Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health leading to reduced life expectancy and/or increased health problems. As obesity is a multifaceted condition it has been implicated as a significant risk factor for numerous diseases, such as hypertension, cardiovascular disease and type 2 diabetes mellitus. Recently it has been found that obesity also appears to participate in the multifactorial etiology of periodontitis through increased production of reactive oxygen species and an increase in inflammatory cytokines. The association between impaired lipid metabolism and periodontitis still needs to be established. This review explains the mechanisms that link hyperlipidemia to periodontitis, which is probably related to the exacerbated proinflammatory changes in periodontal tissues.
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P, A., P, M., A, K. et al. Periodontal disease and obesity. J. Stomat. Occ. Med. 6, 1–5 (2013). https://doi.org/10.1007/s12548-012-0069-0
- Interleukin 6
- Tumor necrosis factor alpha