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Biophysical Reviews

, Volume 10, Issue 2, pp 677–686 | Cite as

Structural atlas of dynein motors at atomic resolution

  • Akiyuki Toda
  • Hideaki Tanaka
  • Genji Kurisu
Review

Abstract

Dynein motors are biologically important bio-nanomachines, and many atomic resolution structures of cytoplasmic dynein components from different organisms have been analyzed by X-ray crystallography, cryo-EM, and NMR spectroscopy. This review provides a historical perspective of structural studies of cytoplasmic and axonemal dynein including accessory proteins. We describe representative structural studies of every component of dynein and summarize them as a structural atlas that classifies the cytoplasmic and axonemal dyneins. Based on our review of all dynein structures in the Protein Data Bank, we raise two important points for understanding the two types of dynein motor and discuss the potential prospects of future structural studies.

Keywords

Dynein Dynein subunits Axonemal dynein light chain-1 Molecular motor Structural analysis 

Notes

Acknowledgements

We thank the staff of the beamline BL44XU at SPring-8, Japan, for the help during data collection and Prof. Toshiki Yagi for providing the plasmid used in this study.

Funding information

This work was supported by a Grant-in-Aid for Scientific Research B (JP26291014) from the Japan Society for the Promotion of Science (JSPS) and JSPS Fellows Number JP17J07553.

Compliance with ethical standards

Conflict of interest

Akiyuki Toda declares that he has no conflict of interest. Hideaki Tanaka declares that he has no conflict of interest. Genji Kurisu declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute for Protein ResearchOsaka UniversityOsakaJapan
  2. 2.Department of Biological Sciences, Graduate School of ScienceOsaka UniversityOsakaJapan

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