Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts

Estigoy, Colleen B.; Pontén, Fredrik; Odeberg, Jacob; Herbert, Benjamin; Guilhaus, Michael; Charleston, Michael; Ho, Joshua W. K.; Cameron, Darryl; dos Remedios, Cristobal G.

doi:10.1007/s12551-008-0007-y

Review
Published: 22 January 2009

Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts

Colleen B. Estigoy¹,
Fredrik Pontén²,
Jacob Odeberg³,
Benjamin Herbert⁴,
Michael Guilhaus⁵,
Michael Charleston⁶,
Joshua W. K. Ho^1,6,7,
Darryl Cameron¹ &
Cristobal G. dos Remedios¹

Biophysical Reviews volume 1, Article number: 43 (2009) Cite this article

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Abstract

The intercalated disc (ICD) occupies a central position in the transmission of force, electrical continuity and chemical communication between cardiomyocytes. Changes in its structure and composition are strongly implicated in heart failure. ICD functions include: maintenance of electrical continuity across the ICD; physical links between membranes and the cytoskeleton; intercellular adhesion; maintenance of ICD structure and function; and growth. About 200 known proteins are associated with ICDs, 40% of which change in disease. We systemically reviewed cardiac immunohistochemical data on the Human Protein Atlas (HPA) web site, ExPASy protein binding data and published papers on ICDs. We identified 43 proteins not previously reported, and confirmed 37 proteins that have previously been described. In addition, 102 proteins not present on the HPA web site but were described in ICDs in the literature. We group these into clusters that demonstrate functionally interactive groups of proteins demonstrating that ICDs play a key role in cardiomyocyte function.

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Notes

References to Eberth, Heidenhaim, Wegener and Marceau were cited in Saphir and Karsner (1924).

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Acknowledgement

This project was supported by a grant from the Australian Research Council FABLS Research Network.

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Affiliations

Bosch Institute, Department of Anatomy (F13), The University of Sydney, Sydney, 2006, Australia
Colleen B. Estigoy, Joshua W. K. Ho, Darryl Cameron & Cristobal G. dos Remedios
Human Proteome Research Group, Uppsala University, Dag Hammaskjold 20, 751-85, Uppsala, Sweden
Fredrik Pontén
Department of Biotechnology, Royal Institute of Technology, KTH AlbNov University Center, SE-10691, Stockholm, Sweden
Jacob Odeberg
Proteomics Technology Centre of Expertise, University of Technology, Broadway, 2006, Australia
Benjamin Herbert
Biomedical Mass Spectrometry Facility, University of New South Wales, Kensington, 2052, Australia
Michael Guilhaus
School of Information Technology, The University of Sydney, Sydney, 2006, Australia
Michael Charleston & Joshua W. K. Ho
NICTA, Australian Technology Park, Eveleigh, NSW, 2015, Australia
Joshua W. K. Ho

Authors

Colleen B. Estigoy
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Fredrik Pontén
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Jacob Odeberg
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Benjamin Herbert
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Michael Guilhaus
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Michael Charleston
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Joshua W. K. Ho
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Darryl Cameron
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Cristobal G. dos Remedios
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Correspondence to Cristobal G. dos Remedios.

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Estigoy, C.B., Pontén, F., Odeberg, J. et al. Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts. Biophys Rev 1, 43 (2009). https://doi.org/10.1007/s12551-008-0007-y

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Received: 14 December 2008
Accepted: 23 December 2008
Published: 22 January 2009
DOI: https://doi.org/10.1007/s12551-008-0007-y

Keywords

Cardiac intercalated disc
Functional protein groups
Immunohistochemistry
Changes in disease
Human heart

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Table 1

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