Yunfeng Chen

  2. School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD, 4000, Australia

    Zhiyong Li

  3. Heart Research Institute, Sydney, Australia

    Lining Arnold Ju

  4. School of Aerospace, Mechanical and Mechatronic Engineering, Darlington, Australia

    Lining Arnold Ju

  5. Charles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia

    Lining Arnold Ju

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  1. Yunfeng Chen
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Correspondence to Lining Arnold Ju.

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Yunfeng Chen declares that he has no conflict of interest. Zhiyong Li declares that he has no conflict of interest. Lining Arnold Ju declares that he has no conflict of interest.

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This article is part of a Special Issue dedicated to the “2018 Joint Conference of the Asian Biophysics Association and Australian Society for Biophysics” edited by Kuniaki Nagayama, Raymond Norton, Kyeong Kyu Kim, Hiroyuki Noji, Till Böcking, and Andrew Battle.

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Chen, Y., Li, Z. & Ju, L.A. Tensile and compressive force regulation on cell mechanosensing. Biophys Rev 11, 311–318 (2019). https://doi.org/10.1007/s12551-019-00536-z

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