Epigenetic influences on genetically triggered thoracic aortic aneurysm
Genetically triggered thoracic aortic aneurysms (TAAs) account for 30% of all TAAs and can result in early morbidity and mortality in affected individuals. Epigenetic factors are now recognised to influence the phenotype of many genetically triggered conditions and have become an area of interest because of the potential for therapeutic manipulation. Major epigenetic modulators include DNA methylation, histone modification and non-coding RNA. This review examines epigenetic modulators that have been significantly associated with genetically triggered TAAs and their potential utility for translation to clinical practice.
KeywordsThoracic aortic aneurysm Aortic dilatation Epigenetics Non-coding RNA MicroRNA
The authors would like to thank Morvarid Emami for providing the histology images.
Compliance with ethical standards
Conflict of interest
Stefanie Portelli declares that she has no conflict of interest. Elizabeth Robertson declares that she has no conflict of interest. Cassandra Malecki declares that she has no conflict of interest. Kiersten Liddy declares that she has no conflict of interest. Brett Hambly declares that he has no conflict of interest. Richmond Jeremy declares that he has no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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