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Designing tailored microbial and enzymatic response in ionic liquids for lignocellulosic biorefineries

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References

  • Burney PR, Nordwald EM, Hickman K, Kaar JL, Pfaendtner J (2015) Molecular dynamics investigation of the ionic liquid/enzyme interface: application to engineering enzyme surface charge. Proteins 83:670–680

    Article  CAS  PubMed  Google Scholar 

  • Cruz AG, Scullin C, Mu C, Cheng G, Stavila V, Varanasi P, Mentel J, Xu DY, Chung YA, Simmons BA, Singh S (2013) Impact of high biomass loading on ionic liquid pretreatment. Biotechnology for Biofuels 6:52

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dadi AP, Varanasi S, Schall CA (2006) Enhancement of cellulose saccharification kinetics using an ionic liquid pretreatment step. Biotechnol Bioeng 95(5):904–910

    Article  CAS  PubMed  Google Scholar 

  • Datta S, Holmes B, Park JI, Chen Z, Dibble DC, Hadi M, Blanch HW, Simmons BA, Sapra R (2010) Ionic liquid tolerant hyperthermophilic cellulases for biomass pretreatment and hydrolysis. Green Chem 2010(12):338–345

    Article  Google Scholar 

  • Johnson L, Park S, Gintner L, Snow CD (2016) J Mol Catal B Enzym 132:84–90

    Article  CAS  Google Scholar 

  • Khudyakov JI, D’haeseleer P, Borglin SE, DeAngelis KM, Woo H, Lindquist EA, Hazen TC, Simmons BA, Thelen MP (2012) Global transcriptome response to ionic liquid by a tropical rain forest soil bacterium, Enterobacter lignolyticus SCF1. Proc Natl Acad Sci 109(32):E2173–E2182

    Article  CAS  PubMed  Google Scholar 

  • Konda M, Shi J, Singh S, Blanch HW, Simmons BA, Klein-Marcuschamer D (2014) Understanding cost drivers and economic potential of two variants of ionic liquid pretreatment for cellulosic biofuel production. Biotechnology for Biofuels 7:86

    Article  PubMed  PubMed Central  Google Scholar 

  • Le Crom S, Schackwitz W, Pennacchio L, Magnuson JK, Culley DE, Collett JR, Martin J, Druzhinina IS, Mathis H, Monot F, Seiboth B, Cherry B, Rey M, Berka R, Kubicek CP, Baker SE, Margeot A (2009) Tracking the roots of cellulase hyperproduction by the fungus Trichoderma reesei using massively parallel DNA sequencing. Proc Natl Acad Sci 106(38):16151–16156

    Article  PubMed  Google Scholar 

  • Li C, Knierim B, Manisseri C, Scheller HV, Vogel K, Simmons B, Singh S (2010) Comparison of dilute acid and ionic liquid pretreatment of switchgrass: biomass recalcitrance, delignification and enzymatic saccharification. Bioresour Technol 101(13):4900–4906

    Article  CAS  PubMed  Google Scholar 

  • Nancharaiah YV, Francis AJ (2011) Alkyl-methylimidazolium ionic liquids affect the growth and fermentative metabolism of Clostridium sp. Bioresour Technol 102(11):6573–6578

    Article  PubMed  Google Scholar 

  • Nordwald EM, Kaar JL (2013) Stabilization of enzymes in ionic liquids via modification of enzyme charge. Biotechnol Bioeng 110(9):2352–2360

  • Nordwald EM, Brunecky R, Himmel ME, Beckham GT, Kaar JL (2014) Charge engineering of cellulases improves ionic liquid tolerance and reduces lignin inhibition. Biotechnol Bioeng 111(8):1541–1549

  • Petkovic M, Ferguson J, Bohn A, Trindade J, Martins I, Carvalho MB, Leitao MC, Rodrigues C, Garcia H, Ferreira R, Seddon KR, Rebelo LPN, Pereira CS (2009) Exploring fungal activity in the presence of ionic liquids. Green Chem 11:889–894

    Article  CAS  Google Scholar 

  • Ragauskas AJ, Williams CK, Davison BH, Britovsek G, Cairney J, Eckert CA, Frederick WJ, Hallett JP, Leak DJ, Liotta CL, Mielenz JR, Murphy R, Templer R, Tschaplinski T (2006) The path forward for biofuels and biomaterials. Science 27 311(5760):484–489

    CAS  Google Scholar 

  • Remsing RC, Swatloski RP, Rogers RD, Moyna G (2006) Mechanism of cellulose dissolution in the ionic liquid 1-n-butyl-3-methylimidazolium chloride: a 13 C and 35/37 Cl NMR relaxation study on model systems. Chem Commun 12:1271–1273

  • Rüegg TL, Kim EM, Simmons BA, Keasling JD, Singer SW, Lee TS, Thelen MP (2014) An auto-inducible mechanism for ionic liquid resistance in microbial biofuel production. Nat Commun 5:3490

    Article  PubMed  Google Scholar 

  • Singh S, Simmons BA, Vogel KP (2009) Visualization of biomass solubilization and cellulose regeneration during ionic liquid pretreatment of switchgrass. Biotechnol Bioeng 104(1):68–75

  • Socha AM, Parthasarathi R, Shi J, Pattathil S, Whyte D, Bergeron M, Venkatachalam S, George A, Hahn MG, Simmons BA, Singh S (2014) Efficient biomass pretreatment using ionic liquids derived from lignin and hemicellulose. Proc Natl Acad Sci 111(35):E3587–E3595

    Article  CAS  PubMed  Google Scholar 

  • Summers SR, Sprenger KG, Pfaendtner J, Marchant J, Summers MF, Kaar JL (2017) Mechanism of competitive inhibition and destabilization of Acidothermus cellulolyticus Endoglucanase 1 by ionic liquids. J. Phys. Chem. B, 121, 10,793–10,803.

    Article  CAS  Google Scholar 

  • Sun J, Shi J, Konda M, Campos D, Liu D, Nemser S, Shamshina J, Dutta T, Berton P, Gurau G, Rogers RD, Simmons BA, Singh S (2017) Efficient dehydration and recovery of ionic liquid after lignocellulosic processing using pervaporation. Biotechnology for Biofuels 10:154

    Article  PubMed  PubMed Central  Google Scholar 

  • Wolski PW, Dana CM, Clark DS, Blanch HW (2016) Engineering ionic liquid-tolerant cellulases for biofuels production. Protein Engineering, Design & Selection 29(4):117–122

    Article  CAS  Google Scholar 

  • Wu YW, Higgins B, Yu C, Reddy AP, Ceballos S, Joh LD, Simmons BA, Singer SW, VanderGheynst JS (2016) Ionic liquids impact the bioenergy feedstock-degrading microbiome and transcription of enzymes relevant to polysaccharide hydrolysis. Applied and Environmental Science 1(6):e00120–e00116

    Google Scholar 

  • Xu F, Sun J, Konda M, Shi J, Dutta T, Scown CD, Simmons BA, Singh S (2015) Transforming biomass conversion with ionic liquids: process intensification and the development of a high-gravity, one-pot process for the production of cellulosic ethanol. Energy Environ Sci. https://doi.org/10.1039/C5EE02940F

  • Xu J, Sheng Z, Wang X, Liu X, Xia J, Xiong P, He B (2016) Enhancement in ionic liquid tolerance of cellulase immobilized on PEGylated graphene oxide nanosheets: application in saccharification of lignocellulose. Bioresource Technol 200:1060–1064

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Sandia National Laboratories, Livermore, CA, 94551, USA

    Seema Singh

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  1. Seema Singh
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Correspondence to Seema Singh.

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Seema Singh declares that she has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by the author.

Additional information

This article is part of a Special Issue on ‘Ionic Liquids and Biomolecules’ edited by Antonio Benedetto and Hans-Joachim Galla.

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Singh, S. Designing tailored microbial and enzymatic response in ionic liquids for lignocellulosic biorefineries. Biophys Rev 10, 911–913 (2018). https://doi.org/10.1007/s12551-018-0418-3

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  • DOI: https://doi.org/10.1007/s12551-018-0418-3

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