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Influence of implantation side on the integration of dental implants

A study on miniature pigs

  • original article
  • Published:
international journal of stomatology & occlusion medicine

Abstract

Background

The present work aimed to describe the incidental findings in a study of immediate loading of dental implants in pigs, i.e., the correlation between implant integration and the side of implantation.

Methods

In 11 adult miniature pigs, maxillary and mandibular premolars and the first molar were bilaterally extracted. A total of 100 dental implants with different surface characteristics were evaluated in the first stage. In the second stage, the two types of implants that yielded the best results were tested under loading conditions for 6 months. Statistical analysis included a one-way analysis of variance and a Holm–Sidak test.

Results

Histometric results showed significant differences in the bone-to-implant contact depending on the side of implantation. Higher rates of contact were found for implants placed in the left side; this was not related to the type of implant used.

Conclusions

Our results indicate that the side of implantation is important in dental implant research, at least in miniature pigs. We recommend that for each surgical procedure notes should be made about the side first operated on and whether the dentist was right- or left-handed. Moreover, special attention should be paid to objects placed in the animal pens so as to avoid the development of inappropriate behaviors in animals.

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References

  1. Gilmer CE. Goals and limitations of implant prosthodontics. J Am Dent Assoc. 1990;121:352–3.

    Article  CAS  PubMed  Google Scholar 

  2. Esposito M, Hirsch JM, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants (I). Success criteria and epidemiology. Eur J Oral Sci. 1998;106:527–51.

    Article  CAS  PubMed  Google Scholar 

  3. Esposito M, Hirsch JM, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants (II). Etiopathogenesis. Eur J Oral Sci 1998;106:721–64.

    Article  CAS  PubMed  Google Scholar 

  4. Uribe R, Peñarrocha M, Balaguer J, Fulgueiras N. Immediate loading in oral implants. Present situation. Med Oral Patol Oral. 2005;10(Suppl 2):E143–53.

    Google Scholar 

  5. Moy PK, Medina D, Shetty V, Aghaloo TL. Dental implant failure rates and associated risk factors. Int J Oral Max Impl. 2005;20:569–77.

    Google Scholar 

  6. Kronström M, Svenson B, Hellman M, Persson R. Early implant failures in patiens treated with Brånemark system titanium dental implants: a retrospective study. Int J Oral Max Impl. 2001;16:201–7.

    Google Scholar 

  7. Karoussis IK, Brägger U, Salvi GE, Bürgin W, Lang NP. Effect of implant design on survival and success rates of titanium oral implants: a 10-year prospective cohort study of ITI Dental Implant System. Clin Oral Implan Res. 2004;15:8–17.

    Article  Google Scholar 

  8. Duyck J, Naert I. Failure of oral implants: aetiology, symptoms and influencing factors. Clin Oral Invest. 1998;2:102–14.

    Article  CAS  Google Scholar 

  9. Alsaadi G, Quirynen M, Komárek A, Steenberghe D. Impact of local and systemic factors on the incidence of oral implants failures, up to abutment connection. J Clin Periodontol. 2007;34:610–7.

    Article  PubMed  Google Scholar 

  10. Steenberghe D, Quirynen M, Molly L, Jacobs R. Impact of systemic diseases and medication on osseintegration. Periodontol 2000. 2003;33:163–71.

    Article  PubMed  Google Scholar 

  11. Tolstunov L. Implants zones of the jaws: implant location and related success rate. J Oral Implant. 2007;33:211–20.

    Article  Google Scholar 

  12. Tonetti MS. Risk factors for osseointegration. Periodontol 2000. 1998;17:55–62.

    Article  CAS  PubMed  Google Scholar 

  13. Steenberghe D, Jacobs R, Desnyder M, Maffei G, Quirynen M. The relative impact of local and endogenous patient-related factors on implant failure up to the abutment stage. Clin Oral Implan Res. 2002;13:617–22.

    Article  Google Scholar 

  14. Chung DM, Oh T, Lee J, Misch CE, Wang H. Factors affecting late implant bone loss: a retrospective analysis. Int J Oral Max Impl. 2007;22:117–26.

    Google Scholar 

  15. Balshi TJ, Lee HY, Hernandez RE. The use of pterygomaxillary implants in the partially edentulous patient: a preliminary report. Int J Oral Max Impl. 1995;18:89–98.

    Google Scholar 

  16. Aparicio C, Padrós A, Gil FJ. In vivo evaluation of micro-rough and bioactive titanium dental implants using histometry and pull-out tests. J Mech Behav Biomed Mater. 2011;4:1672–82.

    Article  CAS  PubMed  Google Scholar 

  17. Gil FJ, Manzanares N, Badet A, Aparicio C, Ginebra MP. Biomimetic treatment on dental implants for short-term bone regeneration. Clin Oral Invest. 2014;18:59–66.

    Article  Google Scholar 

  18. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. Plos Biol. 2010;8(6):e1000412. doi:10.1371/journal.pbio.1000412.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic. J Biomed Mater Res. 1990;24:721–8.

    Article  CAS  PubMed  Google Scholar 

  20. Aparicio C, Gil FJ, Thams U, Munoz F, Padros A, Planell JA. Osseointegration of grit-blasted and bioactive titanium implants: histomorphometry in minipigs. Key Eng Mat. 2004;254–2:737–40.

    Article  Google Scholar 

  21. Aparicio C, Manero JM, Conde F, Pegueroles M, Planell JA, Vallet-Regí M, et al. Acceleration of apatite nucleation on microrough bioactive titanium for bone-replacing implants. J Biomed Mater Res. 2007;82A:521–9.

    Article  CAS  Google Scholar 

  22. Nkenke E, Lehner B, Weinzierl K, Thams U, Neugebauer J, Steveling H, et al. Bone contact, growth, and density around immediately loaded implants in the mandible of mini pigs. Clin Oral Implan Res. 2003;14:312–21.

    Article  Google Scholar 

  23. Donath K, Breuner G. A method for the study of undecalcified bones and teeth with attached soft tissues. J Oral Path. 1982;11:318–26.

    Article  CAS  PubMed  Google Scholar 

  24. Hale TM, Boretsky BB, Scheidt MJ, McQuade MJ, Strong SL. Evaluation of titanium dental implant osseointegration in edentulous areas of micro swine. J Oral Implantol. 1991;17:118–24.

    CAS  PubMed  Google Scholar 

  25. Canakci V, Tan U, Orbak R, Tezel A. Right- and left-handed dentists in periodontal therapy. Int J Neurosci. 2002;112:1–14.

    PubMed  Google Scholar 

  26. Orbak R, Tezel A, Canakci V, Tan U. Right- and left-handed dentist using right- and left-sided dental chairs in treatment of calculus. Int J Neurosci. 2002;112:15–30.

    Article  PubMed  Google Scholar 

  27. Park H, Jeong S, Kwon O. Factors affecting the clinical success of screw implants used as orthodontic anchorage. Am J Orthod Dentofac. 2006;130:18–25.

    Article  Google Scholar 

  28. Langenbach GEJ, Zhang F, Herring SW, van Eijden TMGJ, Hannam AG. Dymamic mechanics in the pig mandibular symphysis. J. Anat. 2006;209:69–78.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  29. Huang X, Zhang G, Herring SW. Effects of oral sensory afferents on mastication in the miniature pig. J Dent Res. 1993;72:980–6.

    Article  CAS  PubMed  Google Scholar 

  30. Herring SW, Rafferty KL, Liu ZJ, Marshall CD. Jaws muscles and the skull in mammals: the biomechanics of mastication. Comp Biochem Phys A. 2001;131:207–19.

    Article  CAS  Google Scholar 

  31. Zhang F, Langenbach GEJ, Hannam AG, Herring SW. Mass properties of the pig mandible. J Dent Res. 2001;80:327–35.

  32. Liu Z, Herring SW. Masticatory strains on osseous and ligamentous components of temporomandibular joint in miniature pigs. J Orofac Pain. 2000;14:265–78.

    CAS  PubMed  Google Scholar 

  33. Sun Z, Liu Z, Herring, SW. Movement of temporomandibular joint tissues during mastication and passive manipulation in miniature pigs. Arch Oral Biol. 2002;47:293–305.

    Article  PubMed  Google Scholar 

  34. Herring SW, Scapino RP. Physiology of feeding in miniature pigs. J Morphol. 2005;141:427–60.

    Article  Google Scholar 

  35. Liu ZJ, Gree JR, Moore CA, Herring SW. Time series analysis of jaw muscle contraction and tissue deformation during mastication in miniature pigs. J Oral Rehabil. 2004;31:7–17.

    Article  CAS  PubMed  Google Scholar 

  36. Herring SW. Mastication and maturity: a longitudinal study in pigs. J Dent Res. 1997;56:1377–82.

    Article  Google Scholar 

  37. Dailey JW, McGlone JJ. Oral/nasal/facial and other behaviors of sows kept individually outdoors on pasture, soil or indoors in gestation crates. Appl Anim Behav Sci. 1997;52:25–43.

    Article  Google Scholar 

  38. Lawrence AB, Terlouw EM. A review of behavioural factors involved in the development and continued performance of stereotypic behaviors in pigs. J Anim Sci. 1993;71:2815–25.

    CAS  PubMed  Google Scholar 

  39. Larsson E, Øgaard B, Lindsten R, Holmgren N, Brattberg M, Brattberg L. Craniofacial and dentofacial development in pigs fed soft and hard diets. Am J Orthod Dentofac. 2005;128:731–9.

    Article  Google Scholar 

  40. Olsen ML, Aaboe M, Hjørting-Hansen E, Hansen AK. Problems related to an intraoral approach for experimental surgery on minipigs. Clin Oral Implan Res. 2004;15:333–8.

    Article  Google Scholar 

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Authors and Affiliations

  1. Clinical Sciences Department, Veterinary Faculty, University of Santiago de Compostela, Campus Universitario, s/n., 27002, Lugo, Spain

    Mariano López-García DVM, PhD, Antonio González-Cantalapiedra DVM, PhD, Mónica López-Peña DVM, PhD & Fernando M. Muñoz Guzón

  2. Animal Medicine and Surgery, Veterinary Faculty, University Complutense de Madrid, Avenida Puerta de Hierro, s/n., 28040, Madrid, Spain

    Fidel San Román MD, DVM, PhD & Ulf Thams MD, PhD

Authors
  1. Mariano López-García DVM, PhD
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  2. Antonio González-Cantalapiedra DVM, PhD
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  3. Mónica López-Peña DVM, PhD
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  4. Fidel San Román MD, DVM, PhD
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  5. Ulf Thams MD, PhD
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  6. Fernando M. Muñoz Guzón
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Corresponding author

Correspondence to Fernando M. Muñoz Guzón.

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Conflict of interest

M. López-García, A. González-Cantalapiedra, M. López-Peña, F. San Román, U. Thams, and F.M. Muñoz Guzón state that there are no conflicts of interest.

All national guidelines on the care and use of laboratory animals have been followed and the necessary approval was obtained from the relevant authorities.

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López-García, M., González-Cantalapiedra, A., López-Peña, M. et al. Influence of implantation side on the integration of dental implants. J. Stomat. Occ. Med. 8, 41–46 (2015). https://doi.org/10.1007/s12548-015-0126-6

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  • DOI: https://doi.org/10.1007/s12548-015-0126-6

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