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Charge matters

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References

  • Durant JA, Chen C, Laue TM, Moody TP, Allison SA (2002) Use of T4 lysozyme charge mutants to examine electrophoretic models. Biophys Chem 101–102:593–609

    Article  PubMed  Google Scholar 

  • Filoti DI, Shire SJ, Yadav S, Laue TM (2015) Comparative study of analytical techniques for determining protein charge. J Pharm Sci 104:2123–2131

    Article  CAS  PubMed  Google Scholar 

  • Gokarn YR, Fesinmeyer RM, Saluja A, Razinkov V, Chase SF, Laue TM, Brems DN (2011) Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions. Protein Sci 20:580–587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Her C, Filoti DI, McLean MA, Sligar SG, Ross JBA, Steele H, Laue TM (2016) The charge properties of phospholipid nanodiscs. Biophys J 111:989–998

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McConkey EH (1982) Molecular evolution, intracellular organization, and the quinary structure of proteins. Proc Natl Acad Sci U S A 79:3236–3240

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miao L, Qin H, Koehl P, Song J (2011) Selective and specific ion binding on proteins at physiologically-relevant concentrations. FEBS Lett 585:3126–3132

    Article  CAS  PubMed  Google Scholar 

  • Monteith WB, Cohen RD, Smith AE, Guzman-Cisneros E, Pielak GJ (2015) Quinary structure modulates protein stability in cells. Proc Natl Acad Sci U S A 112:1739–1742

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moody TP, Kingsbury JS, Durant JA, Wilson TJ, Chase SF, Laue TM (2005) Valence and anion binding of bovine ribonuclease A between pH 6 and 8. Anal Biochem 336:243–252

    Article  CAS  PubMed  Google Scholar 

  • Winzor DJ (2004) Determination of the net charge (valence) of a protein: a fundamental but elusive parameter. Anal Biochem 325:1–20

    Article  CAS  PubMed  Google Scholar 

  • Yadav S, Laue TM, Kalonia DS, Singh SN, Shire SJ (2012) The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions. Mol Pharm 9:791–802

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA

    Thomas Laue

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  1. Thomas Laue
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Correspondence to Thomas Laue.

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Thomas Laue declares that he has no conflicts of interest.

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This article does not contain any studies with human participants or animals performed by the author.

Additional information

This article is part of a Special Issue on “Analytical Quantitative Relations in Biochemistry” edited by Damien Hall and Stephen Harding.

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Laue, T. Charge matters. Biophys Rev 8, 287–289 (2016). https://doi.org/10.1007/s12551-016-0229-3

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  • DOI: https://doi.org/10.1007/s12551-016-0229-3

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